Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1229/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GATA2", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'C2H2 zinc finger domain binding', 'sequence-specific double-stranded DNA binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'transcription coactivator binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity', 'transcription coregulator binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "R-HSA-109582", "R-HSA-1266738", "R-HSA-212436", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8939236", "R-HSA-9616222", "R-HSA-983231" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P23769", "ensembl_id": "None", "entrez_id": "ENSG00000179348", "chromosome_number": "3", "lastmodified": "2024-02-29T15:02:20.830874" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3649" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GATA2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GATA2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GATA2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GATA2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GATA2/?format=api" } }, { "type": "Gene", "id": "KMT2D", "attributes": { "go_molecular_function": [ "['DNA binding', 'histone binding', 'protein binding', 'transcription cis-regulatory region binding', 'transcription coactivator activity', 'histone methyltransferase activity (H3-K4 specific)', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa00310", "kegg_path:hsa01100", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-162582", "R-HSA-195721", "R-HSA-201681", "R-HSA-201722", "R-HSA-212436", "R-HSA-3214841", "R-HSA-3247509", "R-HSA-3769402", "R-HSA-4839726", "R-HSA-5617472", "R-HSA-5619507", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8936459" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14686", "ensembl_id": "None", "entrez_id": "ENSG00000167548", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.900296" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2315" }, { "type": "SmallVariant", "id": "3388" }, { "type": "SmallVariant", "id": "3392" }, { "type": "SmallVariant", "id": "3394" }, { "type": "SmallVariant", "id": "3652" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2D/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2D/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "778" }, { "type": "GeneCombination", "id": "1135" }, { "type": "GeneCombination", "id": "1136" }, { "type": "GeneCombination", "id": "1137" }, { "type": "GeneCombination", "id": "1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2D/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KMT2D/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KMT2D/?format=api" } }, { "type": "Gene", "id": "NFKB1", "attributes": { "go_molecular_function": [ "['DNA-binding transcription repressor activity, RNA polymerase II-specific', 'chromatin binding', 'identical protein binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'actinin binding', 'transcription cis-regulatory region binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa01523", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04024", "kegg_path:hsa04062", "kegg_path:hsa04064", "kegg_path:hsa04066", "kegg_path:hsa04071", "kegg_path:hsa04151", "kegg_path:hsa04210", "kegg_path:hsa04211", "kegg_path:hsa04218", "kegg_path:hsa04380", "kegg_path:hsa04613", "kegg_path:hsa04620", "kegg_path:hsa04621", "kegg_path:hsa04622", "kegg_path:hsa04623", "kegg_path:hsa04625", "kegg_path:hsa04657", "kegg_path:hsa04658", "kegg_path:hsa04659", "kegg_path:hsa04660", "kegg_path:hsa04662", "kegg_path:hsa04668", "kegg_path:hsa04722", "kegg_path:hsa04917", "kegg_path:hsa04920", "kegg_path:hsa04926", "kegg_path:hsa04931", "kegg_path:hsa04932", "kegg_path:hsa04933", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05030", "kegg_path:hsa05120", "kegg_path:hsa05130", "kegg_path:hsa05131", "kegg_path:hsa05132", "kegg_path:hsa05133", "kegg_path:hsa05134", "kegg_path:hsa05135", "kegg_path:hsa05140", "kegg_path:hsa05142", "kegg_path:hsa05145", "kegg_path:hsa05146", "kegg_path:hsa05152", "kegg_path:hsa05160", "kegg_path:hsa05161", "kegg_path:hsa05162", "kegg_path:hsa05163", "kegg_path:hsa05164", "kegg_path:hsa05165", "kegg_path:hsa05166", "kegg_path:hsa05167", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05171", "kegg_path:hsa05200", "kegg_path:hsa05202", "kegg_path:hsa05203", "kegg_path:hsa05206", "kegg_path:hsa05212", "kegg_path:hsa05215", "kegg_path:hsa05220", "kegg_path:hsa05221", "kegg_path:hsa05222", "kegg_path:hsa05235", "kegg_path:hsa05321", "kegg_path:hsa05418", "R-HSA-1168372", "R-HSA-1169091", "R-HSA-1266738", "R-HSA-1280215", "R-HSA-1280218", "R-HSA-1606322", "R-HSA-162582", "R-HSA-1643685", "R-HSA-166016", "R-HSA-166058", "R-HSA-166166", "R-HSA-168138", "R-HSA-168142", "R-HSA-168164", "R-HSA-168176", "R-HSA-168179", "R-HSA-168181", "R-HSA-168188", "R-HSA-168249", "R-HSA-168256", "R-HSA-168643", "R-HSA-168898", "R-HSA-168928", "R-HSA-1810476", "R-HSA-181438", "R-HSA-1834949", "R-HSA-193639", "R-HSA-193692", "R-HSA-193704", "R-HSA-202403", "R-HSA-202424", "R-HSA-209560", "R-HSA-212436", "R-HSA-2262752", "R-HSA-2454202", "R-HSA-2559582", "R-HSA-2559583", "R-HSA-2871837", "R-HSA-3134963", "R-HSA-3214841", "R-HSA-3247509", "R-HSA-381340", "R-HSA-445989", "R-HSA-446652", "R-HSA-448424", "R-HSA-448706", "R-HSA-449147", "R-HSA-450294", "R-HSA-4839726", "R-HSA-5260271", "R-HSA-5602358", "R-HSA-5603029", "R-HSA-5607764", "R-HSA-5621481", "R-HSA-5621575", "R-HSA-5660668", "R-HSA-5663205", "R-HSA-5684264", "R-HSA-622312", "R-HSA-6798695", "R-HSA-73857", "R-HSA-73887", "R-HSA-74160", "R-HSA-844456", "R-HSA-8853884", "R-HSA-8953897", "R-HSA-9020702", "R-HSA-933542", "R-HSA-937061", "R-HSA-9609646", "R-HSA-9609690", "R-HSA-9658195", "R-HSA-9660826", "R-HSA-9664424", "R-HSA-975138", "R-HSA-975155", "R-HSA-975871", "R-HSA-983705" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P19838", "ensembl_id": "None", "entrez_id": "ENSG00000109320", "chromosome_number": "4", "lastmodified": "2024-02-29T15:02:20.838931" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3651" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NFKB1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NFKB1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NFKB1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NFKB1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NFKB1/?format=api" } }, { "type": "Gene", "id": "STAT5B", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'chromatin binding', 'identical protein binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'protein binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'glucocorticoid receptor binding', 'protein dimerization activity', 'DNA-binding transcription factor activity', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04012", "kegg_path:hsa04062", "kegg_path:hsa04217", "kegg_path:hsa04630", "kegg_path:hsa04658", "kegg_path:hsa04659", "kegg_path:hsa04917", "kegg_path:hsa04933", "kegg_path:hsa04935", "kegg_path:hsa05161", "kegg_path:hsa05162", "kegg_path:hsa05166", "kegg_path:hsa05200", "kegg_path:hsa05203", "kegg_path:hsa05220", "kegg_path:hsa05221", "kegg_path:hsa05223", "R-HSA-1170546", "R-HSA-1226099", "R-HSA-1266695", "R-HSA-1280215", "R-HSA-1433557", "R-HSA-162582", "R-HSA-1643685", "R-HSA-168256", "R-HSA-1839117", "R-HSA-1839124", "R-HSA-186763", "R-HSA-186797", "R-HSA-2586552", "R-HSA-449147", "R-HSA-451927", "R-HSA-512988", "R-HSA-5655302", "R-HSA-5663202", "R-HSA-8854691", "R-HSA-8983432", "R-HSA-8985947", "R-HSA-9006335", "R-HSA-9006934", "R-HSA-9020558", "R-HSA-9020958", "R-HSA-9027283", "R-HSA-9607240", "R-HSA-9645135", "R-HSA-9669938", "R-HSA-9670439", "R-HSA-9682385", "R-HSA-9702518", "R-HSA-9703465", "R-HSA-9703648", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P51692", "ensembl_id": "None", "entrez_id": "ENSG00000173757", "chromosome_number": "17", "lastmodified": "2024-02-29T15:02:20.847229" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3653" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STAT5B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STAT5B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/STAT5B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/STAT5B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/STAT5B/?format=api" } }, { "type": "Gene", "id": "TFRC", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'transferrin receptor activity', 'protein kinase binding', 'virus receptor activity', 'protein binding', 'RNA binding', 'double-stranded RNA binding', 'metalloexopeptidase activity', 'Hsp70 protein binding', 'chaperone binding', 'identical protein binding', 'protein-containing complex binding']" ], "pathway_id": [ "kegg_path:hsa04066", "kegg_path:hsa04144", "kegg_path:hsa04145", "kegg_path:hsa04216", "kegg_path:hsa04640", "R-HSA-199991", "R-HSA-199992", "R-HSA-382551", "R-HSA-432722", "R-HSA-5653656", "R-HSA-8856825", "R-HSA-8856828", "R-HSA-917937", "R-HSA-917977" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P02786", "ensembl_id": "None", "entrez_id": "ENSG00000072274", "chromosome_number": "3", "lastmodified": "2024-02-29T15:02:20.834813" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3650" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TFRC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TFRC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1229" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TFRC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TFRC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TFRC/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }