Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/509/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CELSR2", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "transmembrane signaling receptor activity", "calcium ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HCU4", "ensembl_id": "ENSG00000143126", "entrez_id": "1952", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.972153" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "1519" }, { "type": "SmallVariant", "id": "1536" }, { "type": "SmallVariant", "id": "1617" }, { "type": "SmallVariant", "id": "1623" }, { "type": "SmallVariant", "id": "1650" }, { "type": "SmallVariant", "id": "1665" }, { "type": "SmallVariant", "id": "1691" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "493" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "520" }, { "type": "GeneCombination", "id": "523" }, { "type": "GeneCombination", "id": "525" }, { "type": "GeneCombination", "id": "535" }, { "type": "GeneCombination", "id": "536" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/?format=api" } }, { "type": "Gene", "id": "GLDC", "attributes": { "go_molecular_function": [ "pyridoxal phosphate binding", "glycine binding", "pyridoxal binding", "glycine dehydrogenase (decarboxylating) activity", "lyase activity", "protein homodimerization activity", "electron transfer activity" ], "pathway_id": [ "kegg_path:hsa00630", "kegg_path:hsa01200", "kegg_path:hsa00260", "R-HSA-6783984", "R-HSA-1430728", "kegg_path:hsa01100", "R-HSA-389661", "R-HSA-71291" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P23378", "ensembl_id": "ENSG00000178445", "entrez_id": "2731", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.730189" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1551" }, { "type": "SmallVariant", "id": "1583" }, { "type": "SmallVariant", "id": "1624" }, { "type": "SmallVariant", "id": "1635" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLDC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLDC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "498" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "523" }, { "type": "GeneCombination", "id": "529" }, { "type": "GeneCombination", "id": "549" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLDC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLDC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLDC/?format=api" } }, { "type": "Gene", "id": "PDGFRA", "attributes": { "go_molecular_function": [ "protein kinase activity", "transmembrane receptor protein tyrosine kinase activity" ], "pathway_id": [ "R-HSA-1257604", "R-HSA-9006925", "R-HSA-9673767", "R-HSA-5673001", "R-HSA-9674415", "R-HSA-6811558", "kegg_path:hsa04014", "R-HSA-5683057", "R-HSA-9674396", "R-HSA-9674401", "kegg_path:hsa05214", "kegg_path:hsa04630", "kegg_path:hsa05163", "kegg_path:hsa05215", "R-HSA-9674428", "kegg_path:hsa04510", "kegg_path:hsa04810", "kegg_path:hsa05231", "R-HSA-2219528", "R-HSA-9674403", "kegg_path:hsa04144", "R-HSA-186763", "R-HSA-2219530", "kegg_path:hsa01521", "kegg_path:hsa04151", "kegg_path:hsa05206", "kegg_path:hsa05230", "R-HSA-1643685", "kegg_path:hsa05218", "kegg_path:hsa04015", "kegg_path:hsa04072", "R-HSA-199418", "R-HSA-9671555", "R-HSA-9006934", "R-HSA-9673770", "kegg_path:hsa04540", "kegg_path:hsa04010", "R-HSA-5684996", "kegg_path:hsa04020", "R-HSA-9674404", "R-HSA-162582", "R-HSA-186797", "R-HSA-5663202", "kegg_path:hsa05200" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P16234", "ensembl_id": "ENSG00000134853", "entrez_id": "5156", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.287648" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1498" }, { "type": "SmallVariant", "id": "1581" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PDGFRA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PDGFRA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "480" }, { "type": "GeneCombination", "id": "509" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PDGFRA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PDGFRA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PDGFRA/?format=api" } }, { "type": "Gene", "id": "SHROOM1", "attributes": { "go_molecular_function": [ "actin filament binding", "myosin II binding", "actin binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q2M3G4", "ensembl_id": "ENSG00000164403", "entrez_id": "134549", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.716488" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1567" }, { "type": "SmallVariant", "id": "1572" }, { "type": "SmallVariant", "id": "1582" }, { "type": "SmallVariant", "id": "1662" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "505" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHROOM1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHROOM1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }