Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/676/genes/?format=api
{ "data": [ { "type": "Gene", "id": "EGF", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "epidermal growth factor receptor binding", "transmembrane receptor protein tyrosine kinase activator activity", "growth factor activity", "guanyl-nucleotide exchange factor activity" ], "pathway_id": [ "R-HSA-1236382", "R-HSA-5663202", "kegg_path:hsa05200", "kegg_path:hsa04540", "R-HSA-9665348", "R-HSA-179812", "kegg_path:hsa04020", "R-HSA-162582", "R-HSA-1963642", "R-HSA-9013507", "R-HSA-2219530", "R-HSA-182971", "kegg_path:hsa04012", "R-HSA-9006934", "R-HSA-157118", "R-HSA-76002", "kegg_path:hsa05235", "R-HSA-109582", "R-HSA-8848021", "R-HSA-9664565", "kegg_path:hsa04015", "R-HSA-199418", "R-HSA-5653656", "R-HSA-1251932", "kegg_path:hsa05210", "R-HSA-5673001", "kegg_path:hsa05219", "R-HSA-1250196", "R-HSA-1227986", "R-HSA-1236394", "R-HSA-1257604", "R-HSA-9006925", "R-HSA-177929", "kegg_path:hsa05214", "R-HSA-1227990", "R-HSA-5638303", "R-HSA-5637812", "R-HSA-76005", "R-HSA-8863795", "kegg_path:hsa05165", "kegg_path:hsa05215", "R-HSA-6811558", "kegg_path:hsa04014", "R-HSA-5683057", "kegg_path:hsa04066", "R-HSA-1643713", "R-HSA-5637810", "kegg_path:hsa04810", "kegg_path:hsa05231", "R-HSA-2219528", "R-HSA-180292", "R-HSA-180336", "kegg_path:hsa04068", "R-HSA-1963640", "R-HSA-8939211", "kegg_path:hsa01521", "R-HSA-6785631", "R-HSA-8856825", "kegg_path:hsa04510", "R-HSA-5637815", "kegg_path:hsa05226", "R-HSA-9006927", "R-HSA-9634638", "kegg_path:hsa05218", "kegg_path:hsa04072", "R-HSA-114608", "R-HSA-8856828", "kegg_path:hsa05224", "R-HSA-9012852", "R-HSA-212718", "kegg_path:hsa04010", "kegg_path:hsa05213", "kegg_path:hsa05223", "R-HSA-5684996", "R-HSA-9009391", "kegg_path:hsa04630", "kegg_path:hsa05160", "R-HSA-5638302", "R-HSA-9665686", "R-HSA-199991", "R-HSA-8847993", "R-HSA-9006931", "kegg_path:hsa05212", "kegg_path:hsa04151", "R-HSA-1643685" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01133", "ensembl_id": "ENSG00000138798", "entrez_id": "1950", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.414266" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1850" }, { "type": "SmallVariant", "id": "1883" }, { "type": "SmallVariant", "id": "1909" }, { "type": "SmallVariant", "id": "1956" }, { "type": "SmallVariant", "id": "2161" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGF/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "614" }, { "type": "GeneCombination", "id": "627" }, { "type": "GeneCombination", "id": "641" }, { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "676" }, { "type": "GeneCombination", "id": "736" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EGF/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EGF/?format=api" } }, { "type": "Gene", "id": "NRP1", "attributes": { "go_molecular_function": [ "vascular endothelial growth factor-activated receptor activity", "protein binding", "metal ion binding" ], "pathway_id": [ "R-HSA-162582", "kegg_path:hsa05171", "R-HSA-399956", "kegg_path:hsa04360", "R-HSA-376176", "R-HSA-373755", "R-HSA-422475", "R-HSA-194138", "R-HSA-373760", "R-HSA-399954", "R-HSA-445144", "R-HSA-9675108", "R-HSA-447041", "kegg_path:hsa05166", "R-HSA-194306", "R-HSA-1266738", "R-HSA-9006934", "R-HSA-399955" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O14786", "ensembl_id": "ENSG00000099250", "entrez_id": "8829", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.297539" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1306" }, { "type": "SmallVariant", "id": "1420" }, { "type": "SmallVariant", "id": "1877" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NRP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NRP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "446" }, { "type": "GeneCombination", "id": "624" }, { "type": "GeneCombination", "id": "676" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NRP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NRP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NRP1/?format=api" } }, { "type": "Gene", "id": "RELN", "attributes": { "go_molecular_function": [ "['lipoprotein particle receptor binding', 'serine-type peptidase activity', 'very-low-density lipoprotein particle receptor binding', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa05017", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-422475", "R-HSA-8866376", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P78509", "ensembl_id": "None", "entrez_id": "ENSG00000189056", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.519444" }, "relationships": { "variant_set": { "meta": { "count": 24 }, "data": [ { "type": "SmallVariant", "id": "1852" }, { "type": "SmallVariant", "id": "1871" }, { "type": "SmallVariant", "id": "1891" }, { "type": "SmallVariant", "id": "1906" }, { "type": "SmallVariant", "id": "1930" }, { "type": "SmallVariant", "id": "1934" }, { "type": "SmallVariant", "id": "1936" }, { "type": "SmallVariant", "id": "1970" }, { "type": "SmallVariant", "id": "2332" }, { "type": "SmallVariant", "id": "2343" }, { "type": "SmallVariant", "id": "3063" }, { "type": "SmallVariant", "id": "3064" }, { "type": "SmallVariant", "id": "3069" }, { "type": "SmallVariant", "id": "3070" }, { "type": "SmallVariant", "id": "3072" }, { "type": "SmallVariant", "id": "3073" }, { "type": "SmallVariant", "id": "3075" }, { "type": "SmallVariant", "id": "3076" }, { "type": "SmallVariant", "id": "3079" }, { "type": "SmallVariant", "id": "3085" }, { "type": "SmallVariant", "id": "3088" }, { "type": "SmallVariant", "id": "3089" }, { "type": "SmallVariant", "id": "3092" }, { "type": "SmallVariant", "id": "3093" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RELN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 25 }, "data": [ { "type": "GeneCombination", "id": "644" }, { "type": "GeneCombination", "id": "615" }, { "type": "GeneCombination", "id": "621" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "639" }, { "type": "GeneCombination", "id": "642" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "652" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "654" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "664" }, { "type": "GeneCombination", "id": "668" }, { "type": "GeneCombination", "id": "670" }, { "type": "GeneCombination", "id": "676" }, { "type": "GeneCombination", "id": "785" }, { "type": "GeneCombination", "id": "791" }, { "type": "GeneCombination", "id": "1030" }, { "type": "GeneCombination", "id": "1031" }, { "type": "GeneCombination", "id": "1032" }, { "type": "GeneCombination", "id": "1033" }, { "type": "GeneCombination", "id": "1035" }, { "type": "GeneCombination", "id": "1036" }, { "type": "GeneCombination", "id": "1037" }, { "type": "GeneCombination", "id": "1028" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RELN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }