Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/612/genes/?format=api
{ "data": [ { "type": "Gene", "id": "NOTCH1", "attributes": { "go_molecular_function": [ "enzyme inhibitor activity", "calcium ion binding", "Notch binding", "chromatin DNA binding", "protein binding", "transcription coactivator activity", "transmembrane signaling receptor activity", "enzyme binding", "identical protein binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-1912420", "R-HSA-2660825", "R-HSA-5083630", "R-HSA-2660826", "R-HSA-1912422", "R-HSA-1643685", "kegg_path:hsa04919", "R-HSA-5668914", "kegg_path:hsa04658", "R-HSA-1266738", "R-HSA-2644607", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa01522", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2644605", "R-HSA-9013508", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "kegg_path:hsa05200", "R-HSA-2691230", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-1912399", "R-HSA-1912408", "R-HSA-162582", "R-HSA-1980143", "R-HSA-186712", "R-HSA-73857", "kegg_path:hsa05020", "R-HSA-2122948", "R-HSA-2691232", "kegg_path:hsa05224", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-8941856", "R-HSA-2644602", "R-HSA-3781865", "kegg_path:hsa05206", "R-HSA-210744", "R-HSA-2644606" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P46531", "ensembl_id": "ENSG00000148400", "entrez_id": "4851", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.838899" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1272" }, { "type": "SmallVariant", "id": "1287" }, { "type": "SmallVariant", "id": "1325" }, { "type": "SmallVariant", "id": "1844" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "612" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/?format=api" } }, { "type": "Gene", "id": "SLIT2", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'Roundabout binding', 'identical protein binding', 'heparin binding', 'calcium ion binding', 'protein binding', 'proteoglycan binding', 'GTPase inhibitor activity', 'laminin-1 binding']" ], "pathway_id": [ "kegg_path:hsa04360", "R-HSA-1266738", "R-HSA-373752", "R-HSA-376176", "R-HSA-422475", "R-HSA-428540", "R-HSA-428542", "R-HSA-428543", "R-HSA-428890", "R-HSA-8985586", "R-HSA-9010553", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O94813", "ensembl_id": "None", "entrez_id": "ENSG00000145147", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.360257" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1845" }, { "type": "SmallVariant", "id": "1924" }, { "type": "SmallVariant", "id": "1966" }, { "type": "SmallVariant", "id": "3699" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLIT2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLIT2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "612" }, { "type": "GeneCombination", "id": "649" }, { "type": "GeneCombination", "id": "673" }, { "type": "GeneCombination", "id": "1251" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SLIT2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SLIT2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SLIT2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }