Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1224/genes/?format=api
{ "data": [ { "type": "Gene", "id": "IL21R", "attributes": { "go_molecular_function": [ "['protein binding', 'cytokine receptor activity', 'interleukin-21 receptor activity', 'transmembrane signaling receptor activity']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04630", "kegg_path:hsa04659", "kegg_path:hsa05321", "R-HSA-1280215", "R-HSA-168256", "R-HSA-449147", "R-HSA-451927", "R-HSA-9020958" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HBE5", "ensembl_id": "None", "entrez_id": "ENSG00000103522", "chromosome_number": "16", "lastmodified": "2024-02-29T15:02:20.800443" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3638" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL21R/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL21R/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1224" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IL21R/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IL21R/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IL21R/?format=api" } }, { "type": "Gene", "id": "TAP1", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'ATPase-coupled transmembrane transporter activity', 'MHC class Ib protein binding', 'ABC-type peptide transporter activity', 'ABC-type peptide antigen transporter activity', 'protein binding', 'ADP binding', 'MHC class I protein binding', 'peptide transmembrane transporter activity', 'peptide antigen binding', 'TAP2 binding', 'metal ion binding', 'TAP1 binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa02010", "kegg_path:hsa04145", "kegg_path:hsa04612", "kegg_path:hsa05163", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05340", "kegg_path:hsa02010", "kegg_path:hsa04145", "kegg_path:hsa04612", "kegg_path:hsa05163", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05340", "R-HSA-1236974", "R-HSA-1236975", "R-HSA-1280218", "R-HSA-168256", "R-HSA-983169", "R-HSA-983170", "kegg_path:hsa02010", "kegg_path:hsa04145", "kegg_path:hsa04612", "kegg_path:hsa05163", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05340", "kegg_path:hsa02010", "kegg_path:hsa04145", "kegg_path:hsa04612", "kegg_path:hsa05163", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05340", "kegg_path:hsa02010", "kegg_path:hsa04145", "kegg_path:hsa04612", "kegg_path:hsa05163", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05340", "R-HSA-1236974", "R-HSA-1236975", "R-HSA-1280218", "R-HSA-168256", "R-HSA-983169", "R-HSA-983170", "kegg_path:hsa02010", "kegg_path:hsa04145", "kegg_path:hsa04612", "kegg_path:hsa05163", "kegg_path:hsa05168", "kegg_path:hsa05169", "kegg_path:hsa05170", "kegg_path:hsa05340" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A0A140T9T7", "ensembl_id": "None", "entrez_id": "ENSG00000168394", "chromosome_number": "6", "lastmodified": "2024-02-29T15:02:20.796173" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3637" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TAP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TAP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1224" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TAP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TAP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TAP1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }