Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1225/genes/?format=api
{ "data": [ { "type": "Gene", "id": "NCF2", "attributes": { "go_molecular_function": [ "['small GTPase binding', 'electron transfer activity', 'protein C-terminus binding', 'protein binding', 'superoxide-generating NADPH oxidase activator activity', 'superoxide-generating NAD(P)H oxidase activity']" ], "pathway_id": [ "kegg_path:hsa04145", "kegg_path:hsa04380", "kegg_path:hsa04613", "kegg_path:hsa04670", "kegg_path:hsa05020", "kegg_path:hsa05140", "kegg_path:hsa05418", "kegg_path:hsa04145", "kegg_path:hsa04380", "kegg_path:hsa04613", "kegg_path:hsa04670", "kegg_path:hsa05020", "kegg_path:hsa05140", "kegg_path:hsa05418", "R-HSA-1222556", "R-HSA-1236973", "R-HSA-1236975", "R-HSA-1280218", "R-HSA-162582", "R-HSA-168249", "R-HSA-168256", "R-HSA-194138", "R-HSA-194315", "R-HSA-195258", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-4420097", "R-HSA-5668599", "R-HSA-8953897", "R-HSA-9006934", "R-HSA-983169" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P19878", "ensembl_id": "None", "entrez_id": "ENSG00000116701", "chromosome_number": "1", "lastmodified": "2024-02-29T15:02:20.804578" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3639" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCF2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCF2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1225" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCF2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCF2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NCF2/?format=api" } }, { "type": "Gene", "id": "TCIRG1", "attributes": { "go_molecular_function": [ "['ATPase binding', 'transporter activity', 'protein binding', 'proton transmembrane transporter activity']" ], "pathway_id": [ "kegg_path:hsa00190", "kegg_path:hsa01100", "kegg_path:hsa04142", "kegg_path:hsa04145", "kegg_path:hsa04721", "kegg_path:hsa04966", "kegg_path:hsa05110", "kegg_path:hsa05120", "kegg_path:hsa05152", "kegg_path:hsa05165", "kegg_path:hsa05323", "kegg_path:hsa00190", "kegg_path:hsa01100", "kegg_path:hsa04142", "kegg_path:hsa04145", "kegg_path:hsa04721", "kegg_path:hsa04966", "kegg_path:hsa05110", "kegg_path:hsa05120", "kegg_path:hsa05152", "kegg_path:hsa05165", "kegg_path:hsa05323", "R-HSA-1222556", "R-HSA-162582", "R-HSA-168249", "R-HSA-168256", "R-HSA-2262752", "R-HSA-382551", "R-HSA-6798695", "R-HSA-74752", "R-HSA-77387", "R-HSA-8953897", "R-HSA-9006934", "R-HSA-917937", "R-HSA-917977", "R-HSA-9639288", "R-HSA-983712" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13488", "ensembl_id": "None", "entrez_id": "ENSG00000110719", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.321685" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1091" }, { "type": "SmallVariant", "id": "3640" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TCIRG1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TCIRG1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "358" }, { "type": "GeneCombination", "id": "1225" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TCIRG1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TCIRG1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TCIRG1/?format=api" } }, { "type": "Gene", "id": "TIRAP", "attributes": { "go_molecular_function": [ "['protein kinase C binding', 'protein-macromolecule adaptor activity', 'Toll-like receptor 4 binding', 'Toll-like receptor 2 binding', 'protein binding', 'phosphatidylinositol-4,5-bisphosphate binding', 'NAD+ nucleosidase activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04064", "kegg_path:hsa04620", "kegg_path:hsa05130", "kegg_path:hsa05132", "kegg_path:hsa05133", "kegg_path:hsa05152", "kegg_path:hsa05161", "kegg_path:hsa05235", "kegg_path:hsa04064", "kegg_path:hsa04620", "kegg_path:hsa05130", "kegg_path:hsa05132", "kegg_path:hsa05133", "kegg_path:hsa05152", "kegg_path:hsa05161", "kegg_path:hsa05235", "R-HSA-1236974", "R-HSA-1236975", "R-HSA-1280218", "R-HSA-1643685", "R-HSA-166016", "R-HSA-166058", "R-HSA-168179", "R-HSA-168188", "R-HSA-168249", "R-HSA-168256", "R-HSA-168898", "R-HSA-181438", "R-HSA-5260271", "R-HSA-5602358", "R-HSA-5602498", "R-HSA-5603041", "R-HSA-983169" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P58753", "ensembl_id": "None", "entrez_id": "ENSG00000150455", "chromosome_number": "11", "lastmodified": "2024-02-29T15:02:20.813367" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3641" }, { "type": "SmallVariant", "id": "3643" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TIRAP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TIRAP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1225" }, { "type": "GeneCombination", "id": "1226" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TIRAP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TIRAP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TIRAP/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }