Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/134/genes/?format=api
{ "data": [ { "type": "Gene", "id": "KCNQ1", "attributes": { "go_molecular_function": [ "delayed rectifier potassium channel activity", "voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization", "protein kinase A catalytic subunit binding", "protein binding", "scaffold protein binding", "voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization", "transmembrane transporter binding", "voltage-gated potassium channel activity", "voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization", "protein phosphatase 1 binding", "protein kinase A regulatory subunit binding", "outward rectifier potassium channel activity", "calmodulin binding", "phosphatidylinositol-4,5-bisphosphate binding" ], "pathway_id": [ "kegg_path:hsa04725", "R-HSA-112316", "R-HSA-397014", "kegg_path:hsa04971", "R-HSA-1296071", "R-HSA-1296072", "R-HSA-5576891", "kegg_path:hsa04972", "R-HSA-5576890", "kegg_path:hsa04261", "R-HSA-5576893", "kegg_path:hsa04974", "kegg_path:hsa05110" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P51787", "ensembl_id": "ENSG00000053918", "entrez_id": "3784", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.693442" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "197" }, { "type": "SmallVariant", "id": "394" }, { "type": "SmallVariant", "id": "792" }, { "type": "SmallVariant", "id": "794" }, { "type": "SmallVariant", "id": "946" }, { "type": "SmallVariant", "id": "1144" }, { "type": "SmallVariant", "id": "2585" }, { "type": "SmallVariant", "id": "2587" }, { "type": "SmallVariant", "id": "2589" }, { "type": "SmallVariant", "id": "2590" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KCNQ1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KCNQ1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "71" }, { "type": "GeneCombination", "id": "134" }, { "type": "GeneCombination", "id": "366" }, { "type": "GeneCombination", "id": "861" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KCNQ1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KCNQ1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KCNQ1/?format=api" } }, { "type": "Gene", "id": "SCN5A", "attributes": { "go_molecular_function": [ "protein kinase binding", "protein domain specific binding", "protein binding", "enzyme binding", "nitric-oxide synthase binding", "voltage-gated sodium channel activity involved in bundle of His cell action potential", "voltage-gated ion channel activity", "voltage-gated sodium channel activity involved in cardiac muscle cell action potential", "transmembrane transporter binding", "voltage-gated sodium channel activity", "ubiquitin protein ligase binding", "scaffold protein binding", "ankyrin binding", "voltage-gated sodium channel activity involved in AV node cell action potential", "fibroblast growth factor binding", "voltage-gated sodium channel activity involved in SA node cell action potential", "calmodulin binding", "voltage-gated sodium channel activity involved in Purkinje myocyte action potential" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-5576891", "R-HSA-397014", "R-HSA-445095", "R-HSA-373760", "R-HSA-9675108", "R-HSA-422475", "R-HSA-5576892", "kegg_path:hsa04261", "kegg_path:hsa04261" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "H9KVD2", "ensembl_id": "ENSG00000183873", "entrez_id": "6331", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.270806" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "947" }, { "type": "SmallVariant", "id": "357" }, { "type": "SmallVariant", "id": "393" }, { "type": "SmallVariant", "id": "797" }, { "type": "SmallVariant", "id": "799" }, { "type": "SmallVariant", "id": "1395" }, { "type": "SmallVariant", "id": "2141" }, { "type": "SmallVariant", "id": "2599" }, { "type": "SmallVariant", "id": "2601" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCN5A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCN5A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "123" }, { "type": "GeneCombination", "id": "134" }, { "type": "GeneCombination", "id": "249" }, { "type": "GeneCombination", "id": "250" }, { "type": "GeneCombination", "id": "439" }, { "type": "GeneCombination", "id": "862" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SCN5A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SCN5A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SCN5A/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }