Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/502/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALX1", "attributes": { "go_molecular_function": [ "protein binding", "DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15699", "ensembl_id": "ENSG00000180318", "entrez_id": "8092", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.526993" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1561" }, { "type": "SmallVariant", "id": "1576" }, { "type": "SmallVariant", "id": "1610" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "507" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/?format=api" } }, { "type": "Gene", "id": "MTRR", "attributes": { "go_molecular_function": [ "protein binding", "[methionine synthase] reductase activity", "FMN binding", "oxidoreductase activity, acting on metal ions, NAD or NADP as acceptor", "flavin adenine dinucleotide binding", "oxidoreductase activity" ], "pathway_id": [ "R-HSA-196854", "R-HSA-196741", "R-HSA-3296469", "R-HSA-1643685", "R-HSA-196849", "R-HSA-5668914", "R-HSA-3359469", "R-HSA-1430728", "R-HSA-156580", "R-HSA-1614635", "R-HSA-71291", "R-HSA-211859", "R-HSA-3296482", "R-HSA-3359467", "R-HSA-156581" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9UBK8", "ensembl_id": "ENSG00000124275", "entrez_id": "4552", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.434297" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1562" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTRR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTRR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "502" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTRR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTRR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTRR/?format=api" } }, { "type": "Gene", "id": "ZIC3", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "protein binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity" ], "pathway_id": [ "R-HSA-2892247", "R-HSA-452723", "R-HSA-1266738", "kegg_path:hsa04550" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60481", "ensembl_id": "ENSG00000156925", "entrez_id": "7547", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.879577" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZIC3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "110" }, { "type": "GeneCombination", "id": "112" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "548" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZIC3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }