Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/811/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GJB2", "attributes": { "go_molecular_function": [ "['gap junction channel activity involved in cell communication by electrical coupling', 'calcium ion binding', 'gap junction channel activity', 'protein binding', 'identical protein binding']" ], "pathway_id": [ "R-HSA-157858", "R-HSA-190704", "R-HSA-190827", "R-HSA-190828", "R-HSA-190861", "R-HSA-190872", "R-HSA-199991", "R-HSA-5653656" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P29033", "ensembl_id": "None", "entrez_id": "ENSG00000165474", "chromosome_number": "13", "lastmodified": "2021-10-18T11:00:44.377664" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "24" }, { "type": "SmallVariant", "id": "120" }, { "type": "SmallVariant", "id": "282" }, { "type": "SmallVariant", "id": "283" }, { "type": "SmallVariant", "id": "376" }, { "type": "SmallVariant", "id": "378" }, { "type": "SmallVariant", "id": "490" }, { "type": "SmallVariant", "id": "874" }, { "type": "SmallVariant", "id": "2388" }, { "type": "SmallVariant", "id": "2754" }, { "type": "SmallVariant", "id": "2755" }, { "type": "SmallVariant", "id": "2759" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GJB2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GJB2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "9" }, { "type": "GeneCombination", "id": "101" }, { "type": "GeneCombination", "id": "102" }, { "type": "GeneCombination", "id": "164" }, { "type": "GeneCombination", "id": "814" }, { "type": "GeneCombination", "id": "813" }, { "type": "GeneCombination", "id": "811" }, { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "920" }, { "type": "GeneCombination", "id": "921" }, { "type": "GeneCombination", "id": "922" }, { "type": "GeneCombination", "id": "923" }, { "type": "GeneCombination", "id": "924" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GJB2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GJB2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GJB2/?format=api" } }, { "type": "Gene", "id": "KCNQ4", "attributes": { "go_molecular_function": [ "delayed rectifier potassium channel activity", "protein binding", "voltage-gated potassium channel activity", "potassium channel activity", "calmodulin binding" ], "pathway_id": [ "kegg_path:hsa04725", "R-HSA-1296071", "R-HSA-1296072", "R-HSA-112316" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P56696", "ensembl_id": "ENSG00000117013", "entrez_id": "9132", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:58.561165" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2392" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KCNQ4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KCNQ4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "811" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/KCNQ4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/KCNQ4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/KCNQ4/?format=api" } }, { "type": "Gene", "id": "MPDZ", "attributes": { "go_molecular_function": [ "['protein C-terminus binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04530" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O75970", "ensembl_id": "None", "entrez_id": "ENSG00000107186", "chromosome_number": "9", "lastmodified": "2022-08-04T14:14:58.260603" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2391" }, { "type": "SmallVariant", "id": "3300" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MPDZ/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MPDZ/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "810" }, { "type": "GeneCombination", "id": "811" }, { "type": "GeneCombination", "id": "812" }, { "type": "GeneCombination", "id": "813" }, { "type": "GeneCombination", "id": "814" }, { "type": "GeneCombination", "id": "1110" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MPDZ/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MPDZ/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MPDZ/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }