Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1252/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADAMTS16", "attributes": { "go_molecular_function": [ "['metalloendopeptidase activity', 'metal ion binding']" ], "pathway_id": [ "R-HSA-1474228", "R-HSA-1474244", "R-HSA-1643685", "R-HSA-3781865", "R-HSA-3906995", "R-HSA-392499", "R-HSA-5083635", "R-HSA-5173105", "R-HSA-5173214", "R-HSA-5668914", "R-HSA-597592" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8TE57", "ensembl_id": "None", "entrez_id": "ENSG00000145536", "chromosome_number": "5", "lastmodified": "2022-08-04T14:14:58.302365" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2255" }, { "type": "SmallVariant", "id": "3701" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS16/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADAMTS16/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS16/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADAMTS16/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS16/?format=api" } }, { "type": "Gene", "id": "FGFR3", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein binding', 'fibroblast growth factor-activated receptor activity', 'fibroblast growth factor binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230", "R-HSA-1226099", "R-HSA-1643685", "R-HSA-1839130", "R-HSA-2033514", "R-HSA-2033515", "R-HSA-5655332", "R-HSA-5663202", "R-HSA-8853334", "R-HSA-8853338", "kegg_path:hsa01521", "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04020", "kegg_path:hsa04144", "kegg_path:hsa04151", "kegg_path:hsa04550", "kegg_path:hsa04810", "kegg_path:hsa05200", "kegg_path:hsa05206", "kegg_path:hsa05219", "kegg_path:hsa05230" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P22607", "ensembl_id": "None", "entrez_id": "ENSG00000068078", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.500473" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1152" }, { "type": "SmallVariant", "id": "3209" }, { "type": "SmallVariant", "id": "3276" }, { "type": "SmallVariant", "id": "3333" }, { "type": "SmallVariant", "id": "3700" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "369" }, { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1124" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FGFR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FGFR3/?format=api" } }, { "type": "Gene", "id": "INSR", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'insulin-like growth factor II binding', 'phosphatidylinositol 3-kinase binding', 'insulin binding', 'insulin-like growth factor receptor binding', 'PTB domain binding', 'protein serine/threonine/tyrosine kinase activity', 'transmembrane receptor protein tyrosine kinase activity', 'protein binding', 'protein domain specific binding', 'insulin receptor substrate binding', 'insulin-like growth factor I binding', 'protein-containing complex binding', 'GTP binding', 'amyloid-beta binding', 'insulin-activated receptor activity', 'cargo receptor activity', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04022", "kegg_path:hsa04066", "kegg_path:hsa04068", "kegg_path:hsa04072", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04152", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04520", "kegg_path:hsa04910", "kegg_path:hsa04913", "kegg_path:hsa04923", "kegg_path:hsa04930", "kegg_path:hsa04931", "kegg_path:hsa04932", "kegg_path:hsa04960", "kegg_path:hsa05010", "R-HSA-1257604", "R-HSA-162582", "R-HSA-199418", "R-HSA-6811558", "R-HSA-74713", "R-HSA-74749", "R-HSA-74751", "R-HSA-74752", "R-HSA-77387", "R-HSA-9006925", "R-HSA-9006934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P06213", "ensembl_id": "None", "entrez_id": "ENSG00000171105", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.378754" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1568" }, { "type": "SmallVariant", "id": "3702" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INSR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INSR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "504" }, { "type": "GeneCombination", "id": "1252" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/INSR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/INSR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/INSR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }