Gene Combination Instance – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genecombinations/863/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": {
        "type": "GeneCombination",
        "id": "863",
        "attributes": {
            "gene_relationship": [
                "Monogenic experiments only",
                "Involved in the same disease",
                "Affecting the same tissue",
                "Same pathway",
                "Relevant pathways for phenotype"
            ],
            "protein_interactions": [
                "(FN1, ITGAV)"
            ],
            "common_pathways": [
                "Non-integrin membrane-ECM interactions",
                "Integrin cell surface interactions",
                "Regulation of actin cytoskeleton",
                "Extracellular matrix organization",
                "Immune System",
                "Elastic fibre formation",
                "Signal Transduction",
                "Molecules associated with elastic fibres",
                "ECM-receptor interaction",
                "Syndecan interactions",
                "Pathways in cancer",
                "Small cell lung cancer",
                "Focal adhesion",
                "Signaling by Receptor Tyrosine Kinases",
                "PI3K-Akt signaling pathway",
                "Human papillomavirus infection",
                "Proteoglycans in cancer",
                "ECM proteoglycans",
                "Cell surface interactions at the vascular wall",
                "Hemostasis"
            ],
            "genecomb_metascore": 2,
            "lastmodified": "2024-03-01T15:19:57.782883"
        },
        "relationships": {
            "combination_set": {
                "meta": {
                    "count": 1
                },
                "data": [
                    {
                        "type": "Combination",
                        "id": "OLI1230"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/863/relationships/combination_set?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/863/combinations/?format=api"
                }
            },
            "genes": {
                "meta": {
                    "count": 2
                },
                "data": [
                    {
                        "type": "Gene",
                        "id": "FN1"
                    },
                    {
                        "type": "Gene",
                        "id": "ITGAV"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/863/relationships/genes?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/863/genes/?format=api"
                }
            }
        },
        "links": {
            "self": "https://olida.ibsquare.be/api/genecombinations/863/?format=api"
        }
    }
}