Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/295/genes/?format=api
{ "data": [ { "type": "Gene", "id": "DCTN1", "attributes": { "go_molecular_function": [ "['protein kinase binding', 'tubulin binding', 'microtubule binding', 'protein binding', 'microtubule plus-end binding', 'tau protein binding']" ], "pathway_id": [ "kegg_path:hsa04962", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05022", "kegg_path:hsa05132", "R-HSA-1280218", "R-HSA-168256", "R-HSA-199977", "R-HSA-199991", "R-HSA-2132295", "R-HSA-2262752", "R-HSA-3371497", "R-HSA-381038", "R-HSA-381070", "R-HSA-381119", "R-HSA-392499", "R-HSA-446203", "R-HSA-5653656", "R-HSA-597592", "R-HSA-6807878", "R-HSA-6811436", "R-HSA-6811442", "R-HSA-8856688", "R-HSA-8953897", "R-HSA-948021" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14203", "ensembl_id": "None", "entrez_id": "ENSG00000204843", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.560161" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "529" }, { "type": "SmallVariant", "id": "537" }, { "type": "SmallVariant", "id": "543" }, { "type": "SmallVariant", "id": "548" }, { "type": "SmallVariant", "id": "933" }, { "type": "SmallVariant", "id": "1724" }, { "type": "SmallVariant", "id": "2060" }, { "type": "SmallVariant", "id": "2084" }, { "type": "SmallVariant", "id": "3433" }, { "type": "SmallVariant", "id": "3445" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCTN1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCTN1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "175" }, { "type": "GeneCombination", "id": "181" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "567" }, { "type": "GeneCombination", "id": "710" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCTN1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCTN1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DCTN1/?format=api" } }, { "type": "Gene", "id": "OPTN", "attributes": { "go_molecular_function": [ "['small GTPase binding', 'protein-macromolecule adaptor activity', 'protein C-terminus binding', 'protein binding', 'polyubiquitin modification-dependent protein binding', 'K63-linked polyubiquitin modification-dependent protein binding', 'metal ion binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04137", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1640170", "R-HSA-199991", "R-HSA-2565942", "R-HSA-453274", "R-HSA-5653656", "R-HSA-69275", "R-HSA-69278", "R-HSA-8854214", "R-HSA-9007101" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96CV9", "ensembl_id": "None", "entrez_id": "ENSG00000123240", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.918424" }, "relationships": { "variant_set": { "meta": { "count": 14 }, "data": [ { "type": "SmallVariant", "id": "791" }, { "type": "SmallVariant", "id": "922" }, { "type": "SmallVariant", "id": "930" }, { "type": "SmallVariant", "id": "1171" }, { "type": "SmallVariant", "id": "1224" }, { "type": "SmallVariant", "id": "1375" }, { "type": "SmallVariant", "id": "1376" }, { "type": "SmallVariant", "id": "1387" }, { "type": "SmallVariant", "id": "1393" }, { "type": "SmallVariant", "id": "1436" }, { "type": "SmallVariant", "id": "1707" }, { "type": "SmallVariant", "id": "1710" }, { "type": "SmallVariant", "id": "2201" }, { "type": "SmallVariant", "id": "3601" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OPTN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OPTN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "248" }, { "type": "GeneCombination", "id": "290" }, { "type": "GeneCombination", "id": "294" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "300" }, { "type": "GeneCombination", "id": "377" }, { "type": "GeneCombination", "id": "390" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "455" }, { "type": "GeneCombination", "id": "560" }, { "type": "GeneCombination", "id": "1212" }, { "type": "GeneCombination", "id": "750" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OPTN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OPTN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/OPTN/?format=api" } }, { "type": "Gene", "id": "TARDBP", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', \"mRNA 3'-UTR binding\", 'pre-mRNA intronic binding', 'double-stranded DNA binding', 'protein binding', 'RNA binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa05014", "kegg_path:hsa05022" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13148", "ensembl_id": "None", "entrez_id": "ENSG00000120948", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.778821" }, "relationships": { "variant_set": { "meta": { "count": 12 }, "data": [ { "type": "SmallVariant", "id": "540" }, { "type": "SmallVariant", "id": "871" }, { "type": "SmallVariant", "id": "932" }, { "type": "SmallVariant", "id": "1430" }, { "type": "SmallVariant", "id": "1695" }, { "type": "SmallVariant", "id": "1704" }, { "type": "SmallVariant", "id": "2750" }, { "type": "SmallVariant", "id": "3060" }, { "type": "SmallVariant", "id": "3416" }, { "type": "SmallVariant", "id": "3440" }, { "type": "SmallVariant", "id": "3444" }, { "type": "SmallVariant", "id": "3607" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "183" }, { "type": "GeneCombination", "id": "271" }, { "type": "GeneCombination", "id": "295" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "916" }, { "type": "GeneCombination", "id": "917" }, { "type": "GeneCombination", "id": "919" }, { "type": "GeneCombination", "id": "553" }, { "type": "GeneCombination", "id": "1027" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1146" }, { "type": "GeneCombination", "id": "1155" }, { "type": "GeneCombination", "id": "1157" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TARDBP/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TARDBP/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }