Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/730/genes/?format=api
{ "data": [ { "type": "Gene", "id": "OBSCN", "attributes": { "go_molecular_function": [ "phosphatidylinositol-3-phosphate binding", "protein binding", "phosphatidylinositol-3,4-bisphosphate binding", "protein serine/threonine kinase activity", "phosphatidylinositol-3,4,5-trisphosphate binding", "cell adhesion molecule binding", "protein serine/threonine/tyrosine kinase activity", "phosphatidylinositol-5-phosphate binding", "ankyrin binding", "metal ion binding", "guanyl-nucleotide exchange factor activity", "phosphatidylinositol-4-phosphate binding", "ATP binding", "structural constituent of muscle", "calmodulin binding", "titin binding", "protein serine kinase activity", "phosphatidylinositol-4,5-bisphosphate binding" ], "pathway_id": [ "R-HSA-416482", "R-HSA-194840", "R-HSA-194315", "R-HSA-73887", "R-HSA-388396", "R-HSA-193648", "R-HSA-162582", "R-HSA-372790", "R-HSA-193704", "R-HSA-204998" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "A6NGQ3", "ensembl_id": "ENSG00000154358", "entrez_id": "84033", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.673864" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1402" }, { "type": "SmallVariant", "id": "2116" }, { "type": "SmallVariant", "id": "2117" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OBSCN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OBSCN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "441" }, { "type": "GeneCombination", "id": "729" }, { "type": "GeneCombination", "id": "730" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/OBSCN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/OBSCN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/OBSCN/?format=api" } }, { "type": "Gene", "id": "PLEC", "attributes": { "go_molecular_function": [ "protein binding", "structural molecule activity", "ankyrin binding", "structural constituent of cytoskeleton", "dystroglycan binding", "RNA binding", "actin binding", "protein self-association", "cadherin binding", "structural constituent of muscle" ], "pathway_id": [ "R-HSA-446728", "R-HSA-1500931", "R-HSA-109581", "R-HSA-5357801", "R-HSA-2022090", "R-HSA-1474290", "R-HSA-264870", "R-HSA-2022090", "R-HSA-1474290", "R-HSA-264870", "R-HSA-109581", "R-HSA-5357801", "R-HSA-111465", "R-HSA-1500931", "R-HSA-1474244", "R-HSA-446107", "R-HSA-446728", "R-HSA-75153", "R-HSA-446107", "R-HSA-75153", "R-HSA-1474244", "R-HSA-111465" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15149", "ensembl_id": "ENSG00000178209", "entrez_id": "5339", "chromosome_number": "8", "lastmodified": "2022-08-04T14:14:59.833601" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2118" }, { "type": "SmallVariant", "id": "2119" }, { "type": "SmallVariant", "id": "2311" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLEC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLEC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "730" }, { "type": "GeneCombination", "id": "731" }, { "type": "GeneCombination", "id": "776" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PLEC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PLEC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PLEC/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }