Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/219/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ARHGEF10", "attributes": { "go_molecular_function": [ "kinesin binding", "guanyl-nucleotide exchange factor activity", "protein binding" ], "pathway_id": [ "R-HSA-204998", "R-HSA-193704", "R-HSA-162582", "R-HSA-372790", "R-HSA-193648", "R-HSA-388396", "R-HSA-73887", "R-HSA-194315", "R-HSA-194840", "R-HSA-416482" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O15013", "ensembl_id": "ENSG00000104728", "entrez_id": "9639", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.524565" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "666" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGEF10/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGEF10/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "219" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGEF10/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGEF10/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGEF10/?format=api" } }, { "type": "Gene", "id": "FAM126A", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9BYI3", "ensembl_id": "ENSG00000122591", "entrez_id": "84668", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.356251" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "667" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAM126A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAM126A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "219" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAM126A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAM126A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FAM126A/?format=api" } }, { "type": "Gene", "id": "GRWD1", "attributes": { "go_molecular_function": [ "protein binding", "histone binding", "DNA replication origin binding", "RNA binding", "chromatin binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9BQ67", "ensembl_id": "ENSG00000105447", "entrez_id": "83743", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.956282" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "668" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRWD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRWD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "219" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRWD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRWD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GRWD1/?format=api" } }, { "type": "Gene", "id": "HEXB", "attributes": { "go_molecular_function": [ "beta-N-acetylhexosaminidase activity", "N-acetyl-beta-D-galactosaminidase activity", "hydrolase activity, hydrolyzing O-glycosyl compounds", "hydrolase activity", "hydrolase activity, acting on glycosyl bonds", "identical protein binding" ], "pathway_id": [ "R-HSA-428157", "kegg_path:hsa00513", "R-HSA-1660662", "R-HSA-2022857", "R-HSA-71387", "R-HSA-1430728", "kegg_path:hsa00520", "kegg_path:hsa04142", "R-HSA-1630316", "kegg_path:hsa00531", "R-HSA-168256", "kegg_path:hsa00603", "R-HSA-5668914", "kegg_path:hsa00604", "R-HSA-2142845", "R-HSA-2160916", "R-HSA-168249", "kegg_path:hsa00511", "R-HSA-1643685", "R-HSA-3781865", "kegg_path:hsa00511", "R-HSA-556833", "R-HSA-6798695", "kegg_path:hsa00604", "kegg_path:hsa00603", "R-HSA-2024101", "kegg_path:hsa00531", "kegg_path:hsa04142", "kegg_path:hsa00520", "R-HSA-1638074", "R-HSA-1793185", "R-HSA-3656248", "kegg_path:hsa00513", "kegg_path:hsa01100", "kegg_path:hsa01100", "R-HSA-3560782" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P07686", "ensembl_id": "ENSG00000049860", "entrez_id": "3074", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.460255" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "669" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HEXB/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HEXB/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "219" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HEXB/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HEXB/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HEXB/?format=api" } }, { "type": "Gene", "id": "ITPR1", "attributes": { "go_molecular_function": [ "phosphatidylinositol binding", "inositol 1,4,5 trisphosphate binding", "protein binding", "calcium ion binding", "calcium-release channel activity", "inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-983705", "R-HSA-195721", "kegg_path:hsa04723", "R-HSA-372790", "R-HSA-9006925", "R-HSA-3858494", "R-HSA-418457", "R-HSA-2871809", "R-HSA-5578775", "kegg_path:hsa04921", "R-HSA-163685", "kegg_path:hsa04912", "kegg_path:hsa04210", "kegg_path:hsa04611", "kegg_path:hsa04726", "kegg_path:hsa04020", "R-HSA-162582", "kegg_path:hsa04925", "kegg_path:hsa05022", "R-HSA-9664323", "R-HSA-983695", "kegg_path:hsa05131", "kegg_path:hsa04724", "R-HSA-2029485", "R-HSA-9658195", "kegg_path:hsa04218", "kegg_path:hsa05205", "R-HSA-139853", "R-HSA-418594", "R-HSA-5663205", "kegg_path:hsa04371", "kegg_path:hsa04725", "kegg_path:hsa04728", "R-HSA-392154", "R-HSA-418346", "kegg_path:hsa04922", "kegg_path:hsa04928", "kegg_path:hsa05163", "R-HSA-5576891", "R-HSA-9664433", "R-HSA-416476", "R-HSA-112040", "R-HSA-112043", "kegg_path:hsa04972", "R-HSA-381676", "kegg_path:hsa04927", "R-HSA-1489509", "R-HSA-418360", "R-HSA-422356", "R-HSA-1280218", "R-HSA-168249", "R-HSA-5621481", "kegg_path:hsa04935", "kegg_path:hsa04270", "kegg_path:hsa04713", "kegg_path:hsa04970", "R-HSA-1643685", "R-HSA-109582", "kegg_path:hsa04114", "kegg_path:hsa04625", "kegg_path:hsa04730", "kegg_path:hsa04720", "kegg_path:hsa05167", "R-HSA-5607763", "R-HSA-9006934", "R-HSA-76002", "kegg_path:hsa04750", "kegg_path:hsa05016", "R-HSA-2454202", "kegg_path:hsa05017", "R-HSA-9662851", "kegg_path:hsa04924", "kegg_path:hsa04022", "R-HSA-194138", "R-HSA-4086398", "R-HSA-114508", "kegg_path:hsa04934", "R-HSA-111885", "R-HSA-168256", "kegg_path:hsa04140", "kegg_path:hsa04929", "R-HSA-388396", "R-HSA-5607764", "R-HSA-397014", "kegg_path:hsa04918", "kegg_path:hsa04971", "R-HSA-2029480", "kegg_path:hsa05170", "R-HSA-1430728", "kegg_path:hsa05012", "kegg_path:hsa04070", "kegg_path:hsa05010", "kegg_path:hsa05020", "kegg_path:hsa04540", "kegg_path:hsa04915", "R-HSA-4420097", "R-HSA-5218921" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q14643", "ensembl_id": "ENSG00000150995", "entrez_id": "3708", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.563079" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "670" }, { "type": "SmallVariant", "id": "679" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ITPR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ITPR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ITPR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ITPR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ITPR1/?format=api" } }, { "type": "Gene", "id": "MARS1", "attributes": { "go_molecular_function": [ "methionine-tRNA ligase activity" ], "pathway_id": [ "R-HSA-72766", "R-HSA-2408522", "R-HSA-392499", "kegg_path:hsa00450", "R-HSA-379716", "R-HSA-71291", "kegg_path:hsa00970", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-379724" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P56192", "ensembl_id": "ENSG00000166986", "entrez_id": "4141", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.718353" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "671" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MARS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MARS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "219" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MARS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MARS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MARS1/?format=api" } }, { "type": "Gene", "id": "POLG2", "attributes": { "go_molecular_function": [ "DNA polymerase processivity factor activity", "double-stranded DNA binding" ], "pathway_id": [ "R-HSA-1592230", "R-HSA-2151201", "R-HSA-1852241", "R-HSA-1592230", "R-HSA-1852241", "R-HSA-2151201" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9UHN1", "ensembl_id": "ENSG00000256525", "entrez_id": "11232", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.763497" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "672" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLG2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLG2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "219" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POLG2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POLG2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POLG2/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 8 } }