Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/405/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CYP1A1", "attributes": { "go_molecular_function": [ "oxygen binding", "lyase activity", "hydroperoxy icosatetraenoate dehydratase activity", "aromatase activity", "metal ion binding", "monooxygenase activity", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa04913", "kegg_path:hsa04913", "R-HSA-8978868", "R-HSA-2142670", "R-HSA-1430728", "R-HSA-2142816", "R-HSA-9018677", "kegg_path:hsa05204", "kegg_path:hsa05204", "R-HSA-1989781", "R-HSA-211859", "kegg_path:hsa00380", "kegg_path:hsa00380", "R-HSA-211897", "R-HSA-211945", "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-556833", "R-HSA-9018681", "kegg_path:hsa00830", "kegg_path:hsa00830", "R-HSA-211981", "R-HSA-2142753", "R-HSA-9018678", "kegg_path:hsa00980", "kegg_path:hsa00980", "R-HSA-400206" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P04798", "ensembl_id": "ENSG00000140465", "entrez_id": "1543", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.968652" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "738" }, { "type": "SmallVariant", "id": "743" }, { "type": "SmallVariant", "id": "1269" }, { "type": "SmallVariant", "id": "1296" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP1A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP1A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/?format=api" } }, { "type": "Gene", "id": "EVC", "attributes": { "go_molecular_function": [], "pathway_id": [ "kegg_path:hsa04340", "R-HSA-162582", "R-HSA-5358351", "R-HSA-5632684", "R-HSA-5635838" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000072840", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.537890" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "764" }, { "type": "SmallVariant", "id": "765" }, { "type": "SmallVariant", "id": "1270" }, { "type": "SmallVariant", "id": "1277" }, { "type": "SmallVariant", "id": "1311" }, { "type": "SmallVariant", "id": "2635" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EVC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "878" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EVC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EVC/?format=api" } }, { "type": "Gene", "id": "GRID1", "attributes": { "go_molecular_function": [ "signaling receptor activity", "ligand-gated ion channel activity", "ionotropic glutamate receptor activity", "identical protein binding" ], "pathway_id": [ "kegg_path:hsa04080" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9ULK0", "ensembl_id": "ENSG00000182771", "entrez_id": "2894", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.342384" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1271" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRID1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRID1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "405" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GRID1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GRID1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GRID1/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "NOTCH1", "attributes": { "go_molecular_function": [ "enzyme inhibitor activity", "calcium ion binding", "Notch binding", "chromatin DNA binding", "protein binding", "transcription coactivator activity", "transmembrane signaling receptor activity", "enzyme binding", "identical protein binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-1912420", "R-HSA-2660825", "R-HSA-5083630", "R-HSA-2660826", "R-HSA-1912422", "R-HSA-1643685", "kegg_path:hsa04919", "R-HSA-5668914", "kegg_path:hsa04658", "R-HSA-1266738", "R-HSA-2644607", "kegg_path:hsa05165", "R-HSA-3906995", "kegg_path:hsa01522", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2644605", "R-HSA-9013508", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "kegg_path:hsa05200", "R-HSA-2691230", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-1912399", "R-HSA-1912408", "R-HSA-162582", "R-HSA-1980143", "R-HSA-186712", "R-HSA-73857", "kegg_path:hsa05020", "R-HSA-2122948", "R-HSA-2691232", "kegg_path:hsa05224", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-8941856", "R-HSA-2644602", "R-HSA-3781865", "kegg_path:hsa05206", "R-HSA-210744", "R-HSA-2644606" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P46531", "ensembl_id": "ENSG00000148400", "entrez_id": "4851", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.838899" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1272" }, { "type": "SmallVariant", "id": "1287" }, { "type": "SmallVariant", "id": "1325" }, { "type": "SmallVariant", "id": "1844" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "612" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOTCH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOTCH1/?format=api" } }, { "type": "Gene", "id": "RET", "attributes": { "go_molecular_function": [ "protein binding", "transmembrane receptor protein tyrosine kinase activity" ], "pathway_id": [ "kegg_path:hsa05230", "R-HSA-5673001", "R-HSA-162582", "R-HSA-8853659", "kegg_path:hsa04020", "kegg_path:hsa05223", "R-HSA-5684996", "kegg_path:hsa05216", "kegg_path:hsa05223", "kegg_path:hsa05216", "R-HSA-1266738", "kegg_path:hsa04020", "R-HSA-422475", "R-HSA-5683057", "R-HSA-9675108", "kegg_path:hsa05230", "kegg_path:hsa05200", "kegg_path:hsa05200" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P07949", "ensembl_id": "ENSG00000165731", "entrez_id": "5979", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.700530" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "42" }, { "type": "SmallVariant", "id": "75" }, { "type": "SmallVariant", "id": "360" }, { "type": "SmallVariant", "id": "718" }, { "type": "SmallVariant", "id": "734" }, { "type": "SmallVariant", "id": "1273" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RET/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RET/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "17" }, { "type": "GeneCombination", "id": "30" }, { "type": "GeneCombination", "id": "124" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "405" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RET/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RET/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RET/?format=api" } }, { "type": "Gene", "id": "RIPK4", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "kinase activity", "protein serine/threonine kinase activity", "ATP binding", "nucleotide binding", "protein kinase activity", "protein serine kinase activity" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P57078", "ensembl_id": "ENSG00000183421", "entrez_id": "54101", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.266300" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1274" }, { "type": "SmallVariant", "id": "1275" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RIPK4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RIPK4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "405" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RIPK4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RIPK4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RIPK4/?format=api" } }, { "type": "Gene", "id": "ZBTB16", "attributes": { "go_molecular_function": [ "protein C-terminus binding", "protein binding", "DNA-binding transcription repressor activity, RNA polymerase II-specific", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "protein domain specific binding", "DNA-binding transcription factor activity", "double-stranded DNA binding" ], "pathway_id": [ "R-HSA-8951664", "R-HSA-983169", "R-HSA-168256", "kegg_path:hsa05221", "R-HSA-983168", "kegg_path:hsa05221", "kegg_path:hsa05200", "kegg_path:hsa05202", "R-HSA-1280218", "R-HSA-392499", "kegg_path:hsa05202", "kegg_path:hsa05200", "R-HSA-597592" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q05516", "ensembl_id": "ENSG00000109906", "entrez_id": "7704", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.523737" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1276" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZBTB16/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZBTB16/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "405" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZBTB16/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZBTB16/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZBTB16/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 8 } }