Combination List
This API endpoint handles listing (/combinations) and retrieval (/combinations/{combination_pk}/) of oligogenic combinations from the database
GET /api/genecombinations/115/combinations/?format=api
{ "data": [ { "type": "Combination", "id": "OLI159", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Monogenic+Modifier", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.081913" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "2227" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI159/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI159/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "322" }, { "type": "SmallVariant", "id": "323" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI159/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI159/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI159/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI159/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI159/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI159/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "115" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI159/?format=api" } }, { "type": "Combination", "id": "OLI160", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Monogenic+Modifier", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.097784" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "2227" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI160/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI160/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "323" }, { "type": "SmallVariant", "id": "324" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI160/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI160/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI160/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI160/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI160/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI160/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "115" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI160/?format=api" } }, { "type": "Combination", "id": "OLI161", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 1, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 0, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.113620" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "2227" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI161/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI161/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "323" }, { "type": "SmallVariant", "id": "325" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI161/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI161/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI161/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI161/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI161/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI161/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "115" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI161/?format=api" } }, { "type": "Combination", "id": "OLI162", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 1, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 2, "final_manual": 0, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.129262" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "2227" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI162/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI162/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "326" }, { "type": "SmallVariant", "id": "327" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI162/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI162/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI162/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI162/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI162/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI162/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "115" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI162/?format=api" } }, { "type": "Combination", "id": "OLI163", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 1, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 2, "final_manual": 0, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.144847" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "2227" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI163/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI163/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "327" }, { "type": "SmallVariant", "id": "328" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI163/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI163/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI163/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI163/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI163/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI163/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "115" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI163/?format=api" } }, { "type": "Combination", "id": "OLI164", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 1, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 2, "final_manual": 0, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.160503" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "2227" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI164/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI164/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "323" }, { "type": "SmallVariant", "id": "329" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI164/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI164/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI164/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI164/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI164/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI164/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "115" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI164/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }