Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1007/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MCTP2", "attributes": { "go_molecular_function": [ "['calcium ion binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q6DN12", "ensembl_id": "None", "entrez_id": "ENSG00000140563", "chromosome_number": "15", "lastmodified": "2023-05-16T12:02:33.195962" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3016" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MCTP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MCTP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1007" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MCTP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MCTP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MCTP2/?format=api" } }, { "type": "Gene", "id": "ROCK1", "attributes": { "go_molecular_function": [ "['protein kinase activity', 'aspartic-type endopeptidase inhibitor activity', 'tau-protein kinase activity', 'small GTPase binding', 'protein serine/threonine kinase activity', 'Rho-dependent protein serine/threonine kinase activity', 'ATP binding', 'protein serine kinase activity', 'protein binding', 'metal ion binding', 'tau protein binding', 'protein serine/threonine/tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa04022", "kegg_path:hsa04024", "kegg_path:hsa04062", "kegg_path:hsa04071", "kegg_path:hsa04270", "kegg_path:hsa04350", "kegg_path:hsa04360", "kegg_path:hsa04510", "kegg_path:hsa04530", "kegg_path:hsa04611", "kegg_path:hsa04670", "kegg_path:hsa04810", "kegg_path:hsa04921", "kegg_path:hsa05130", "kegg_path:hsa05131", "kegg_path:hsa05135", "kegg_path:hsa05163", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "R-HSA-109581", "R-HSA-111465", "R-HSA-1266738", "R-HSA-162582", "R-HSA-1643685", "R-HSA-168249", "R-HSA-168256", "R-HSA-194138", "R-HSA-194315", "R-HSA-194840", "R-HSA-195258", "R-HSA-2682334", "R-HSA-372790", "R-HSA-373755", "R-HSA-388396", "R-HSA-3928662", "R-HSA-3928663", "R-HSA-400685", "R-HSA-416482", "R-HSA-416572", "R-HSA-422475", "R-HSA-4420097", "R-HSA-5357801", "R-HSA-5627117", "R-HSA-5663205", "R-HSA-6798695", "R-HSA-75153", "R-HSA-9006934", "R-HSA-9013422", "R-HSA-9675108", "R-HSA-9679191", "R-HSA-9679506", "R-HSA-9706574" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13464", "ensembl_id": "None", "entrez_id": "ENSG00000067900", "chromosome_number": "18", "lastmodified": "2023-05-16T12:02:33.192513" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3015" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROCK1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROCK1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1007" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ROCK1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ROCK1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ROCK1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }