Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1077/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'proline-rich region binding', 'SH2 domain binding', 'growth hormone receptor activity', 'protein kinase binding', 'cytokine binding', 'protein phosphatase binding', 'protein binding', 'growth factor binding', 'protein homodimerization activity', 'cytokine receptor activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04151", "kegg_path:hsa04630", "kegg_path:hsa04935", "R-HSA-1170546", "R-HSA-1280215", "R-HSA-168256", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10912", "ensembl_id": "None", "entrez_id": "ENSG00000112964", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.556257" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1957" }, { "type": "SmallVariant", "id": "1967" }, { "type": "SmallVariant", "id": "3219" }, { "type": "SmallVariant", "id": "3222" }, { "type": "SmallVariant", "id": "3232" }, { "type": "SmallVariant", "id": "3249" }, { "type": "SmallVariant", "id": "3269" }, { "type": "SmallVariant", "id": "3279" }, { "type": "SmallVariant", "id": "3330" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "674" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1099" }, { "type": "GeneCombination", "id": "1103" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/?format=api" } }, { "type": "Gene", "id": "SRD5A2", "attributes": { "go_molecular_function": [ "['amide binding', 'testosterone dehydrogenase [NAD(P)] activity', 'protein binding', 'oxidoreductase activity', 'cholestenone 5-alpha-reductase activity', '3-oxo-5-alpha-steroid 4-dehydrogenase activity', 'sterol 5-alpha reductase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa05215", "R-HSA-1430728", "R-HSA-193048", "R-HSA-196071", "R-HSA-556833", "R-HSA-8957322" ], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000277893", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.477987" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "583" }, { "type": "SmallVariant", "id": "2172" }, { "type": "SmallVariant", "id": "2179" }, { "type": "SmallVariant", "id": "3182" }, { "type": "SmallVariant", "id": "3206" }, { "type": "SmallVariant", "id": "3221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRD5A2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRD5A2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "201" }, { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "739" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1071" }, { "type": "GeneCombination", "id": "1084" }, { "type": "GeneCombination", "id": "1090" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRD5A2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRD5A2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SRD5A2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2024 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }