Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/507/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALX1", "attributes": { "go_molecular_function": [ "protein binding", "DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15699", "ensembl_id": "ENSG00000180318", "entrez_id": "8092", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.526993" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1561" }, { "type": "SmallVariant", "id": "1576" }, { "type": "SmallVariant", "id": "1610" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "507" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "533" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALX1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALX1/?format=api" } }, { "type": "Gene", "id": "CTH", "attributes": { "go_molecular_function": [ "pyridoxal phosphate binding", "protein binding", "L-cystine L-cysteine-lyase (deaminating)", "catalytic activity", "cystathionine gamma-lyase activity", "carbon-sulfur lyase activity", "calmodulin binding" ], "pathway_id": [ "R-HSA-1614635", "kegg_path:hsa01230", "R-HSA-1430728", "R-HSA-2408508", "kegg_path:hsa01100", "R-HSA-1614558", "R-HSA-71291", "kegg_path:hsa00450", "kegg_path:hsa00270", "R-HSA-2408522", "kegg_path:hsa00260", "R-HSA-1614603" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P32929", "ensembl_id": "ENSG00000116761", "entrez_id": "1491", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.431147" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1575" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CTH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CTH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "507" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CTH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CTH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CTH/?format=api" } }, { "type": "Gene", "id": "FZD6", "attributes": { "go_molecular_function": [ "Wnt-protein binding", "G protein-coupled receptor activity", "protein binding", "Wnt-activated receptor activity" ], "pathway_id": [ "R-HSA-162582", "R-HSA-373080", "R-HSA-5663202", "kegg_path:hsa05205", "kegg_path:hsa05022", "kegg_path:hsa05200", "kegg_path:hsa05022", "kegg_path:hsa05205", "R-HSA-5340588", "kegg_path:hsa05200", "kegg_path:hsa04934", "kegg_path:hsa04310", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04390", "kegg_path:hsa05010", "kegg_path:hsa05226", "R-HSA-201681", "kegg_path:hsa04150", "kegg_path:hsa05217", "R-HSA-1643685", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05217", "kegg_path:hsa04150", "kegg_path:hsa05225", "kegg_path:hsa05224", "kegg_path:hsa04390", "R-HSA-4086400", "R-HSA-4791275", "kegg_path:hsa05226", "kegg_path:hsa05010", "kegg_path:hsa04934", "R-HSA-500792", "R-HSA-372790", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04310", "R-HSA-195721", "kegg_path:hsa04916", "kegg_path:hsa04916", "R-HSA-4641263", "R-HSA-3858494", "R-HSA-4086398" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60353", "ensembl_id": "ENSG00000164930", "entrez_id": "8323", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.861195" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1522" }, { "type": "SmallVariant", "id": "1560" }, { "type": "SmallVariant", "id": "1578" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "501" }, { "type": "GeneCombination", "id": "507" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FZD6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FZD6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FZD6/?format=api" } }, { "type": "Gene", "id": "MTHFD1", "attributes": { "go_molecular_function": [ "formate-tetrahydrofolate ligase activity", "protein binding", "methylenetetrahydrofolate dehydrogenase (NADP+) activity", "methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity", "methenyltetrahydrofolate cyclohydrolase activity" ], "pathway_id": [ "kegg_path:hsa00670", "kegg_path:hsa01240", "kegg_path:hsa01100", "R-HSA-1430728", "kegg_path:hsa00670", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-196757", "R-HSA-196854", "R-HSA-196849" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P11586", "ensembl_id": "ENSG00000100714", "entrez_id": "4522", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.454249" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1520" }, { "type": "SmallVariant", "id": "1577" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "507" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTHFD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTHFD1/?format=api" } }, { "type": "Gene", "id": "SALL4", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-6807070", "R-HSA-452723", "R-HSA-1266738", "R-HSA-1257604", "R-HSA-162582", "R-HSA-2892247", "R-HSA-8943724", "R-HSA-9006925" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9UJQ4", "ensembl_id": "ENSG00000101115", "entrez_id": "57167", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.839866" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1540" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "494" }, { "type": "GeneCombination", "id": "507" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SALL4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SALL4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SALL4/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }