Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/236/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CYP1A1", "attributes": { "go_molecular_function": [ "oxygen binding", "lyase activity", "hydroperoxy icosatetraenoate dehydratase activity", "aromatase activity", "metal ion binding", "monooxygenase activity", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa04913", "kegg_path:hsa04913", "R-HSA-8978868", "R-HSA-2142670", "R-HSA-1430728", "R-HSA-2142816", "R-HSA-9018677", "kegg_path:hsa05204", "kegg_path:hsa05204", "R-HSA-1989781", "R-HSA-211859", "kegg_path:hsa00380", "kegg_path:hsa00380", "R-HSA-211897", "R-HSA-211945", "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-556833", "R-HSA-9018681", "kegg_path:hsa00830", "kegg_path:hsa00830", "R-HSA-211981", "R-HSA-2142753", "R-HSA-9018678", "kegg_path:hsa00980", "kegg_path:hsa00980", "R-HSA-400206" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P04798", "ensembl_id": "ENSG00000140465", "entrez_id": "1543", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.968652" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "738" }, { "type": "SmallVariant", "id": "743" }, { "type": "SmallVariant", "id": "1269" }, { "type": "SmallVariant", "id": "1296" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP1A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP1A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/?format=api" } }, { "type": "Gene", "id": "FRAS1", "attributes": { "go_molecular_function": [ "extracellular matrix structural constituent", "metal ion binding" ], "pathway_id": [ "kegg_path:hsa04512" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q86XX4", "ensembl_id": "ENSG00000138759", "entrez_id": "80144", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.949161" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "709" }, { "type": "SmallVariant", "id": "740" }, { "type": "SmallVariant", "id": "750" }, { "type": "SmallVariant", "id": "751" }, { "type": "SmallVariant", "id": "756" }, { "type": "SmallVariant", "id": "766" }, { "type": "SmallVariant", "id": "1299" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FRAS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "227" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FRAS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/?format=api" } }, { "type": "Gene", "id": "GLI3", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'beta-catenin binding', 'metal ion binding', 'histone acetyltransferase binding', 'sequence-specific double-stranded DNA binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'mediator complex binding', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'histone deacetylase binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04340", "kegg_path:hsa05200", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-212436", "R-HSA-5358351", "R-HSA-5610785", "R-HSA-5610787", "R-HSA-5632684", "R-HSA-5635851", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878166", "R-HSA-8940973", "R-HSA-8941326" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10071", "ensembl_id": "None", "entrez_id": "ENSG00000106571", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.894304" }, "relationships": { "variant_set": { "meta": { "count": 16 }, "data": [ { "type": "SmallVariant", "id": "726" }, { "type": "SmallVariant", "id": "731" }, { "type": "SmallVariant", "id": "732" }, { "type": "SmallVariant", "id": "741" }, { "type": "SmallVariant", "id": "900" }, { "type": "SmallVariant", "id": "916" }, { "type": "SmallVariant", "id": "1300" }, { "type": "SmallVariant", "id": "2769" }, { "type": "SmallVariant", "id": "2834" }, { "type": "SmallVariant", "id": "2847" }, { "type": "SmallVariant", "id": "2889" }, { "type": "SmallVariant", "id": "2963" }, { "type": "SmallVariant", "id": "3180" }, { "type": "SmallVariant", "id": "3214" }, { "type": "SmallVariant", "id": "3230" }, { "type": "SmallVariant", "id": "3324" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "287" }, { "type": "GeneCombination", "id": "279" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "926" }, { "type": "GeneCombination", "id": "942" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "986" }, { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1081" }, { "type": "GeneCombination", "id": "1115" }, { "type": "GeneCombination", "id": "1118" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1074" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GLI3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GLI3/?format=api" } }, { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "MYO7A", "attributes": { "go_molecular_function": [ "['calmodulin binding', 'spectrin binding', 'protein binding', 'protein domain specific binding', 'microfilament motor activity', 'actin filament binding', 'ATP binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q13402", "ensembl_id": "None", "entrez_id": "ENSG00000137474", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.573189" }, "relationships": { "variant_set": { "meta": { "count": 28 }, "data": [ { "type": "SmallVariant", "id": "509" }, { "type": "SmallVariant", "id": "206" }, { "type": "SmallVariant", "id": "207" }, { "type": "SmallVariant", "id": "211" }, { "type": "SmallVariant", "id": "213" }, { "type": "SmallVariant", "id": "218" }, { "type": "SmallVariant", "id": "221" }, { "type": "SmallVariant", "id": "503" }, { "type": "SmallVariant", "id": "507" }, { "type": "SmallVariant", "id": "720" }, { "type": "SmallVariant", "id": "727" }, { "type": "SmallVariant", "id": "728" }, { "type": "SmallVariant", "id": "737" }, { "type": "SmallVariant", "id": "747" }, { "type": "SmallVariant", "id": "748" }, { "type": "SmallVariant", "id": "759" }, { "type": "SmallVariant", "id": "1323" }, { "type": "SmallVariant", "id": "1324" }, { "type": "SmallVariant", "id": "1975" }, { "type": "SmallVariant", "id": "2233" }, { "type": "SmallVariant", "id": "2235" }, { "type": "SmallVariant", "id": "2237" }, { "type": "SmallVariant", "id": "2239" }, { "type": "SmallVariant", "id": "2241" }, { "type": "SmallVariant", "id": "2243" }, { "type": "SmallVariant", "id": "2245" }, { "type": "SmallVariant", "id": "3704" }, { "type": "SmallVariant", "id": "3712" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 16 }, "data": [ { "type": "GeneCombination", "id": "75" }, { "type": "GeneCombination", "id": "76" }, { "type": "GeneCombination", "id": "77" }, { "type": "GeneCombination", "id": "78" }, { "type": "GeneCombination", "id": "80" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "168" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "758" }, { "type": "GeneCombination", "id": "757" }, { "type": "GeneCombination", "id": "1256" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO7A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYO7A/?format=api" } }, { "type": "Gene", "id": "WNT9A", "attributes": { "go_molecular_function": [ "protein binding", "signaling receptor binding", "cytokine activity", "frizzled binding", "receptor ligand activity" ], "pathway_id": [ "kegg_path:hsa05224", "kegg_path:hsa05205", "R-HSA-3772470", "kegg_path:hsa05010", "kegg_path:hsa04916", "kegg_path:hsa05022", "R-HSA-201681", "kegg_path:hsa05200", "kegg_path:hsa05226", "kegg_path:hsa05217", "kegg_path:hsa05225", "kegg_path:hsa04310", "kegg_path:hsa04390", "kegg_path:hsa05205", "kegg_path:hsa05010", "kegg_path:hsa04150", "kegg_path:hsa04934", "kegg_path:hsa05224", "kegg_path:hsa04550", "kegg_path:hsa05165", "R-HSA-500792", "kegg_path:hsa05217", "kegg_path:hsa04310", "R-HSA-195721", "R-HSA-373080", "kegg_path:hsa05225", "R-HSA-162582", "R-HSA-372790", "kegg_path:hsa04916", "kegg_path:hsa05022", "R-HSA-3238698", "kegg_path:hsa05226", "kegg_path:hsa05200", "kegg_path:hsa04934", "kegg_path:hsa04150", "kegg_path:hsa04550", "kegg_path:hsa05165", "kegg_path:hsa04390" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O14904", "ensembl_id": "ENSG00000143816", "entrez_id": "7483", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.881515" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "739" }, { "type": "SmallVariant", "id": "1328" }, { "type": "SmallVariant", "id": "1585" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WNT9A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WNT9A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "482" }, { "type": "GeneCombination", "id": "510" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/WNT9A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/WNT9A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/WNT9A/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }