Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/440/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FLRT1", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-9006934", "R-HSA-190236", "R-HSA-162582", "R-HSA-5654687", "R-HSA-5654736" ], "essential_gene": null, "status": "CU", "uniprot_acc": "A0A6E1VY70", "ensembl_id": "ENSG00000126500", "entrez_id": "23769", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.845660" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1399" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLRT1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "440" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FLRT1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FLRT1/?format=api" } }, { "type": "Gene", "id": "PDE1B", "attributes": { "go_molecular_function": [ "protein binding", "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity", "cyclic-nucleotide phosphodiesterase activity", "calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity", "3',5'-cyclic-nucleotide phosphodiesterase activity", "3',5'-cyclic-AMP phosphodiesterase activity", "3',5'-cyclic-GMP phosphodiesterase activity" ], "pathway_id": [ "kegg_path:hsa04020", "R-HSA-111885", "kegg_path:hsa04740", "kegg_path:hsa05032", "R-HSA-418555", "R-HSA-111997", "R-HSA-392154", "kegg_path:hsa04924", "R-HSA-111996", "R-HSA-418346", "R-HSA-418457", "kegg_path:hsa00230", "R-HSA-111933", "R-HSA-418594", "kegg_path:hsa04924", "kegg_path:hsa00230", "kegg_path:hsa04020", "kegg_path:hsa04740", "R-HSA-162582", "R-HSA-372790", "R-HSA-9006925", "kegg_path:hsa05032", "kegg_path:hsa01100", "R-HSA-109582", "kegg_path:hsa04742", "R-HSA-388396", "kegg_path:hsa01100", "kegg_path:hsa04742", "R-HSA-111957", "R-HSA-1489509", "R-HSA-112040", "R-HSA-112043" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q01064", "ensembl_id": "ENSG00000123360", "entrez_id": "5153", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.987430" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1400" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PDE1B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PDE1B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "440" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PDE1B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PDE1B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PDE1B/?format=api" } }, { "type": "Gene", "id": "SMARCA2", "attributes": { "go_molecular_function": [ "transcription coactivator activity", "protein binding", "ATP hydrolysis activity", "ATP binding", "transcription cis-regulatory region binding", "histone binding", "ATP-dependent activity, acting on DNA" ], "pathway_id": [ "R-HSA-3247509", "R-HSA-73857", "R-HSA-8939243", "kegg_path:hsa04714", "R-HSA-3214858", "R-HSA-212436", "R-HSA-74160", "kegg_path:hsa05225", "R-HSA-4839726", "R-HSA-8878171" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P51531", "ensembl_id": "ENSG00000080503", "entrez_id": "6595", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.482749" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1398" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMARCA2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMARCA2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "440" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMARCA2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMARCA2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMARCA2/?format=api" } }, { "type": "Gene", "id": "SMARCA5", "attributes": { "go_molecular_function": [ "protein binding", "ATP binding", "nucleotide binding", "hydrolase activity", "helicase activity" ], "pathway_id": [ "R-HSA-427413", "R-HSA-1640170", "R-HSA-5250913", "R-HSA-5250924", "R-HSA-606279", "R-HSA-5250941", "R-HSA-212165", "R-HSA-73886", "R-HSA-73894", "R-HSA-5693532", "R-HSA-5693565", "R-HSA-5693606", "R-HSA-774815", "R-HSA-74160" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60264", "ensembl_id": "ENSG00000153147", "entrez_id": "8467", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.748630" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1397" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMARCA5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMARCA5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "440" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMARCA5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMARCA5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMARCA5/?format=api" } }, { "type": "Gene", "id": "TNIK", "attributes": { "go_molecular_function": [ "protein serine/threonine kinase activity", "protein binding", "protein serine kinase activity" ], "pathway_id": [ "R-HSA-2262752", "R-HSA-2559583", "R-HSA-8953897", "R-HSA-2559580" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9UKE5", "ensembl_id": "ENSG00000154310", "entrez_id": "23043", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.302393" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1396" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TNIK/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TNIK/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "440" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TNIK/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TNIK/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TNIK/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }