Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/216/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ARHGEF28", "attributes": { "go_molecular_function": [ "['guanyl-nucleotide exchange factor activity', 'metal ion binding', 'RNA binding']" ], "pathway_id": [ "kegg_path:hsa05135", "R-HSA-1266738", "R-HSA-2682334", "R-HSA-3928662", "R-HSA-422475", "R-HSA-9675108" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q8N1W1", "ensembl_id": "None", "entrez_id": "ENSG00000214944", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.410101" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "639" }, { "type": "SmallVariant", "id": "3415" }, { "type": "SmallVariant", "id": "3417" }, { "type": "SmallVariant", "id": "3429" }, { "type": "SmallVariant", "id": "3437" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGEF28/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGEF28/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "1145" }, { "type": "GeneCombination", "id": "1146" }, { "type": "GeneCombination", "id": "1150" }, { "type": "GeneCombination", "id": "1153" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGEF28/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGEF28/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGEF28/?format=api" } }, { "type": "Gene", "id": "AVPR2", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-382551", "kegg_path:hsa04072", "R-HSA-5619115", "R-HSA-5653656", "R-HSA-8856828", "R-HSA-388396", "R-HSA-1643685", "R-HSA-388479", "R-HSA-162582", "R-HSA-372790", "R-HSA-445717", "R-HSA-500792", "R-HSA-8856825", "R-HSA-9036092", "R-HSA-9664433", "R-HSA-418555", "R-HSA-5619102", "kegg_path:hsa04080", "R-HSA-373076", "R-HSA-9660821", "R-HSA-199991", "kegg_path:hsa04962", "R-HSA-432040", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-375276", "R-HSA-9662851" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P30518", "ensembl_id": "ENSG00000126895", "entrez_id": "554", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.885532" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "640" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AVPR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AVPR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "216" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AVPR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AVPR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AVPR2/?format=api" } }, { "type": "Gene", "id": "EPHB3", "attributes": { "go_molecular_function": [ "transferase activity", "kinase activity", "ATP binding", "ephrin receptor activity", "nucleotide binding", "protein tyrosine kinase activity", "protein kinase activity" ], "pathway_id": [ "R-HSA-9675108", "R-HSA-422475", "R-HSA-1266738", "R-HSA-3928662", "R-HSA-2682334", "R-HSA-3928664", "R-HSA-3928665", "kegg_path:hsa04360" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P54753", "ensembl_id": "ENSG00000182580", "entrez_id": "2049", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.650715" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "641" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EPHB3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EPHB3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "216" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/EPHB3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/EPHB3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/EPHB3/?format=api" } }, { "type": "Gene", "id": "FAM170A", "attributes": { "go_molecular_function": [ "metal ion binding", "DNA binding" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "A1A519", "ensembl_id": "ENSG00000164334", "entrez_id": "340069", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.986392" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "642" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAM170A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAM170A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "216" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FAM170A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FAM170A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FAM170A/?format=api" } }, { "type": "Gene", "id": "POU2F1", "attributes": { "go_molecular_function": [ "protein binding", "sequence-specific DNA binding" ], "pathway_id": [ "R-HSA-449147", "R-HSA-8939211", "R-HSA-9018519", "R-HSA-74160", "R-HSA-6785807", "R-HSA-74158", "R-HSA-162582", "R-HSA-168256", "R-HSA-749476", "R-HSA-1280215", "R-HSA-73857", "kegg_path:hsa05168", "R-HSA-76046", "R-HSA-6807505", "R-HSA-76071", "R-HSA-9006931" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P14859", "ensembl_id": "ENSG00000143190", "entrez_id": "5451", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.893363" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "643" }, { "type": "SmallVariant", "id": "689" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POU2F1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POU2F1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "221" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POU2F1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POU2F1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POU2F1/?format=api" } }, { "type": "Gene", "id": "RDX", "attributes": { "go_molecular_function": [ "cytoskeletal protein binding", "actin binding" ], "pathway_id": [ "kegg_path:hsa05206", "kegg_path:hsa05205", "R-HSA-373760", "R-HSA-9675108", "kegg_path:hsa05206", "R-HSA-422475", "kegg_path:hsa04810", "kegg_path:hsa04530", "kegg_path:hsa04530", "R-HSA-1266738", "kegg_path:hsa04530", "kegg_path:hsa04810", "R-HSA-437239", "kegg_path:hsa05205", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa04810" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "B0YJ88", "ensembl_id": "ENSG00000137710", "entrez_id": "5962", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.663095" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "644" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RDX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RDX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "216" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RDX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RDX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RDX/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 7 } }