Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/410/genes/?format=api
{ "data": [ { "type": "Gene", "id": "BNC2", "attributes": { "go_molecular_function": [ "transcription cis-regulatory region binding", "DNA binding", "protein binding", "metal ion binding" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q6ZN30", "ensembl_id": "ENSG00000173068", "entrez_id": "54796", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.240289" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1288" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BNC2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BNC2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BNC2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BNC2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BNC2/?format=api" } }, { "type": "Gene", "id": "NRP1", "attributes": { "go_molecular_function": [ "vascular endothelial growth factor-activated receptor activity", "protein binding", "metal ion binding" ], "pathway_id": [ "R-HSA-162582", "kegg_path:hsa05171", "R-HSA-399956", "kegg_path:hsa04360", "R-HSA-376176", "R-HSA-373755", "R-HSA-422475", "R-HSA-194138", "R-HSA-373760", "R-HSA-399954", "R-HSA-445144", "R-HSA-9675108", "R-HSA-447041", "kegg_path:hsa05166", "R-HSA-194306", "R-HSA-1266738", "R-HSA-9006934", "R-HSA-399955" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O14786", "ensembl_id": "ENSG00000099250", "entrez_id": "8829", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.297539" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1306" }, { "type": "SmallVariant", "id": "1420" }, { "type": "SmallVariant", "id": "1877" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NRP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NRP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "446" }, { "type": "GeneCombination", "id": "624" }, { "type": "GeneCombination", "id": "676" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NRP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NRP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NRP1/?format=api" } }, { "type": "Gene", "id": "PROP1", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'beta-catenin binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific double-stranded DNA binding', 'protein C-terminus binding', 'protein binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O75360", "ensembl_id": "None", "entrez_id": "ENSG00000175325", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.328145" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2976" }, { "type": "SmallVariant", "id": "40" }, { "type": "SmallVariant", "id": "1307" }, { "type": "SmallVariant", "id": "2906" }, { "type": "SmallVariant", "id": "3189" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "16" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "963" }, { "type": "GeneCombination", "id": "964" }, { "type": "GeneCombination", "id": "992" }, { "type": "GeneCombination", "id": "1065" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PROP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PROP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PROP1/?format=api" } }, { "type": "Gene", "id": "PTPN11", "attributes": { "go_molecular_function": [ "phosphoprotein phosphatase activity", "non-membrane spanning protein tyrosine phosphatase activity", "protein tyrosine phosphatase activity", "hydrolase activity" ], "pathway_id": [ "R-HSA-1170546", "R-HSA-2404192", "R-HSA-9702518", "R-HSA-2219528", "R-HSA-180292", "R-HSA-5654695", "R-HSA-5654712", "R-HSA-109704", "R-HSA-2586552", "R-HSA-5654700", "R-HSA-449147", "R-HSA-373752", "kegg_path:hsa04670", "R-HSA-9645135", "R-HSA-1257604", "kegg_path:hsa04650", "R-HSA-9006925", "kegg_path:hsa05130", "R-HSA-913531", "R-HSA-114604", "R-HSA-177929", "R-HSA-391160", "kegg_path:hsa04014", "R-HSA-5683057", "R-HSA-2428928", "kegg_path:hsa04722", "kegg_path:hsa05120", "R-HSA-1059683", "R-HSA-186763", "kegg_path:hsa04360", "R-HSA-1643685", "R-HSA-1280218", "R-HSA-5654741", "R-HSA-446652", "R-HSA-877312", "R-HSA-6806834", "R-HSA-1280215", "R-HSA-76002", "kegg_path:hsa04625", "R-HSA-418886", "R-HSA-9682385", "R-HSA-186797", "R-HSA-5654736", "R-HSA-1295596", "R-HSA-5654716", "R-HSA-74160", "R-HSA-74752", "R-HSA-166166", "R-HSA-202733", "R-HSA-5684996", "R-HSA-936964", "kegg_path:hsa04630", "R-HSA-74751", "R-HSA-912694", "R-HSA-112411", "R-HSA-8854691", "R-HSA-909733", "R-HSA-418346", "R-HSA-9703648", "R-HSA-432142", "kegg_path:hsa05205", "R-HSA-168898", "R-HSA-5654733", "R-HSA-877300", "R-HSA-1433557", "R-HSA-5654732", "R-HSA-9006115", "R-HSA-8878171", "R-HSA-168256", "R-HSA-5654706", "R-HSA-6783589", "R-HSA-73857", "R-HSA-9008059", "kegg_path:hsa04072", "R-HSA-512988", "R-HSA-5654727", "R-HSA-166016", "R-HSA-5654720", "R-HSA-5654687", "R-HSA-9607240", "R-HSA-1500931", "R-HSA-5654710", "kegg_path:hsa04920", "R-HSA-110056", "kegg_path:hsa05168", "R-HSA-210990", "R-HSA-5654738", "R-HSA-5654743", "R-HSA-9028731", "R-HSA-9675108", "R-HSA-210993", "R-HSA-422475", "R-HSA-212436", "R-HSA-6811558", "R-HSA-2219530", "R-HSA-168249", "R-HSA-2428924", "kegg_path:hsa05211", "kegg_path:hsa04931", "R-HSA-388841", "R-HSA-389948", "R-HSA-5654693", "R-HSA-9006934", "R-HSA-937061", "kegg_path:hsa05220", "R-HSA-190236", "R-HSA-199418", "R-HSA-5654708", "kegg_path:hsa05235", "R-HSA-109582", "R-HSA-8934593", "R-HSA-112409", "R-HSA-5654726", "R-HSA-5663202", "R-HSA-162582", "R-HSA-8853659", "R-HSA-166520", "R-HSA-1266738", "R-HSA-389513", "R-HSA-5654689", "R-HSA-5654696", "R-HSA-112399", "R-HSA-8865999" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q06124", "ensembl_id": "ENSG00000179295", "entrez_id": "5781", "chromosome_number": "12", "lastmodified": "2021-10-18T11:00:44.381685" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "761" }, { "type": "SmallVariant", "id": "1186" }, { "type": "SmallVariant", "id": "1308" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PTPN11/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PTPN11/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "380" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PTPN11/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PTPN11/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PTPN11/?format=api" } }, { "type": "Gene", "id": "MAML1", "attributes": { "go_molecular_function": [], "pathway_id": [ "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9013508", "kegg_path:hsa04330", "R-HSA-8878159", "R-HSA-162582", "R-HSA-1980143", "R-HSA-1912408", "kegg_path:hsa04658", "R-HSA-2197563", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-212436", "R-HSA-9013694", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-1980145", "R-HSA-8941856", "R-HSA-1643685", "R-HSA-2644602", "R-HSA-2644606", "R-HSA-210744", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-186712", "R-HSA-73857", "R-HSA-157118", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q92585", "ensembl_id": "ENSG00000161021", "entrez_id": "9794", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.488997" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "721" }, { "type": "SmallVariant", "id": "1286" }, { "type": "SmallVariant", "id": "1304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML1/?format=api" } }, { "type": "Gene", "id": "MAML3", "attributes": { "go_molecular_function": [ "transcription coactivator activity" ], "pathway_id": [ "R-HSA-157118", "R-HSA-186712", "R-HSA-73857", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-1912422", "R-HSA-2894862", "R-HSA-9012852", "R-HSA-2644602", "R-HSA-1643685", "R-HSA-8941856", "R-HSA-210744", "R-HSA-2644606", "R-HSA-1266738", "kegg_path:hsa05165", "kegg_path:hsa04658", "R-HSA-2197563", "R-HSA-1980145", "R-HSA-2122947", "R-HSA-9013695", "R-HSA-212436", "R-HSA-9013694", "R-HSA-9013508", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-1912408", "R-HSA-162582", "R-HSA-1980143", "kegg_path:hsa04330", "R-HSA-8878159" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q96JK9", "ensembl_id": "ENSG00000196782", "entrez_id": "55534", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.620397" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "730" }, { "type": "SmallVariant", "id": "755" }, { "type": "SmallVariant", "id": "1305" }, { "type": "SmallVariant", "id": "1312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAML3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAML3/?format=api" } }, { "type": "Gene", "id": "IRX5", "attributes": { "go_molecular_function": [ "vitamin D binding", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P78411", "ensembl_id": "ENSG00000176842", "entrez_id": "10265", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.786497" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1291" }, { "type": "SmallVariant", "id": "1302" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRX5/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRX5/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRX5/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRX5/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IRX5/?format=api" } }, { "type": "Gene", "id": "ATF3", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "transcription cis-regulatory region binding", "DNA-binding transcription repressor activity, RNA polymerase II-specific", "protein heterodimerization activity", "sequence-specific double-stranded DNA binding", "protein homodimerization activity", "DNA-binding transcription factor activity, RNA polymerase II-specific", "DNA-binding transcription factor activity", "DNA binding" ], "pathway_id": [ "R-HSA-381119", "R-HSA-2262752", "R-HSA-380994", "R-HSA-381042", "R-HSA-392499", "R-HSA-9633012", "R-HSA-8953897", "R-HSA-9648895" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P18847", "ensembl_id": "ENSG00000162772", "entrez_id": "467", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.943884" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1295" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATF3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATF3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATF3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATF3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATF3/?format=api" } }, { "type": "Gene", "id": "FRAS1", "attributes": { "go_molecular_function": [ "extracellular matrix structural constituent", "metal ion binding" ], "pathway_id": [ "kegg_path:hsa04512" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q86XX4", "ensembl_id": "ENSG00000138759", "entrez_id": "80144", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.949161" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "709" }, { "type": "SmallVariant", "id": "740" }, { "type": "SmallVariant", "id": "750" }, { "type": "SmallVariant", "id": "751" }, { "type": "SmallVariant", "id": "756" }, { "type": "SmallVariant", "id": "766" }, { "type": "SmallVariant", "id": "1299" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FRAS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "227" }, { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FRAS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FRAS1/?format=api" } }, { "type": "Gene", "id": "IRX6", "attributes": { "go_molecular_function": [ "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "protein binding", "DNA-binding transcription factor activity, RNA polymerase II-specific" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "P78412", "ensembl_id": "ENSG00000159387", "entrez_id": "79190", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.955466" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1303" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRX6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRX6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "410" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/IRX6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/IRX6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/IRX6/?format=api" } }, { "type": "Gene", "id": "CYP1A1", "attributes": { "go_molecular_function": [ "oxygen binding", "lyase activity", "hydroperoxy icosatetraenoate dehydratase activity", "aromatase activity", "metal ion binding", "monooxygenase activity", "oxidoreductase activity" ], "pathway_id": [ "kegg_path:hsa04913", "kegg_path:hsa04913", "R-HSA-8978868", "R-HSA-2142670", "R-HSA-1430728", "R-HSA-2142816", "R-HSA-9018677", "kegg_path:hsa05204", "kegg_path:hsa05204", "R-HSA-1989781", "R-HSA-211859", "kegg_path:hsa00380", "kegg_path:hsa00380", "R-HSA-211897", "R-HSA-211945", "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-556833", "R-HSA-9018681", "kegg_path:hsa00830", "kegg_path:hsa00830", "R-HSA-211981", "R-HSA-2142753", "R-HSA-9018678", "kegg_path:hsa00980", "kegg_path:hsa00980", "R-HSA-400206" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P04798", "ensembl_id": "ENSG00000140465", "entrez_id": "1543", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.968652" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "738" }, { "type": "SmallVariant", "id": "743" }, { "type": "SmallVariant", "id": "1269" }, { "type": "SmallVariant", "id": "1296" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP1A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP1A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": 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