Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/515/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ALDH1A2", "attributes": { "go_molecular_function": [ "['aldehyde dehydrogenase (NAD+) activity', 'retinal dehydrogenase activity', 'retinal binding', '3-chloroallyl aldehyde dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00830", "kegg_path:hsa01100", "R-HSA-162582", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-9006931" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O94788", "ensembl_id": "None", "entrez_id": "ENSG00000128918", "chromosome_number": "15", "lastmodified": "2021-10-18T11:00:44.353012" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1602" }, { "type": "SmallVariant", "id": "3577" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1A2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1A2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1A2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALDH1A2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALDH1A2/?format=api" } }, { "type": "Gene", "id": "BHMT", "attributes": { "go_molecular_function": [ "transferase activity", "zinc ion binding", "methyltransferase activity", "metal ion binding", "betaine-homocysteine S-methyltransferase activity" ], "pathway_id": [ "R-HSA-71291", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-1614635", "kegg_path:hsa00260", "R-HSA-6798163", "kegg_path:hsa00270" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q93088", "ensembl_id": "ENSG00000145692", "entrez_id": "635", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.602607" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1579" }, { "type": "SmallVariant", "id": "1603" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BHMT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BHMT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "508" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "532" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/BHMT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/BHMT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/BHMT/?format=api" } }, { "type": "Gene", "id": "COBL", "attributes": { "go_molecular_function": [ "actin monomer binding", "actin binding", "protein binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O75128", "ensembl_id": "ENSG00000106078", "entrez_id": "23242", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.994636" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1554" }, { "type": "SmallVariant", "id": "1604" }, { "type": "SmallVariant", "id": "1659" }, { "type": "SmallVariant", "id": "1674" }, { "type": "SmallVariant", "id": "1681" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COBL/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "499" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "539" }, { "type": "GeneCombination", "id": "545" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/COBL/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/COBL/?format=api" } }, { "type": "Gene", "id": "CUBN", "attributes": { "go_molecular_function": [ "signaling receptor activity", "cobalamin binding", "cargo receptor activity", "calcium ion binding", "metal ion binding" ], "pathway_id": [ "R-HSA-174824", "R-HSA-382551", "R-HSA-1430728", "R-HSA-3359462", "R-HSA-556833", "R-HSA-3359463", "R-HSA-3296482", "R-HSA-1643685", "R-HSA-196849", "kegg_path:hsa04977", "R-HSA-196854", "R-HSA-8964011", "R-HSA-196741", "R-HSA-3296469", "R-HSA-5668914", "R-HSA-8957322", "R-HSA-8964043", "R-HSA-196791" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60494", "ensembl_id": "ENSG00000107611", "entrez_id": "8029", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.733343" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1516" }, { "type": "SmallVariant", "id": "1524" }, { "type": "SmallVariant", "id": "1563" }, { "type": "SmallVariant", "id": "1601" }, { "type": "SmallVariant", "id": "1609" }, { "type": "SmallVariant", "id": "1677" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUBN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "487" }, { "type": "GeneCombination", "id": "489" }, { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "515" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "547" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CUBN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CUBN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }