Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1278/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MYH9", "attributes": { "go_molecular_function": [ "['protein homodimerization activity', 'integrin binding', 'calmodulin binding', 'cadherin binding', 'protein binding', 'RNA binding', 'ADP binding', 'protein domain specific binding', 'cytoskeletal motor activity', 'protein-membrane adaptor activity', 'actin binding', 'microfilament motor activity', 'actin filament binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa04270", "kegg_path:hsa04530", "kegg_path:hsa04810", "kegg_path:hsa05130", "kegg_path:hsa04270", "kegg_path:hsa04530", "kegg_path:hsa04810", "kegg_path:hsa05130", "R-HSA-1266738", "R-HSA-1445148", "R-HSA-162582", "R-HSA-1643685", "R-HSA-168249", "R-HSA-168256", "R-HSA-194315", "R-HSA-195258", "R-HSA-199991", "R-HSA-2029480", "R-HSA-2029482", "R-HSA-2682334", "R-HSA-373755", "R-HSA-3928663", "R-HSA-400685", "R-HSA-416572", "R-HSA-422475", "R-HSA-5625740", "R-HSA-5625900", "R-HSA-5627117", "R-HSA-5627123", "R-HSA-5653656", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9662834", "R-HSA-9662851", "R-HSA-9664407", "R-HSA-9664417", "R-HSA-9664422", "R-HSA-9664433", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35579", "ensembl_id": "None", "entrez_id": "ENSG00000100345", "chromosome_number": "22", "lastmodified": "2024-02-29T15:02:21.117869" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3771" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYH9/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYH9/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1278" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYH9/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYH9/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYH9/?format=api" } }, { "type": "Gene", "id": "MYO5A", "attributes": { "go_molecular_function": [ "['small GTPase binding', 'calmodulin binding', 'protein binding', 'RNA binding', 'microfilament motor activity', 'actin filament binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa05130", "R-HSA-1445148", "R-HSA-1643685", "R-HSA-168249", "R-HSA-168256", "R-HSA-199991", "R-HSA-2029480", "R-HSA-2029482", "R-HSA-264876", "R-HSA-2980736", "R-HSA-392499", "R-HSA-5653656", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9664407", "R-HSA-9664417", "R-HSA-9664422" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y4I1", "ensembl_id": "None", "entrez_id": "ENSG00000197535", "chromosome_number": "15", "lastmodified": "2024-02-29T15:02:21.109242" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3769" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO5A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO5A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "1277" }, { "type": "GeneCombination", "id": "1278" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MYO5A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MYO5A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MYO5A/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }