Gene Combination Instance – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genecombinations/74/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": {
        "type": "GeneCombination",
        "id": "74",
        "attributes": {
            "gene_relationship": [
                "Involved in the same disease",
                "Directly interacting",
                "Same pathway",
                "Similar function"
            ],
            "protein_interactions": [
                "(FGA, FGG)"
            ],
            "common_pathways": [
                "MAPK family signaling cascades",
                "Integrin cell surface interactions",
                "signaling and aggregation",
                "Common Pathway of Fibrin Clot Formation",
                "Signaling by RAS mutants",
                "Coronavirus disease - COVID-19",
                "Hemostasis",
                "MAP2K and MAPK activation",
                "GRB2:SOS provides linkage to MAPK signaling for Integrins",
                "Signaling by high-kinase activity BRAF mutants",
                "Signaling by RAF1 mutants",
                "Extracellular matrix organization",
                "Signaling downstream of RAS mutants",
                "Regulation of TLR by endogenous ligand",
                "Neutrophil extracellular trap formation",
                "Complement and coagulation cascades",
                "RAF/MAP kinase cascade",
                "Platelet Aggregation (Plug Formation)",
                "Platelet activation",
                "Metabolism of proteins",
                "Signaling by BRAF and RAF fusions",
                "p130Cas linkage to MAPK signaling for integrins",
                "Formation of Fibrin Clot (Clotting Cascade)",
                "Platelet activation",
                "MAPK1/MAPK3 signaling",
                "Oncogenic MAPK signaling",
                "Signaling by moderate kinase activity BRAF mutants",
                "Platelet degranulation",
                "Immune System",
                "Response to elevated platelet cytosolic Ca2+",
                "Paradoxical activation of RAF signaling by kinase inactive BRAF",
                "Integrin signaling",
                "Post-translational protein modification",
                "Innate Immune System",
                "Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)",
                "Disease",
                "Diseases of signal transduction by growth factor receptors and second messengers",
                "Signal Transduction"
            ],
            "genecomb_metascore": 2,
            "lastmodified": "2021-10-18T11:00:48.534297"
        },
        "relationships": {
            "combination_set": {
                "meta": {
                    "count": 1
                },
                "data": [
                    {
                        "type": "Combination",
                        "id": "OLI099"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/74/relationships/combination_set?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/74/combinations/?format=api"
                }
            },
            "genes": {
                "meta": {
                    "count": 2
                },
                "data": [
                    {
                        "type": "Gene",
                        "id": "FGA"
                    },
                    {
                        "type": "Gene",
                        "id": "FGG"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/74/relationships/genes?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/74/genes/?format=api"
                }
            }
        },
        "links": {
            "self": "https://olida.ibsquare.be/api/genecombinations/74/?format=api"
        }
    }
}