Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/385/genes/?format=api
{ "data": [ { "type": "Gene", "id": "AKR1C3", "attributes": { "go_molecular_function": [ "['geranylgeranyl reductase activity', '15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity', 'ketosteroid monooxygenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'androsterone dehydrogenase activity', '17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'ketoreductase activity', 'steroid dehydrogenase activity', 'D-threo-aldose 1-dehydrogenase activity', 'oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor', 'prostaglandin-F synthase activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'dihydrotestosterone 17-beta-dehydrogenase activity', 'phenanthrene 9,10-monooxygenase activity', 'prostaglandin H2 endoperoxidase reductase activity', 'delta4-3-oxosteroid 5beta-reductase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'NAD-retinol dehydrogenase activity', 'bile acid binding', 'alditol:NADP+ 1-oxidoreductase activity', 'retinal dehydrogenase activity', 'NADP-retinol dehydrogenase activity', 'testosterone dehydrogenase (NAD+) activity', 'prostaglandin D2 11-ketoreductase activity', 'aldo-keto reductase (NADP) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2142753", "R-HSA-2162123", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-8978868", "R-HSA-9006931", "R-HSA-975634", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa00140", "kegg_path:hsa00590", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa04913", "R-HSA-1430728", "R-HSA-162582", "R-HSA-192105", "R-HSA-193368", "R-HSA-193775", "R-HSA-193807", "R-HSA-194068", "R-HSA-196854", "R-HSA-2142753", "R-HSA-2162123", "R-HSA-2187338", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594", "R-HSA-5362517", "R-HSA-5365859", "R-HSA-556833", "R-HSA-6806667", "R-HSA-8957322", "R-HSA-8978868", "R-HSA-9006931", "R-HSA-975634" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P42330", "ensembl_id": "None", "entrez_id": "ENSG00000196139", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.479228" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1200" }, { "type": "SmallVariant", "id": "3220" }, { "type": "SmallVariant", "id": "3245" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1087" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/AKR1C3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/AKR1C3/?format=api" } }, { "type": "Gene", "id": "DOCK8", "attributes": { "go_molecular_function": [ "guanyl-nucleotide exchange factor activity", "protein binding" ], "pathway_id": [ "R-HSA-983231", "R-HSA-109582" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8NF50", "ensembl_id": "ENSG00000107099", "entrez_id": "81704", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.684765" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1201" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DOCK8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DOCK8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "385" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DOCK8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DOCK8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DOCK8/?format=api" } }, { "type": "Gene", "id": "FSHR", "attributes": { "go_molecular_function": [ "['follicle-stimulating hormone receptor activity', 'G protein-coupled peptide receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04913", "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04913", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-418555", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A1D5RMN4", "ensembl_id": "None", "entrez_id": "ENSG00000170820", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.419525" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1202" }, { "type": "SmallVariant", "id": "2256" }, { "type": "SmallVariant", "id": "2284" }, { "type": "SmallVariant", "id": "3657" }, { "type": "SmallVariant", "id": "3658" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FSHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "767" }, { "type": "GeneCombination", "id": "1230" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FSHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/?format=api" } }, { "type": "Gene", "id": "NCOR1", "attributes": { "go_molecular_function": [ "transcription corepressor activity", "DNA binding" ], "pathway_id": [ "R-HSA-1980143", "R-HSA-9609646", "R-HSA-2151201", "R-HSA-1236394", "R-HSA-9609690", "R-HSA-9022537", "R-HSA-350054", "R-HSA-9005891", "R-HSA-556833", "R-HSA-9024446", "kegg_path:hsa01522", "R-HSA-212436", "R-HSA-400253", "R-HSA-3214815", "R-HSA-5617472", "R-HSA-9022692", "R-HSA-2644606", "kegg_path:hsa04919", "R-HSA-1592230", "R-HSA-2644602", "kegg_path:hsa05202", "R-HSA-381340", "R-HSA-5619507", "R-HSA-2894862", "R-HSA-9005895", "R-HSA-9029569", "R-HSA-1989781", "R-HSA-2173793", "R-HSA-9006934", "R-HSA-9623433", "R-HSA-157118", "R-HSA-9697154", "R-HSA-1430728", "R-HSA-73857", "R-HSA-8986944", "R-HSA-2644603", "R-HSA-2894858", "R-HSA-383280", "R-HSA-162582", "R-HSA-4839726", "R-HSA-9006936", "R-HSA-1251985", "R-HSA-1852241", "R-HSA-5663202", "R-HSA-74160", "kegg_path:hsa01522", "R-HSA-2122947", "R-HSA-5663205", "R-HSA-9006931", "R-HSA-1266738", "R-HSA-1368071", "R-HSA-400206", "R-HSA-3247509", "R-HSA-9675151", "kegg_path:hsa04919", "R-HSA-2173795", "R-HSA-1643685", "kegg_path:hsa05202", "R-HSA-170834" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O75376", "ensembl_id": "ENSG00000141027", "entrez_id": "9611", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.924689" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1203" }, { "type": "SmallVariant", "id": "1204" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "385" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR1/?format=api" } }, { "type": "Gene", "id": "NR5A1", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', 'zinc ion binding', 'enzyme binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'nuclear receptor activity', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding', 'phospholipid binding', 'transcription coregulator binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04927", "kegg_path:hsa04934", "kegg_path:hsa04927", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-452723", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-9690406" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13285", "ensembl_id": "None", "entrez_id": "ENSG00000136931", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.221369" }, "relationships": { "variant_set": { "meta": { "count": 19 }, "data": [ { "type": "SmallVariant", "id": "861" }, { "type": "SmallVariant", "id": "863" }, { "type": "SmallVariant", "id": "1197" }, { "type": "SmallVariant", "id": "1199" }, { "type": "SmallVariant", "id": "1206" }, { "type": "SmallVariant", "id": "1214" }, { "type": "SmallVariant", "id": "1442" }, { "type": "SmallVariant", "id": "1445" }, { "type": "SmallVariant", "id": "1697" }, { "type": "SmallVariant", "id": "2169" }, { "type": "SmallVariant", "id": "2269" }, { "type": "SmallVariant", "id": "2278" }, { "type": "SmallVariant", "id": "3160" }, { "type": "SmallVariant", "id": "3257" }, { "type": "SmallVariant", "id": "3272" }, { "type": "SmallVariant", "id": "3275" }, { "type": "SmallVariant", "id": "3411" }, { "type": "SmallVariant", "id": "3413" }, { "type": "SmallVariant", "id": "3667" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "384" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "459" }, { "type": "GeneCombination", "id": "460" }, { "type": "GeneCombination", "id": "554" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "766" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "1055" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1144" }, { "type": "GeneCombination", "id": "1235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/?format=api" } }, { "type": "Gene", "id": "POR", "attributes": { "go_molecular_function": [ "['NADPH-hemoprotein reductase activity', 'nitric oxide dioxygenase activity', 'hydrolase activity', 'enzyme binding', 'oxidoreductase activity', 'NADP binding', 'flavin adenine dinucleotide binding', 'electron transfer activity', 'protein binding', 'cytochrome-b5 reductase activity, acting on NAD(P)H', 'iron-cytochrome-c reductase activity', 'FMN binding']" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945", "R-HSA-1430728", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P16435", "ensembl_id": "None", "entrez_id": "ENSG00000127948", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.656385" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "707" }, { "type": "SmallVariant", "id": "1205" }, { "type": "SmallVariant", "id": "2166" }, { "type": "SmallVariant", "id": "2178" }, { "type": "SmallVariant", "id": "3205" }, { "type": "SmallVariant", "id": "3315" }, { "type": "SmallVariant", "id": "3708" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "226" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1115" }, { "type": "GeneCombination", "id": "1255" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }