Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/870/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ACE", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'chloride ion binding', 'metallopeptidase activity', 'exopeptidase activity', 'bradykinin receptor binding', 'heterocyclic compound binding', 'endopeptidase activity', 'tripeptidyl-peptidase activity', 'mitogen-activated protein kinase binding', 'peptidyl-dipeptidase activity', 'mitogen-activated protein kinase kinase binding', 'carboxypeptidase activity', 'metallodipeptidase activity']" ], "pathway_id": [ "kegg_path:hsa04614", "kegg_path:hsa04924", "kegg_path:hsa05142", "kegg_path:hsa05171", "kegg_path:hsa05410", "R-HSA-2022377", "R-HSA-2980736", "R-HSA-392499", "kegg_path:hsa04614", "kegg_path:hsa04924", "kegg_path:hsa05142", "kegg_path:hsa05171", "kegg_path:hsa05410", "R-HSA-2022377", "R-HSA-2980736", "R-HSA-392499" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "F6X3S4", "ensembl_id": "None", "entrez_id": "ENSG00000159640", "chromosome_number": "17", "lastmodified": "2023-05-16T12:02:32.387754" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2612" }, { "type": "SmallVariant", "id": "2618" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ACE/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ACE/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "867" }, { "type": "GeneCombination", "id": "870" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ACE/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ACE/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ACE/?format=api" } }, { "type": "Gene", "id": "ALPG", "attributes": { "go_molecular_function": [ "['alkaline phosphatase activity', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa00730", "kegg_path:hsa00790", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-163125", "R-HSA-392499", "R-HSA-597592" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P10696", "ensembl_id": "None", "entrez_id": "ENSG00000163286", "chromosome_number": "2", "lastmodified": "2023-05-16T12:02:32.411868" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2619" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALPG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALPG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "870" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ALPG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ALPG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ALPG/?format=api" } }, { "type": "Gene", "id": "CYP17A1", "attributes": { "go_molecular_function": [ "['steroid 17-alpha-monooxygenase activity', 'iron ion binding', 'heme binding', '17-alpha-hydroxyprogesterone aldolase activity', 'oxygen binding']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa04917", "kegg_path:hsa04927", "kegg_path:hsa04934", "R-HSA-1430728", "R-HSA-1643685", "R-HSA-193048", "R-HSA-194002", "R-HSA-196071", "R-HSA-556833", "R-HSA-5579028", "R-HSA-5579029", "R-HSA-5668914", "R-HSA-8957322", "kegg_path:hsa00140", "kegg_path:hsa01100", "kegg_path:hsa04913", "kegg_path:hsa04917", "kegg_path:hsa04927", "kegg_path:hsa04934" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P05093", "ensembl_id": "None", "entrez_id": "ENSG00000148795", "chromosome_number": "10", "lastmodified": "2023-05-16T12:02:32.415584" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2620" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP17A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP17A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "870" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CYP17A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CYP17A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CYP17A1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }