Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/981/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ANOS1", "attributes": { "go_molecular_function": [ "['heparin binding', 'extracellular matrix structural constituent', 'serine-type endopeptidase inhibitor activity', 'protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-190236", "R-HSA-190242", "R-HSA-190373", "R-HSA-5654726", "R-HSA-5654736", "R-HSA-9006934" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P23352", "ensembl_id": "None", "entrez_id": "ENSG00000011201", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.754255" }, "relationships": { "variant_set": { "meta": { "count": 36 }, "data": [ { "type": "CopyNumberVariant", "id": "3399" }, { "type": "CopyNumberVariant", "id": "1795" }, { "type": "CopyNumberVariant", "id": "1867" }, { "type": "SmallVariant", "id": "245" }, { "type": "SmallVariant", "id": "309" }, { "type": "SmallVariant", "id": "399" }, { "type": "SmallVariant", "id": "559" }, { "type": "SmallVariant", "id": "777" }, { "type": "SmallVariant", "id": "849" }, { "type": "SmallVariant", "id": "855" }, { "type": "SmallVariant", "id": "973" }, { "type": "SmallVariant", "id": "975" }, { "type": "SmallVariant", "id": "1083" }, { "type": "SmallVariant", "id": "1832" }, { "type": "SmallVariant", "id": "1833" }, { "type": "SmallVariant", "id": "1863" }, { "type": "SmallVariant", "id": "1876" }, { "type": "SmallVariant", "id": "1927" }, { "type": "SmallVariant", "id": "2202" }, { "type": "SmallVariant", "id": "2395" }, { "type": "SmallVariant", "id": "2405" }, { "type": "SmallVariant", "id": "2710" }, { "type": "SmallVariant", "id": "2727" }, { "type": "SmallVariant", "id": "2731" }, { "type": "SmallVariant", "id": "2767" }, { "type": "SmallVariant", "id": "2827" }, { "type": "SmallVariant", "id": "2916" }, { "type": "SmallVariant", "id": "2947" }, { "type": "SmallVariant", "id": "2957" }, { "type": "SmallVariant", "id": "2962" }, { "type": "SmallVariant", "id": "2966" }, { "type": "SmallVariant", "id": "2987" }, { "type": "SmallVariant", "id": "2988" }, { "type": "SmallVariant", "id": "2993" }, { "type": "SmallVariant", "id": "2997" }, { "type": "SmallVariant", "id": "3158" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANOS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 29 }, "data": [ { "type": "GeneCombination", "id": "191" }, { "type": "GeneCombination", "id": "264" }, { "type": "GeneCombination", "id": "261" }, { "type": "GeneCombination", "id": "354" }, { "type": "GeneCombination", "id": "594" }, { "type": "GeneCombination", "id": "620" }, { "type": "GeneCombination", "id": "623" }, { "type": "GeneCombination", "id": "624" }, { "type": "GeneCombination", "id": "642" }, { "type": "GeneCombination", "id": "651" }, { "type": "GeneCombination", "id": "901" }, { "type": "GeneCombination", "id": "907" }, { "type": "GeneCombination", "id": "312" }, { "type": "GeneCombination", "id": "90" }, { "type": "GeneCombination", "id": "243" }, { "type": "GeneCombination", "id": "968" }, { "type": "GeneCombination", "id": "969" }, { "type": "GeneCombination", "id": "975" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "984" }, { "type": "GeneCombination", "id": "986" }, { "type": "GeneCombination", "id": "988" }, { "type": "GeneCombination", "id": "992" }, { "type": "GeneCombination", "id": "997" }, { "type": "GeneCombination", "id": "998" }, { "type": "GeneCombination", "id": "1000" }, { "type": "GeneCombination", "id": "1001" }, { "type": "GeneCombination", "id": "1054" }, { "type": "GeneCombination", "id": "1088" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ANOS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ANOS1/?format=api" } }, { "type": "Gene", "id": "CCDC141", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000163492", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.678885" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "769" }, { "type": "SmallVariant", "id": "1417" }, { "type": "SmallVariant", "id": "2578" }, { "type": "SmallVariant", "id": "2890" }, { "type": "SmallVariant", "id": "2892" }, { "type": "SmallVariant", "id": "2915" }, { "type": "SmallVariant", "id": "2922" }, { "type": "SmallVariant", "id": "2950" }, { "type": "SmallVariant", "id": "3014" }, { "type": "SmallVariant", "id": "3165" }, { "type": "SmallVariant", "id": "3167" }, { "type": "SmallVariant", "id": "3170" }, { "type": "SmallVariant", "id": "3181" }, { "type": "SmallVariant", "id": "3256" }, { "type": "SmallVariant", "id": "3268" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CCDC141/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CCDC141/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "241" }, { "type": "GeneCombination", "id": "445" }, { "type": "GeneCombination", "id": "858" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "958" }, { "type": "GeneCombination", "id": "967" }, { "type": "GeneCombination", "id": "970" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "1006" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1057" }, { "type": "GeneCombination", "id": "1058" }, { "type": "GeneCombination", "id": "1062" }, { "type": "GeneCombination", "id": "1093" }, { "type": "GeneCombination", "id": "1099" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CCDC141/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CCDC141/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CCDC141/?format=api" } }, { "type": "Gene", "id": "DCC", "attributes": { "go_molecular_function": [ "['transmembrane signaling receptor activity', 'protein binding', 'netrin receptor activity']" ], "pathway_id": [ "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05210", "R-HSA-109581", "R-HSA-1266738", "R-HSA-373752", "R-HSA-376172", "R-HSA-376176", "R-HSA-418885", "R-HSA-418886", "R-HSA-418889", "R-HSA-418890", "R-HSA-422475", "R-HSA-428542", "R-HSA-5357769", "R-HSA-5357801", "R-HSA-9675108", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05210" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P43146", "ensembl_id": "None", "entrez_id": "ENSG00000187323", "chromosome_number": "18", "lastmodified": "2021-10-18T11:00:44.731182" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "1847" }, { "type": "SmallVariant", "id": "1872" }, { "type": "SmallVariant", "id": "1907" }, { "type": "SmallVariant", "id": "1955" }, { "type": "SmallVariant", "id": "2884" }, { "type": "SmallVariant", "id": "2949" }, { "type": "SmallVariant", "id": "2989" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCC/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCC/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "613" }, { "type": "GeneCombination", "id": "622" }, { "type": "GeneCombination", "id": "640" }, { "type": "GeneCombination", "id": "667" }, { "type": "GeneCombination", "id": "954" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "998" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCC/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCC/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DCC/?format=api" } }, { "type": "Gene", "id": "GNRH1", "attributes": { "go_molecular_function": [ "['hormone activity', 'gonadotropin-releasing hormone receptor binding', 'gonadotropin hormone-releasing hormone activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04912", "kegg_path:hsa04929", "R-HSA-162582", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-416476", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01148", "ensembl_id": "None", "entrez_id": "ENSG00000147437", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.344397" }, "relationships": { "variant_set": { "meta": { "count": 8 }, "data": [ { "type": "SmallVariant", "id": "774" }, { "type": "SmallVariant", "id": "816" }, { "type": "SmallVariant", "id": "1974" }, { "type": "SmallVariant", "id": "2510" }, { "type": "SmallVariant", "id": "2776" }, { "type": "SmallVariant", "id": "2948" }, { "type": "SmallVariant", "id": "3377" }, { "type": "SmallVariant", "id": "3767" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "257" }, { "type": "GeneCombination", "id": "289" }, { "type": "GeneCombination", "id": "851" }, { "type": "GeneCombination", "id": "928" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "678" }, { "type": "GeneCombination", "id": "1276" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GNRH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GNRH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GNRH1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }