Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/767/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ADAMTS4", "attributes": { "go_molecular_function": [ "protease binding", "protein binding", "peptidase activity", "metal ion binding", "metallopeptidase activity", "metalloendopeptidase activity" ], "pathway_id": [ "R-HSA-3906995", "R-HSA-1474244", "R-HSA-1474228", "R-HSA-5083635", "R-HSA-1643685", "R-HSA-3781865", "R-HSA-597592", "R-HSA-5173105", "R-HSA-392499", "R-HSA-5668914", "R-HSA-5173214" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O75173", "ensembl_id": "ENSG00000158859", "entrez_id": "9507", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:58.102075" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2282" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS4/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADAMTS4/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "767" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS4/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ADAMTS4/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ADAMTS4/?format=api" } }, { "type": "Gene", "id": "DHCR24", "attributes": { "go_molecular_function": [ "delta24(24-1) sterol reductase activity", "delta24-sterol reductase activity", "protein binding", "enzyme binding", "FAD binding", "oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor", "peptide antigen binding" ], "pathway_id": [ "R-HSA-8957322", "R-HSA-6807047", "kegg_path:hsa00100", "kegg_path:hsa01100", "R-HSA-191273", "R-HSA-556833", "R-HSA-6807062", "R-HSA-1430728" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15392", "ensembl_id": "ENSG00000116133", "entrez_id": "1718", "chromosome_number": "1", "lastmodified": "2022-08-04T14:15:00.050386" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2283" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DHCR24/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DHCR24/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "767" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DHCR24/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DHCR24/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DHCR24/?format=api" } }, { "type": "Gene", "id": "FSHR", "attributes": { "go_molecular_function": [ "['follicle-stimulating hormone receptor activity', 'G protein-coupled peptide receptor activity', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04913", "kegg_path:hsa04024", "kegg_path:hsa04080", "kegg_path:hsa04913", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375281", "R-HSA-388396", "R-HSA-418555", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A1D5RMN4", "ensembl_id": "None", "entrez_id": "ENSG00000170820", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.419525" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1202" }, { "type": "SmallVariant", "id": "2256" }, { "type": "SmallVariant", "id": "2284" }, { "type": "SmallVariant", "id": "3657" }, { "type": "SmallVariant", "id": "3658" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FSHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "760" }, { "type": "GeneCombination", "id": "767" }, { "type": "GeneCombination", "id": "1230" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FSHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FSHR/?format=api" } }, { "type": "Gene", "id": "RAD52", "attributes": { "go_molecular_function": [ "single-stranded DNA binding", "identical protein binding", "DNA binding", "protein binding" ], "pathway_id": [ "kegg_path:hsa03440", "R-HSA-2990846", "R-HSA-3108232", "kegg_path:hsa03440", "R-HSA-5693567", "R-HSA-5693538", "R-HSA-73894", "R-HSA-5685938", "R-HSA-5693532", "R-HSA-3108214", "R-HSA-392499", "R-HSA-597592" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P43351", "ensembl_id": "ENSG00000002016", "entrez_id": "5893", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:59.103162" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2259" }, { "type": "SmallVariant", "id": "2285" }, { "type": "SmallVariant", "id": "2310" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD52/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "767" }, { "type": "GeneCombination", "id": "776" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RAD52/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RAD52/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }