Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1116/genes/?format=api
{ "data": [ { "type": "Gene", "id": "HSD17B6", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'androstan-3-alpha,17-beta-diol dehydrogenase activity', '5alpha-androstane-3beta,17beta-diol dehydrogenase activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity', 'testosterone dehydrogenase (NAD+) activity', '17-beta-hydroxysteroid dehydrogenase (NAD+) activity', 'NAD-retinol dehydrogenase activity', 'electron transfer activity', 'oxidoreductase activity', 'catalytic activity', 'androsterone dehydrogenase activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "kegg_path:hsa00140", "kegg_path:hsa00830", "kegg_path:hsa01100", "kegg_path:hsa01240", "R-HSA-162582", "R-HSA-2187338", "R-HSA-2453902", "R-HSA-372790", "R-HSA-388396", "R-HSA-418594" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O14756", "ensembl_id": "None", "entrez_id": "ENSG00000025423", "chromosome_number": "12", "lastmodified": "2023-05-16T12:02:33.587797" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "3207" }, { "type": "SmallVariant", "id": "3227" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1079" }, { "type": "GeneCombination", "id": "1098" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B6/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B6/?format=api" } }, { "type": "Gene", "id": "LHX3", "attributes": { "go_molecular_function": [ "['sequence-specific DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'metal ion binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-376176", "R-HSA-422475", "R-HSA-9010553", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9UBR4", "ensembl_id": "None", "entrez_id": "ENSG00000107187", "chromosome_number": "9", "lastmodified": "2023-05-16T12:02:33.700770" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3320" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LHX3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LHX3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LHX3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LHX3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LHX3/?format=api" } }, { "type": "Gene", "id": "PTCH1", "attributes": { "go_molecular_function": [ "['cyclin binding', 'patched binding', 'smoothened binding', 'protein-containing complex binding', 'hedgehog family protein binding', 'protein binding', 'heparin binding', 'cholesterol binding', 'hedgehog receptor activity']" ], "pathway_id": [ "kegg_path:hsa04024", "kegg_path:hsa04340", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "R-HSA-162582", "R-HSA-372790", "R-HSA-373080", "R-HSA-500792", "R-HSA-5358351", "R-HSA-5610787", "R-HSA-5632681", "R-HSA-5632684", "R-HSA-5635838" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13635", "ensembl_id": "None", "entrez_id": "ENSG00000185920", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.300396" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "1471" }, { "type": "SmallVariant", "id": "1502" }, { "type": "SmallVariant", "id": "1512" }, { "type": "SmallVariant", "id": "3316" }, { "type": "SmallVariant", "id": "3317" }, { "type": "SmallVariant", "id": "3318" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PTCH1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PTCH1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "470" }, { "type": "GeneCombination", "id": "481" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "1116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PTCH1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PTCH1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PTCH1/?format=api" } }, { "type": "Gene", "id": "RXFP2", "attributes": { "go_molecular_function": [ "['G protein-coupled peptide receptor activity', 'protein-hormone receptor activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04926", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-418555", "R-HSA-444821", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8WXD0", "ensembl_id": "None", "entrez_id": "ENSG00000133105", "chromosome_number": "13", "lastmodified": "2023-05-16T12:02:33.575225" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3193" }, { "type": "SmallVariant", "id": "3251" }, { "type": "SmallVariant", "id": "3287" }, { "type": "SmallVariant", "id": "3319" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXFP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1106" }, { "type": "GeneCombination", "id": "1116" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXFP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }