Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/727/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FUS", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', \"mRNA 3'-UTR binding\", 'transcription coregulator activity', 'protein binding', 'RNA binding', 'transcription coactivator activity', 'metal ion binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202", "R-HSA-72163", "R-HSA-72172", "R-HSA-72203", "R-HSA-8953854", "kegg_path:hsa03013", "kegg_path:hsa03015", "kegg_path:hsa03040", "kegg_path:hsa05014", "kegg_path:hsa05022", "kegg_path:hsa05202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35637", "ensembl_id": "None", "entrez_id": "ENSG00000089280", "chromosome_number": "16", "lastmodified": "2021-10-18T11:00:44.299468" }, "relationships": { "variant_set": { "meta": { "count": 13 }, "data": [ { "type": "SmallVariant", "id": "536" }, { "type": "SmallVariant", "id": "539" }, { "type": "SmallVariant", "id": "1373" }, { "type": "SmallVariant", "id": "1374" }, { "type": "SmallVariant", "id": "1389" }, { "type": "SmallVariant", "id": "1391" }, { "type": "SmallVariant", "id": "1432" }, { "type": "SmallVariant", "id": "1708" }, { "type": "SmallVariant", "id": "1711" }, { "type": "SmallVariant", "id": "1806" }, { "type": "SmallVariant", "id": "2101" }, { "type": "SmallVariant", "id": "3436" }, { "type": "SmallVariant", "id": "3606" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "182" }, { "type": "GeneCombination", "id": "431" }, { "type": "GeneCombination", "id": "432" }, { "type": "GeneCombination", "id": "438" }, { "type": "GeneCombination", "id": "453" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "560" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "913" }, { "type": "GeneCombination", "id": "914" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FUS/?format=api" } }, { "type": "Gene", "id": "NEK1", "attributes": { "go_molecular_function": [ "['protein tyrosine kinase activity', 'protein serine kinase activity', 'protein serine/threonine/tyrosine kinase activity', 'protein binding', 'protein kinase activity', 'protein serine/threonine kinase activity', '14-3-3 protein binding', 'metal ion binding', 'kinase activity', 'ATP binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q96PY6", "ensembl_id": "None", "entrez_id": "ENSG00000137601", "chromosome_number": "4", "lastmodified": "2021-10-18T11:00:44.841783" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "976" }, { "type": "SmallVariant", "id": "1369" }, { "type": "SmallVariant", "id": "1814" }, { "type": "SmallVariant", "id": "2052" }, { "type": "SmallVariant", "id": "2056" }, { "type": "SmallVariant", "id": "2062" }, { "type": "SmallVariant", "id": "2085" }, { "type": "SmallVariant", "id": "2096" }, { "type": "SmallVariant", "id": "2132" }, { "type": "SmallVariant", "id": "2138" }, { "type": "SmallVariant", "id": "2188" }, { "type": "SmallVariant", "id": "2190" }, { "type": "SmallVariant", "id": "2191" }, { "type": "SmallVariant", "id": "2193" }, { "type": "SmallVariant", "id": "2194" }, { "type": "SmallVariant", "id": "2196" }, { "type": "SmallVariant", "id": "2198" }, { "type": "SmallVariant", "id": "3352" }, { "type": "SmallVariant", "id": "3414" }, { "type": "SmallVariant", "id": "3425" }, { "type": "SmallVariant", "id": "3427" }, { "type": "SmallVariant", "id": "3430" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEK1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "748" }, { "type": "GeneCombination", "id": "749" }, { "type": "GeneCombination", "id": "313" }, { "type": "GeneCombination", "id": "428" }, { "type": "GeneCombination", "id": "599" }, { "type": "GeneCombination", "id": "600" }, { "type": "GeneCombination", "id": "707" }, { "type": "GeneCombination", "id": "708" }, { "type": "GeneCombination", "id": "711" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "734" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "735" }, { "type": "GeneCombination", "id": "1128" }, { "type": "GeneCombination", "id": "1145" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NEK1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NEK1/?format=api" } }, { "type": "Gene", "id": "PON1", "attributes": { "go_molecular_function": [ "protein homodimerization activity", "calcium ion binding", "acyl-L-homoserine-lactone lactonohydrolase activity", "phospholipid binding", "aryldialkylphosphatase activity", "arylesterase activity" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-556833", "R-HSA-2142688", "R-HSA-8978868", "R-HSA-2142753" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P27169", "ensembl_id": "ENSG00000005421", "entrez_id": "5444", "chromosome_number": "7", "lastmodified": "2022-08-04T14:14:58.919703" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "2086" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PON1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PON1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "727" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/PON1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/PON1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/PON1/?format=api" } }, { "type": "Gene", "id": "SETX", "attributes": { "go_molecular_function": [ "['DNA binding', 'hydrolase activity', 'protein binding', 'RNA binding', 'DNA helicase activity', 'transcription termination site sequence-specific DNA binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa05014" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q7Z333", "ensembl_id": "None", "entrez_id": "ENSG00000107290", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.749548" }, "relationships": { "variant_set": { "meta": { "count": 23 }, "data": [ { "type": "SmallVariant", "id": "528" }, { "type": "SmallVariant", "id": "538" }, { "type": "SmallVariant", "id": "544" }, { "type": "SmallVariant", "id": "546" }, { "type": "SmallVariant", "id": "547" }, { "type": "SmallVariant", "id": "921" }, { "type": "SmallVariant", "id": "929" }, { "type": "SmallVariant", "id": "1381" }, { "type": "SmallVariant", "id": "1425" }, { "type": "SmallVariant", "id": "1431" }, { "type": "SmallVariant", "id": "1439" }, { "type": "SmallVariant", "id": "1726" }, { "type": "SmallVariant", "id": "1727" }, { "type": "SmallVariant", "id": "2041" }, { "type": "SmallVariant", "id": "2044" }, { "type": "SmallVariant", "id": "2054" }, { "type": "SmallVariant", "id": "2099" }, { "type": "SmallVariant", "id": "2100" }, { "type": "SmallVariant", "id": "2637" }, { "type": "SmallVariant", "id": "3435" }, { "type": "SmallVariant", "id": "3443" }, { "type": "SmallVariant", "id": "3608" }, { "type": "SmallVariant", "id": "3609" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "177" }, { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "181" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "186" }, { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "290" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "456" }, { "type": "GeneCombination", "id": "458" }, { "type": "GeneCombination", "id": "568" }, { "type": "GeneCombination", "id": "703" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1156" }, { "type": "GeneCombination", "id": "1213" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/?format=api" } }, { "type": "Gene", "id": "SOD1", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'small GTPase binding', 'superoxide dismutase activity', 'protein binding', 'protein phosphatase 2B binding', 'copper ion binding', 'chaperone binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04146", "kegg_path:hsa04213", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05020", "kegg_path:hsa05022", "R-HSA-109582", "R-HSA-114608", "R-HSA-1280215", "R-HSA-168256", "R-HSA-2262752", "R-HSA-3299685", "R-HSA-447115", "R-HSA-449147", "R-HSA-76002", "R-HSA-76005", "R-HSA-8950505", "R-HSA-8953897", "R-HSA-9020591" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P00441", "ensembl_id": "None", "entrez_id": "ENSG00000142168", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.427208" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "1693" }, { "type": "SmallVariant", "id": "525" }, { "type": "SmallVariant", "id": "527" }, { "type": "SmallVariant", "id": "541" }, { "type": "SmallVariant", "id": "638" }, { "type": "SmallVariant", "id": "693" }, { "type": "SmallVariant", "id": "936" }, { "type": "SmallVariant", "id": "937" }, { "type": "SmallVariant", "id": "1379" }, { "type": "SmallVariant", "id": "1428" }, { "type": "SmallVariant", "id": "1709" }, { "type": "SmallVariant", "id": "2035" }, { "type": "SmallVariant", "id": "2039" }, { "type": "SmallVariant", "id": "2050" }, { "type": "SmallVariant", "id": "2189" }, { "type": "SmallVariant", "id": "3418" }, { "type": "SmallVariant", "id": "3426" }, { "type": "SmallVariant", "id": "3432" }, { "type": "SmallVariant", "id": "3446" }, { "type": "SmallVariant", "id": "3600" }, { "type": "SmallVariant", "id": "3603" }, { "type": "SmallVariant", "id": "3605" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 36 }, "data": [ { "type": "GeneCombination", "id": "173" }, { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "184" }, { "type": "GeneCombination", "id": "216" }, { "type": "GeneCombination", "id": "217" }, { "type": "GeneCombination", "id": "218" }, { "type": "GeneCombination", "id": "219" }, { "type": "GeneCombination", "id": "220" }, { "type": "GeneCombination", "id": "221" }, { "type": "GeneCombination", "id": "222" }, { "type": "GeneCombination", "id": "223" }, { "type": "GeneCombination", "id": "297" }, { "type": "GeneCombination", "id": "298" }, { "type": "GeneCombination", "id": "434" }, { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "552" }, { "type": "GeneCombination", "id": "559" }, { "type": "GeneCombination", "id": "561" }, { "type": "GeneCombination", "id": "562" }, { "type": "GeneCombination", "id": "699" }, { "type": "GeneCombination", "id": "700" }, { "type": "GeneCombination", "id": "701" }, { "type": "GeneCombination", "id": "702" }, { "type": "GeneCombination", "id": "706" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "726" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "723" }, { "type": "GeneCombination", "id": "722" }, { "type": "GeneCombination", "id": "721" }, { "type": "GeneCombination", "id": "747" }, { "type": "GeneCombination", "id": "1151" }, { "type": "GeneCombination", "id": "1154" }, { "type": "GeneCombination", "id": "1158" }, { "type": "GeneCombination", "id": "1212" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOD1/?format=api" } }, { "type": "Gene", "id": "VAPB", "attributes": { "go_molecular_function": [ "protein homodimerization activity", "protein binding", "enzyme binding", "beta-tubulin binding", "protein heterodimerization activity", "microtubule binding", "cadherin binding", "FFAT motif binding" ], "pathway_id": [ "R-HSA-1430728", "kegg_path:hsa04979", "R-HSA-428157", "kegg_path:hsa04979", "R-HSA-556833", "kegg_path:hsa05022", "kegg_path:hsa05014", "kegg_path:hsa05014", "kegg_path:hsa05022", "R-HSA-1660661" ], "essential_gene": null, "status": "CU", "uniprot_acc": "O95292", "ensembl_id": "ENSG00000124164", "entrez_id": "9217", "chromosome_number": "20", "lastmodified": "2021-10-18T11:00:44.638178" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "533" }, { "type": "SmallVariant", "id": "1819" }, { "type": "SmallVariant", "id": "2092" }, { "type": "SmallVariant", "id": "2094" }, { "type": "SmallVariant", "id": "2102" }, { "type": "SmallVariant", "id": "2103" }, { "type": "SmallVariant", "id": "2104" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VAPB/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VAPB/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "178" }, { "type": "GeneCombination", "id": "183" }, { "type": "GeneCombination", "id": "603" }, { "type": "GeneCombination", "id": "724" }, { "type": "GeneCombination", "id": "725" }, { "type": "GeneCombination", "id": "727" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/VAPB/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/VAPB/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/VAPB/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 6 } }