Gene Combination Instance
This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.
GET /api/genecombinations/88/?format=api
{ "data": { "type": "GeneCombination", "id": "88", "attributes": { "gene_relationship": [ "Similar function", "Directly interacting", "Same pathway", "Relevant pathways for phenotype" ], "protein_interactions": [ "(PSMB4, PSMB9)" ], "common_pathways": [ "M Phase", "Metabolism of amino acids and derivatives", "Regulation of RAS by GAPs", "Apoptosis", "Axon guidance", "Synthesis of DNA", "Defective CFTR causes cystic fibrosis", "ABC transporter disorders", "APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1", "RUNX1 regulates transcription of genes involved in differentiation of HSCs", "Fc epsilon receptor (FCERI) signaling", "S Phase", "Signaling by WNT", "Hedgehog on state", "Signaling by the B Cell Receptor (BCR)", "Regulation of APC/C activators between G1/S and early anaphase", "Transport of small molecules", "Mitotic G1 phase and G1/S transition", "Regulation of expression of SLITs and ROBOs", "Mitotic Anaphase", "Ubiquitin Mediated Degradation of Phosphorylated Cdc25A", "Hh mutants abrogate ligand secretion", "Transcriptional regulation by RUNX3", "Cell Cycle", "MAPK6/MAPK4 signaling", "CLEC7A (Dectin-1) signaling", "Regulation of RUNX2 expression and activity", "p53-Independent G1/S DNA damage checkpoint", "Cytokine Signaling in Immune system", "Class I MHC mediated antigen processing & presentation", "Stabilization of p53", "Proteasome", "PCP/CE pathway", "FBXL7 down-regulates AURKA during mitotic entry and in early mitosis", "HIV Infection", "Disease", "p53-Dependent G1/S DNA damage checkpoint", "Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha", "CDT1 association with the CDC6:ORC:origin complex", "GLI3 is processed to GLI3R by the proteasome", "Activation of NF-kappaB in B cells", "APC/C:Cdc20 mediated degradation of Securin", "Intracellular signaling by second messengers", "Gene expression (Transcription)", "Autodegradation of Cdh1 by Cdh1:APC/C", "Separation of Sister Chromatids", "CDK-mediated phosphorylation and removal of Cdc6", "DNA Replication Pre-Initiation", "PIP3 activates AKT signaling", "Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins", "Cyclin E associated events during G1/S transition", "Metabolism of polyamines", "Orc1 removal from chromatin", "SCF(Skp2)-mediated degradation of p27/p21", "Hh mutants are degraded by ERAD", "SCF-beta-TrCP mediated degradation of Emi1", "Cellular responses to stress", "Transcriptional regulation by RUNX1", "Metabolism of proteins", "Dectin-1 mediated noncanonical NF-kB signaling", "Regulation of activated PAK-2p34 by proteasome mediated degradation", "Degradation of GLI1 by the proteasome", "G2/M Transition", "MAPK1/MAPK3 signaling", "Antigen processing: Ubiquitination & Proteasome degradation", "Degradation of DVL", "Cell Cycle Checkpoints", "Hedgehog off state", "Assembly of the pre-replicative complex", "TCR signaling", "ER-Phagosome pathway", "AUF1 (hnRNP D0) binds and destabilizes mRNA", "Generic Transcription Pathway", "TNFR2 non-canonical NF-kB pathway", "Switching of origins to a post-replicative state", "Programmed Cell Death", "Host Interactions of HIV factors", "Infectious disease", "Regulation of PTEN stability and activity", "G2/M Checkpoints", "UCH proteinases", "Mitotic Metaphase and Anaphase", "The role of GTSE1 in G2/M progression after G2 checkpoint", "Regulation of mRNA stability by proteins that bind AU-rich elements", "G1/S DNA Damage Checkpoints", "Developmental Biology", "Hedgehog ligand biogenesis", "p53-Independent DNA Damage Response", "Asymmetric localization of PCP proteins", "Downstream signaling events of B Cell Receptor (BCR)", "APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint", "Nervous system development", "Cdc20:Phospho-APC/C mediated degradation of Cyclin A", "Cross-presentation of soluble exogenous antigens (endosomes)", "Cellular responses to external stimuli", "Interleukin-1 family signaling", "ABC-family proteins mediated transport", "Signaling by NOTCH4", "DNA Replication", "Signaling by Interleukins", "APC/C-mediated degradation of cell cycle proteins", "p53-Dependent G1 DNA Damage Response", "Neddylation", "Deubiquitination", "TCF dependent signaling in response to WNT", "Degradation of beta-catenin by the destruction complex", "Ub-specific processing proteases", "Disorders of transmembrane transporters", "Regulation of Apoptosis", "Adaptive Immune System", "Signaling by Hedgehog", "MAPK family signaling cascades", "Mitotic", "Antigen processing-Cross presentation", "Ubiquitin-dependent degradation of Cyclin D", "Signaling by NOTCH", "Interleukin-1 signaling", "Vpu mediated degradation of CD4", "C-type lectin receptors (CLRs)", "RAF/MAP kinase cascade", "RNA Polymerase II Transcription", "PTEN Regulation", "Metabolism of RNA", "Immune System", "Signaling by ROBO receptors", "APC/C:Cdc20 mediated degradation of mitotic proteins", "Degradation of AXIN", "Mitotic G2-G2/M phases", "Innate Immune System", "Vif-mediated degradation of APOBEC3G", "NIK-->noncanonical NF-kB signaling", "Beta-catenin independent WNT signaling", "FCERI mediated NF-kB activation", "Cyclin A:Cdk2-associated events at S phase entry", "Regulation of RUNX3 expression and activity", "Regulation of ornithine decarboxylase (ODC)", "Diseases of signal transduction by growth factor receptors and second messengers", "Autodegradation of the E3 ubiquitin ligase COP1", "Regulation of mitotic cell cycle", "Downstream TCR signaling", "G1/S Transition", "Negative regulation of NOTCH4 signaling", "Transcriptional regulation by RUNX2", "Metabolism", "Cell Cycle", "Cellular response to hypoxia", "Signal Transduction" ], "genecomb_metascore": 3, "lastmodified": "2021-10-18T11:00:49.129108" }, "relationships": { "combination_set": { "meta": { "count": 1 }, "data": [ { "type": "Combination", "id": "OLI117" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/88/relationships/combination_set?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/88/combinations/?format=api" } }, "genes": { "meta": { "count": 2 }, "data": [ { "type": "Gene", "id": "PSMB4" }, { "type": "Gene", "id": "PSMB9" } ], "links": { "self": "https://olida.ibsquare.be/api/genecombinations/88/relationships/genes?format=api", "related": "https://olida.ibsquare.be/api/genecombinations/88/genes/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genecombinations/88/?format=api" } } }