Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/763/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FIGLA", "attributes": { "go_molecular_function": [ "protein binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "E-box binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "sequence-specific double-stranded DNA binding", "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "bHLH transcription factor binding", "protein dimerization activity" ], "pathway_id": [ "None", "None" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q6QHK4", "ensembl_id": "ENSG00000183733", "entrez_id": "344018", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.513830" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "194" }, { "type": "SmallVariant", "id": "2267" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FIGLA/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FIGLA/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "69" }, { "type": "GeneCombination", "id": "763" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FIGLA/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FIGLA/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FIGLA/?format=api" } }, { "type": "Gene", "id": "NCOR2", "attributes": { "go_molecular_function": [ "Notch binding", "protein binding", "DNA binding", "glucocorticoid receptor binding", "protein N-terminus binding", "transcription corepressor activity", "histone deacetylase binding", "chromatin binding", "retinoid X receptor binding", "protein-containing complex binding" ], "pathway_id": [ "R-HSA-2644603", "R-HSA-2894858", "R-HSA-157118", "R-HSA-9697154", "R-HSA-2173793", "R-HSA-9029569", "R-HSA-170834", "kegg_path:hsa05169", "R-HSA-1643685", "R-HSA-2173795", "R-HSA-9675151", "R-HSA-3247509", "R-HSA-9022692", "R-HSA-1266738", "R-HSA-3214815", "R-HSA-400206", "R-HSA-212436", "R-HSA-5663205", "R-HSA-9006931", "R-HSA-2122947", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-556833", "R-HSA-9024446", "R-HSA-9005891", "R-HSA-350054", "R-HSA-5663202", "R-HSA-74160", "R-HSA-9022537", "R-HSA-9609690", "R-HSA-597592", "R-HSA-9006936", "kegg_path:hsa04330", "R-HSA-4839726", "R-HSA-162582", "R-HSA-1980143", "R-HSA-9609646", "R-HSA-383280", "R-HSA-1430728", "R-HSA-73857", "R-HSA-8986944", "R-HSA-1989781", "R-HSA-9623433", "R-HSA-2894862", "R-HSA-9005895", "R-HSA-3899300", "R-HSA-381340", "R-HSA-392499", "R-HSA-2644602", "R-HSA-2644606" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9Y618", "ensembl_id": "ENSG00000196498", "entrez_id": "9612", "chromosome_number": "12", "lastmodified": "2022-08-04T14:14:58.085323" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "2122" }, { "type": "SmallVariant", "id": "2258" }, { "type": "SmallVariant", "id": "2270" }, { "type": "SmallVariant", "id": "2295" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "731" }, { "type": "GeneCombination", "id": "761" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "770" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NCOR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NCOR2/?format=api" } }, { "type": "Gene", "id": "NOBOX", "attributes": { "go_molecular_function": [ "['DNA-binding transcription factor activity, RNA polymerase II-specific', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "O60393", "ensembl_id": "None", "entrez_id": "ENSG00000106410", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.865997" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "2622" }, { "type": "SmallVariant", "id": "192" }, { "type": "SmallVariant", "id": "193" }, { "type": "SmallVariant", "id": "2268" }, { "type": "SmallVariant", "id": "2323" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOBOX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOBOX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "68" }, { "type": "GeneCombination", "id": "70" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "781" }, { "type": "GeneCombination", "id": "871" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NOBOX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NOBOX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NOBOX/?format=api" } }, { "type": "Gene", "id": "NR5A1", "attributes": { "go_molecular_function": [ "['DNA binding', 'chromatin binding', 'zinc ion binding', 'enzyme binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'nuclear receptor activity', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'sequence-specific DNA binding', 'phospholipid binding', 'transcription coregulator binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [ "kegg_path:hsa04927", "kegg_path:hsa04934", "kegg_path:hsa04927", "kegg_path:hsa04934", "R-HSA-1266738", "R-HSA-212436", "R-HSA-2990846", "R-HSA-3108232", "R-HSA-383280", "R-HSA-392499", "R-HSA-4090294", "R-HSA-452723", "R-HSA-597592", "R-HSA-73857", "R-HSA-74160", "R-HSA-9690406" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q13285", "ensembl_id": "None", "entrez_id": "ENSG00000136931", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.221369" }, "relationships": { "variant_set": { "meta": { "count": 19 }, "data": [ { "type": "SmallVariant", "id": "861" }, { "type": "SmallVariant", "id": "863" }, { "type": "SmallVariant", "id": "1197" }, { "type": "SmallVariant", "id": "1199" }, { "type": "SmallVariant", "id": "1206" }, { "type": "SmallVariant", "id": "1214" }, { "type": "SmallVariant", "id": "1442" }, { "type": "SmallVariant", "id": "1445" }, { "type": "SmallVariant", "id": "1697" }, { "type": "SmallVariant", "id": "2169" }, { "type": "SmallVariant", "id": "2269" }, { "type": "SmallVariant", "id": "2278" }, { "type": "SmallVariant", "id": "3160" }, { "type": "SmallVariant", "id": "3257" }, { "type": "SmallVariant", "id": "3272" }, { "type": "SmallVariant", "id": "3275" }, { "type": "SmallVariant", "id": "3411" }, { "type": "SmallVariant", "id": "3413" }, { "type": "SmallVariant", "id": "3667" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "268" }, { "type": "GeneCombination", "id": "267" }, { "type": "GeneCombination", "id": "384" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "459" }, { "type": "GeneCombination", "id": "460" }, { "type": "GeneCombination", "id": "554" }, { "type": "GeneCombination", "id": "738" }, { "type": "GeneCombination", "id": "766" }, { "type": "GeneCombination", "id": "763" }, { "type": "GeneCombination", "id": "1055" }, { "type": "GeneCombination", "id": "1094" }, { "type": "GeneCombination", "id": "1101" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1144" }, { "type": "GeneCombination", "id": "1235" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR5A1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR5A1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }