Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1122/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MAMLD1", "attributes": { "go_molecular_function": [ "['molecular_function']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695", "R-HSA-1266738", "R-HSA-157118", "R-HSA-162582", "R-HSA-1643685", "R-HSA-186712", "R-HSA-1912408", "R-HSA-1912422", "R-HSA-1980143", "R-HSA-1980145", "R-HSA-210744", "R-HSA-2122947", "R-HSA-212436", "R-HSA-2197563", "R-HSA-2644602", "R-HSA-2644603", "R-HSA-2644606", "R-HSA-2894858", "R-HSA-2894862", "R-HSA-350054", "R-HSA-5663202", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878159", "R-HSA-8941856", "R-HSA-9012852", "R-HSA-9013508", "R-HSA-9013694", "R-HSA-9013695" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q13495", "ensembl_id": "None", "entrez_id": "ENSG00000013619", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.997839" }, "relationships": { "variant_set": { "meta": { "count": 22 }, "data": [ { "type": "SmallVariant", "id": "581" }, { "type": "SmallVariant", "id": "717" }, { "type": "SmallVariant", "id": "722" }, { "type": "SmallVariant", "id": "729" }, { "type": "SmallVariant", "id": "733" }, { "type": "SmallVariant", "id": "736" }, { "type": "SmallVariant", "id": "742" }, { "type": "SmallVariant", "id": "745" }, { "type": "SmallVariant", "id": "752" }, { "type": "SmallVariant", "id": "757" }, { "type": "SmallVariant", "id": "1268" }, { "type": "SmallVariant", "id": "1278" }, { "type": "SmallVariant", "id": "1280" }, { "type": "SmallVariant", "id": "1283" }, { "type": "SmallVariant", "id": "1294" }, { "type": "SmallVariant", "id": "1310" }, { "type": "SmallVariant", "id": "1316" }, { "type": "SmallVariant", "id": "3192" }, { "type": "SmallVariant", "id": "3200" }, { "type": "SmallVariant", "id": "3252" }, { "type": "SmallVariant", "id": "3259" }, { "type": "SmallVariant", "id": "3325" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 26 }, "data": [ { "type": "GeneCombination", "id": "236" }, { "type": "GeneCombination", "id": "240" }, { "type": "GeneCombination", "id": "200" }, { "type": "GeneCombination", "id": "237" }, { "type": "GeneCombination", "id": "238" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "232" }, { "type": "GeneCombination", "id": "233" }, { "type": "GeneCombination", "id": "234" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "239" }, { "type": "GeneCombination", "id": "406" }, { "type": "GeneCombination", "id": "407" }, { "type": "GeneCombination", "id": "408" }, { "type": "GeneCombination", "id": "405" }, { "type": "GeneCombination", "id": "409" }, { "type": "GeneCombination", "id": "410" }, { "type": "GeneCombination", "id": "411" }, { "type": "GeneCombination", "id": "412" }, { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1095" }, { "type": "GeneCombination", "id": "1120" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAMLD1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAMLD1/?format=api" } }, { "type": "Gene", "id": "NRAS", "attributes": { "go_molecular_function": [ "['G protein activity', 'GTP binding', 'protein-containing complex binding', 'protein binding', 'GDP binding', 'GTPase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04062", "kegg_path:hsa04068", "kegg_path:hsa04071", "kegg_path:hsa04072", "kegg_path:hsa04137", "kegg_path:hsa04140", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04210", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04218", "kegg_path:hsa04360", "kegg_path:hsa04370", "kegg_path:hsa04371", "kegg_path:hsa04540", "kegg_path:hsa04550", "kegg_path:hsa04625", "kegg_path:hsa04650", "kegg_path:hsa04660", "kegg_path:hsa04662", "kegg_path:hsa04664", "kegg_path:hsa04714", "kegg_path:hsa04720", "kegg_path:hsa04722", "kegg_path:hsa04725", "kegg_path:hsa04726", "kegg_path:hsa04730", "kegg_path:hsa04810", "kegg_path:hsa04910", "kegg_path:hsa04912", "kegg_path:hsa04915", "kegg_path:hsa04916", "kegg_path:hsa04917", "kegg_path:hsa04919", "kegg_path:hsa04921", "kegg_path:hsa04926", "kegg_path:hsa04929", "kegg_path:hsa04933", "kegg_path:hsa04935", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05034", "kegg_path:hsa05160", "kegg_path:hsa05161", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05166", "kegg_path:hsa05167", "kegg_path:hsa05170", "kegg_path:hsa05200", "kegg_path:hsa05203", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05211", "kegg_path:hsa05213", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05216", "kegg_path:hsa05218", "kegg_path:hsa05219", "kegg_path:hsa05220", "kegg_path:hsa05221", "kegg_path:hsa05223", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235", "R-HSA-109582", "R-HSA-112314", "R-HSA-112315", "R-HSA-112316", "R-HSA-112399", "R-HSA-112412", "R-HSA-1168372", "R-HSA-1169092", "R-HSA-1226099", "R-HSA-1227986", "R-HSA-1227990", "R-HSA-1236382", "R-HSA-1236394", "R-HSA-1250196", "R-HSA-1250347", "R-HSA-1266738", "R-HSA-1280215", "R-HSA-1280218", "R-HSA-1433557", "R-HSA-162582", "R-HSA-1643685", "R-HSA-1643713", "R-HSA-166520", "R-HSA-167044", "R-HSA-168249", "R-HSA-168256", "R-HSA-171007", "R-HSA-177929", "R-HSA-179812", "R-HSA-180336", "R-HSA-186763", "R-HSA-186797", "R-HSA-187037", "R-HSA-187687", "R-HSA-190236", "R-HSA-194138", "R-HSA-1963640", "R-HSA-202733", "R-HSA-210993", "R-HSA-2172127", "R-HSA-2179392", "R-HSA-2404192", "R-HSA-2424491", "R-HSA-2428924", "R-HSA-2428928", "R-HSA-2428933", "R-HSA-2454202", "R-HSA-2871796", "R-HSA-372790", "R-HSA-375165", "R-HSA-388396", "R-HSA-416476", "R-HSA-422475", "R-HSA-438064", "R-HSA-4420097", "R-HSA-442742", "R-HSA-442755", "R-HSA-442982", "R-HSA-5218921", "R-HSA-5621481", "R-HSA-5621575", "R-HSA-5637810", "R-HSA-5637812", "R-HSA-5637815", "R-HSA-5654687", "R-HSA-5654688", "R-HSA-5654693", "R-HSA-5654696", "R-HSA-5654699", "R-HSA-5654700", "R-HSA-5654704", "R-HSA-5654706", "R-HSA-5654708", "R-HSA-5654712", "R-HSA-5654716", "R-HSA-5654719", "R-HSA-5654736", "R-HSA-5654738", "R-HSA-5654741", "R-HSA-5654743", "R-HSA-5655253", "R-HSA-5655291", "R-HSA-5655302", "R-HSA-5655332", "R-HSA-5658442", "R-HSA-5663202", "R-HSA-5673000", "R-HSA-5673001", "R-HSA-5674135", "R-HSA-5675221", "R-HSA-5683057", "R-HSA-5684996", "R-HSA-6798695", "R-HSA-6802946", "R-HSA-6802948", "R-HSA-6802949", "R-HSA-6802952", "R-HSA-6802953", "R-HSA-6802955", "R-HSA-6802957", "R-HSA-6806834", "R-HSA-74751", "R-HSA-74752", "R-HSA-881907", "R-HSA-8848021", "R-HSA-8849471", "R-HSA-8851805", "R-HSA-8853334", "R-HSA-8853338", "R-HSA-8939211", "R-HSA-9006115", "R-HSA-9006335", "R-HSA-9006927", "R-HSA-9006931", "R-HSA-9006934", "R-HSA-9009391", "R-HSA-9026519", "R-HSA-9027284", "R-HSA-9028731", "R-HSA-9034015", "R-HSA-9034864", "R-HSA-9607240", "R-HSA-9634285", "R-HSA-9634635", "R-HSA-9648002", "R-HSA-9649913", "R-HSA-9649948", "R-HSA-9656223", "R-HSA-9664565", "R-HSA-9665348", "R-HSA-9665686", "R-HSA-9669938", "R-HSA-9670439", "R-HSA-9671555", "R-HSA-9673767", "R-HSA-9673770", "R-HSA-9675108", "R-HSA-9682385", "R-HSA-9703465", "R-HSA-9703648", "R-HSA-983705", "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04010", "kegg_path:hsa04012", "kegg_path:hsa04014", "kegg_path:hsa04015", "kegg_path:hsa04062", "kegg_path:hsa04068", "kegg_path:hsa04071", "kegg_path:hsa04072", "kegg_path:hsa04137", "kegg_path:hsa04140", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04210", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04218", "kegg_path:hsa04360", "kegg_path:hsa04370", "kegg_path:hsa04371", "kegg_path:hsa04540", "kegg_path:hsa04550", "kegg_path:hsa04625", "kegg_path:hsa04650", "kegg_path:hsa04660", "kegg_path:hsa04662", "kegg_path:hsa04664", "kegg_path:hsa04714", "kegg_path:hsa04720", "kegg_path:hsa04722", "kegg_path:hsa04725", "kegg_path:hsa04726", "kegg_path:hsa04730", "kegg_path:hsa04810", "kegg_path:hsa04910", "kegg_path:hsa04912", "kegg_path:hsa04915", "kegg_path:hsa04916", "kegg_path:hsa04917", "kegg_path:hsa04919", "kegg_path:hsa04921", "kegg_path:hsa04926", "kegg_path:hsa04929", "kegg_path:hsa04933", "kegg_path:hsa04935", "kegg_path:hsa05010", "kegg_path:hsa05022", "kegg_path:hsa05034", "kegg_path:hsa05160", "kegg_path:hsa05161", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05166", "kegg_path:hsa05167", "kegg_path:hsa05170", "kegg_path:hsa05200", "kegg_path:hsa05203", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05211", "kegg_path:hsa05213", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05216", "kegg_path:hsa05218", "kegg_path:hsa05219", "kegg_path:hsa05220", "kegg_path:hsa05221", "kegg_path:hsa05223", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P01111", "ensembl_id": "None", "entrez_id": "ENSG00000213281", "chromosome_number": "1", "lastmodified": "2023-05-16T12:02:33.704934" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "3328" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NRAS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NRAS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NRAS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NRAS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NRAS/?format=api" } }, { "type": "Gene", "id": "RXFP2", "attributes": { "go_molecular_function": [ "['G protein-coupled peptide receptor activity', 'protein-hormone receptor activity']" ], "pathway_id": [ "kegg_path:hsa04080", "kegg_path:hsa04926", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373076", "R-HSA-375276", "R-HSA-388396", "R-HSA-418555", "R-HSA-444821", "R-HSA-500792", "R-HSA-5663205", "R-HSA-9658195", "R-HSA-9660821", "R-HSA-9662851", "R-HSA-9664433" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8WXD0", "ensembl_id": "None", "entrez_id": "ENSG00000133105", "chromosome_number": "13", "lastmodified": "2023-05-16T12:02:33.575225" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3193" }, { "type": "SmallVariant", "id": "3251" }, { "type": "SmallVariant", "id": "3287" }, { "type": "SmallVariant", "id": "3319" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXFP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "1067" }, { "type": "GeneCombination", "id": "1091" }, { "type": "GeneCombination", "id": "1092" }, { "type": "GeneCombination", "id": "1106" }, { "type": "GeneCombination", "id": "1116" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXFP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RXFP2/?format=api" } }, { "type": "Gene", "id": "SHH", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'patched binding', 'laminin-1 binding', 'calcium ion binding', 'morphogen activity', 'endopeptidase activity', 'protein binding', 'glycosaminoglycan binding']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373080", "R-HSA-500792", "R-HSA-5358346", "R-HSA-5358351", "R-HSA-5362768", "R-HSA-5362798", "R-HSA-5387390", "R-HSA-5632681", "R-HSA-5632684", "R-HSA-5635838", "R-HSA-5658034", "R-HSA-5663202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15465", "ensembl_id": "None", "entrez_id": "ENSG00000164690", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.375806" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "876" }, { "type": "SmallVariant", "id": "1461" }, { "type": "SmallVariant", "id": "1475" }, { "type": "SmallVariant", "id": "1484" }, { "type": "SmallVariant", "id": "1514" }, { "type": "SmallVariant", "id": "2366" }, { "type": "SmallVariant", "id": "3130" }, { "type": "SmallVariant", "id": "3231" }, { "type": "SmallVariant", "id": "3262" }, { "type": "SmallVariant", "id": "3329" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "273" }, { "type": "GeneCombination", "id": "467" }, { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "486" }, { "type": "GeneCombination", "id": "1046" }, { "type": "GeneCombination", "id": "1047" }, { "type": "GeneCombination", "id": "800" }, { "type": "GeneCombination", "id": "801" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1096" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }