Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/475/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CELSR1", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity', 'calcium ion binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NYQ6", "ensembl_id": "None", "entrez_id": "ENSG00000075275", "chromosome_number": "22", "lastmodified": "2021-10-18T11:00:44.610366" }, "relationships": { "variant_set": { "meta": { "count": 18 }, "data": [ { "type": "SmallVariant", "id": "3114" }, { "type": "SmallVariant", "id": "1073" }, { "type": "SmallVariant", "id": "1075" }, { "type": "SmallVariant", "id": "1077" }, { "type": "SmallVariant", "id": "1081" }, { "type": "SmallVariant", "id": "1481" }, { "type": "SmallVariant", "id": "1486" }, { "type": "SmallVariant", "id": "1517" }, { "type": "SmallVariant", "id": "1552" }, { "type": "SmallVariant", "id": "1630" }, { "type": "SmallVariant", "id": "1678" }, { "type": "SmallVariant", "id": "3103" }, { "type": "SmallVariant", "id": "3105" }, { "type": "SmallVariant", "id": "3107" }, { "type": "SmallVariant", "id": "3109" }, { "type": "SmallVariant", "id": "3111" }, { "type": "SmallVariant", "id": "3112" }, { "type": "SmallVariant", "id": "3116" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 13 }, "data": [ { "type": "GeneCombination", "id": "351" }, { "type": "GeneCombination", "id": "352" }, { "type": "GeneCombination", "id": "473" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "487" }, { "type": "GeneCombination", "id": "499" }, { "type": "GeneCombination", "id": "527" }, { "type": "GeneCombination", "id": "538" }, { "type": "GeneCombination", "id": "547" }, { "type": "GeneCombination", "id": "1040" }, { "type": "GeneCombination", "id": "1041" }, { "type": "GeneCombination", "id": "1043" }, { "type": "GeneCombination", "id": "1042" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR1/?format=api" } }, { "type": "Gene", "id": "LRP2", "attributes": { "go_molecular_function": [ "calcium ion binding", "protein binding", "protein transporter activity", "hormone binding", "insulin-like growth factor I binding", "chaperone binding", "cargo receptor activity", "low-density lipoprotein particle receptor activity", "SH3 domain binding" ], "pathway_id": [ "R-HSA-196854", "R-HSA-162582", "R-HSA-372790", "R-HSA-8957322", "R-HSA-2187338", "R-HSA-196791", "R-HSA-6806667", "R-HSA-8856825", "R-HSA-1430728", "kegg_path:hsa04340", "R-HSA-556833", "kegg_path:hsa04979", "R-HSA-5653656", "R-HSA-8856828", "kegg_path:hsa04918", "R-HSA-418594", "R-HSA-975634", "R-HSA-199991", "R-HSA-388396" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P98164", "ensembl_id": "ENSG00000081479", "entrez_id": "4036", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.952832" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1468" }, { "type": "SmallVariant", "id": "1485" }, { "type": "SmallVariant", "id": "1993" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "469" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "686" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/LRP2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/LRP2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/LRP2/?format=api" } }, { "type": "Gene", "id": "MKS1", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [ "R-HSA-162582", "R-HSA-1852241", "R-HSA-5358351", "R-HSA-5610787", "R-HSA-5617833", "R-HSA-5620912" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NXB0", "ensembl_id": "None", "entrez_id": "ENSG00000011143", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.625374" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1487" }, { "type": "SmallVariant", "id": "2469" }, { "type": "SmallVariant", "id": "3032" }, { "type": "SmallVariant", "id": "3038" }, { "type": "SmallVariant", "id": "3501" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MKS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MKS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "834" }, { "type": "GeneCombination", "id": "1012" }, { "type": "GeneCombination", "id": "1016" }, { "type": "GeneCombination", "id": "1179" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MKS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MKS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MKS1/?format=api" } }, { "type": "Gene", "id": "SHH", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'patched binding', 'laminin-1 binding', 'calcium ion binding', 'morphogen activity', 'endopeptidase activity', 'protein binding', 'glycosaminoglycan binding']" ], "pathway_id": [ "kegg_path:hsa04340", "kegg_path:hsa04360", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05217", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-1643685", "R-HSA-372790", "R-HSA-373080", "R-HSA-500792", "R-HSA-5358346", "R-HSA-5358351", "R-HSA-5362768", "R-HSA-5362798", "R-HSA-5387390", "R-HSA-5632681", "R-HSA-5632684", "R-HSA-5635838", "R-HSA-5658034", "R-HSA-5663202" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15465", "ensembl_id": "None", "entrez_id": "ENSG00000164690", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.375806" }, "relationships": { "variant_set": { "meta": { "count": 10 }, "data": [ { "type": "SmallVariant", "id": "876" }, { "type": "SmallVariant", "id": "1461" }, { "type": "SmallVariant", "id": "1475" }, { "type": "SmallVariant", "id": "1484" }, { "type": "SmallVariant", "id": "1514" }, { "type": "SmallVariant", "id": "2366" }, { "type": "SmallVariant", "id": "3130" }, { "type": "SmallVariant", "id": "3231" }, { "type": "SmallVariant", "id": "3262" }, { "type": "SmallVariant", "id": "3329" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 12 }, "data": [ { "type": "GeneCombination", "id": "273" }, { "type": "GeneCombination", "id": "467" }, { "type": "GeneCombination", "id": "472" }, { "type": "GeneCombination", "id": "475" }, { "type": "GeneCombination", "id": "486" }, { "type": "GeneCombination", "id": "1046" }, { "type": "GeneCombination", "id": "1047" }, { "type": "GeneCombination", "id": "800" }, { "type": "GeneCombination", "id": "801" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1096" }, { "type": "GeneCombination", "id": "1122" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SHH/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SHH/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }