Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/681/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ARHGAP36", "attributes": { "go_molecular_function": [ "GTPase activator activity" ], "pathway_id": [ "R-HSA-194315", "R-HSA-194840", "R-HSA-162582" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q6ZRI8", "ensembl_id": "ENSG00000147256", "entrez_id": "158763", "chromosome_number": "X", "lastmodified": "2022-08-04T14:14:57.425062" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1983" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGAP36/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGAP36/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "681" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGAP36/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ARHGAP36/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ARHGAP36/?format=api" } }, { "type": "Gene", "id": "RXRG", "attributes": { "go_molecular_function": [ "steroid hormone receptor activity", "protein binding", "DNA-binding transcription factor activity, RNA polymerase II-specific", "retinoic acid-responsive element binding", "sequence-specific double-stranded DNA binding", "nuclear receptor activity", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "zinc ion binding" ], "pathway_id": [ "kegg_path:hsa05223", "kegg_path:hsa04920", "kegg_path:hsa05216", "kegg_path:hsa05226", "R-HSA-162582", "R-HSA-74160", "kegg_path:hsa05202", "kegg_path:hsa04659", "kegg_path:hsa05200", "R-HSA-212436", "R-HSA-9006931", "kegg_path:hsa03320", "R-HSA-383280", "R-HSA-73857", "kegg_path:hsa04928", "kegg_path:hsa05222", "kegg_path:hsa04919", "R-HSA-5362517" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P48443", "ensembl_id": "ENSG00000143171", "entrez_id": "6258", "chromosome_number": "1", "lastmodified": "2022-08-04T14:14:59.169792" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1982" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXRG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXRG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "681" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RXRG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RXRG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RXRG/?format=api" } }, { "type": "Gene", "id": "TKTL1", "attributes": { "go_molecular_function": [ "metal ion binding", "thiamine pyrophosphate binding", "transketolase activity" ], "pathway_id": [ "kegg_path:hsa01200", "kegg_path:hsa01100", "kegg_path:hsa00030", "kegg_path:hsa01230", "kegg_path:hsa01100", "kegg_path:hsa01200", "kegg_path:hsa00030", "kegg_path:hsa01230" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P51854", "ensembl_id": "ENSG00000007350", "entrez_id": "8277", "chromosome_number": "X", "lastmodified": "2022-08-04T14:14:58.377464" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1984" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TKTL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TKTL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "681" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TKTL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TKTL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TKTL1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }