Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/967/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CCDC141", "attributes": { "go_molecular_function": [ "['protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "None", "ensembl_id": "None", "entrez_id": "ENSG00000163492", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.678885" }, "relationships": { "variant_set": { "meta": { "count": 15 }, "data": [ { "type": "SmallVariant", "id": "769" }, { "type": "SmallVariant", "id": "1417" }, { "type": "SmallVariant", "id": "2578" }, { "type": "SmallVariant", "id": "2890" }, { "type": "SmallVariant", "id": "2892" }, { "type": "SmallVariant", "id": "2915" }, { "type": "SmallVariant", "id": "2922" }, { "type": "SmallVariant", "id": "2950" }, { "type": "SmallVariant", "id": "3014" }, { "type": "SmallVariant", "id": "3165" }, { "type": "SmallVariant", "id": "3167" }, { "type": "SmallVariant", "id": "3170" }, { "type": "SmallVariant", "id": "3181" }, { "type": "SmallVariant", "id": "3256" }, { "type": "SmallVariant", "id": "3268" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CCDC141/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CCDC141/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 15 }, "data": [ { "type": "GeneCombination", "id": "241" }, { "type": "GeneCombination", "id": "445" }, { "type": "GeneCombination", "id": "858" }, { "type": "GeneCombination", "id": "957" }, { "type": "GeneCombination", "id": "958" }, { "type": "GeneCombination", "id": "967" }, { "type": "GeneCombination", "id": "970" }, { "type": "GeneCombination", "id": "981" }, { "type": "GeneCombination", "id": "1006" }, { "type": "GeneCombination", "id": "1056" }, { "type": "GeneCombination", "id": "1057" }, { "type": "GeneCombination", "id": "1058" }, { "type": "GeneCombination", "id": "1062" }, { "type": "GeneCombination", "id": "1093" }, { "type": "GeneCombination", "id": "1099" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CCDC141/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CCDC141/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CCDC141/?format=api" } }, { "type": "Gene", "id": "TCF12", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription activator activity, RNA polymerase II-specific', 'transcription cis-regulatory region binding', 'E-box binding', 'cAMP response element binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific double-stranded DNA binding', 'SMAD binding', 'protein heterodimerization activity', 'protein binding', 'HMG box domain binding', 'DNA-binding transcription factor binding', 'cis-regulatory region sequence-specific DNA binding', 'bHLH transcription factor binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [ "R-HSA-1266738", "R-HSA-162582", "R-HSA-166520", "R-HSA-187037", "R-HSA-198725", "R-HSA-212436", "R-HSA-525793", "R-HSA-73857", "R-HSA-74160", "R-HSA-8878171", "R-HSA-8939236", "R-HSA-9006934", "R-HSA-9031628" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q99081", "ensembl_id": "None", "entrez_id": "ENSG00000140262", "chromosome_number": "15", "lastmodified": "2023-05-16T12:02:33.110635" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2903" }, { "type": "SmallVariant", "id": "2914" }, { "type": "SmallVariant", "id": "2920" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TCF12/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TCF12/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "962" }, { "type": "GeneCombination", "id": "967" }, { "type": "GeneCombination", "id": "969" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TCF12/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TCF12/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TCF12/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }