Combination List
This API endpoint handles listing (/combinations) and retrieval (/combinations/{combination_pk}/) of oligogenic combinations from the database
GET /api/genecombinations/101/combinations/?format=api
{ "data": [ { "type": "Combination", "id": "OLI135", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 1, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 2, "functional_final_metascore": 2, "final_manual": 1, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Monogenic+Modifier", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:39.679520" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI135/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI135/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "281" }, { "type": "SmallVariant", "id": "282" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI135/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI135/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "624" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI135/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI135/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI135/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI135/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI135/?format=api" } }, { "type": "Combination", "id": "OLI136", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 1, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 2, "final_manual": 0, "final_metascore": 1 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:39.699983" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI136/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI136/diseases/?format=api" } }, "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "281" }, { "type": "SmallVariant", "id": "282" }, { "type": "SmallVariant", "id": "283" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI136/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI136/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "624" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI136/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI136/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI136/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI136/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI136/?format=api" } }, { "type": "Combination", "id": "OLI192", "attributes": { "scores": { "familial_evidence": 2, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 1, "functional_variant_evidence_metascore": 1, "functional_final_manual": 0, "functional_final_metascore": 2, "final_manual": 0, "final_metascore": 2 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.633123" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI192/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI192/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "375" }, { "type": "SmallVariant", "id": "376" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI192/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI192/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "651" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI192/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI192/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI192/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI192/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI192/?format=api" } }, { "type": "Combination", "id": "OLI193", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 0, "functional_variant_evidence_metascore": 0, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.648879" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI193/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI193/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "376" }, { "type": "SmallVariant", "id": "377" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI193/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI193/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "651" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI193/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI193/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI193/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI193/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI193/?format=api" } }, { "type": "Combination", "id": "OLI194", "attributes": { "scores": { "familial_evidence": 2, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 1, "statistical_evidence_metascore": 1, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 0, "functional_variant_evidence_metascore": 0, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:40.664368" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI194/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI194/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "377" }, { "type": "SmallVariant", "id": "378" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI194/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI194/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "651" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI194/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI194/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI194/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI194/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI194/?format=api" } }, { "type": "Combination", "id": "OLI252", "attributes": { "scores": { "familial_evidence": 1, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 2, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 0, "functional_variant_evidence_metascore": 0, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "East Asian", "lastmodified": "2021-11-16T17:59:41.634392" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI252/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI252/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "377" }, { "type": "SmallVariant", "id": "490" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI252/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI252/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "646" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI252/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI252/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI252/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI252/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI252/?format=api" } }, { "type": "Combination", "id": "OLI406", "attributes": { "scores": { "familial_evidence": 0, "statistical_evidence_manual": 0, "statistical_evidence_knowledge": 0, "statistical_evidence_metascore": 0, "functional_gene_evidence_manual": 0, "functional_gene_evidence_manual_harmonized": 2, "functional_gene_evidence_knowledge": 0, "functional_gene_evidence_metascore": 2, "functional_variant_evidence_manual": 0, "functional_variant_evidence_knowledge": 0, "functional_variant_evidence_metascore": 0, "functional_final_manual": 0, "functional_final_metascore": 0, "final_manual": 0, "final_metascore": 0 }, "omim_id": [], "oligogenic_effect": "Unknown", "status": "CU", "effect_predicted": false, "ethnicity": "Iranian", "lastmodified": "2021-11-16T17:59:44.895861" }, "relationships": { "diseases": { "meta": { "count": 1 }, "data": [ { "type": "Disease", "id": "87884" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI406/relationships/diseases?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI406/diseases/?format=api" } }, "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "874" }, { "type": "SmallVariant", "id": "875" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI406/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI406/variants/?format=api" } }, "reference_set": { "meta": { "count": 1 }, "data": [ { "type": "Reference", "id": "771" } ], "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI406/relationships/reference_set?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI406/references/?format=api" } }, "gene_combination": { "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI406/relationships/gene_combination?format=api", "related": "https://olida.ibsquare.be/api/combinations/OLI406/genecombinations/?format=api" }, "data": { "type": "GeneCombination", "id": "101" } } }, "links": { "self": "https://olida.ibsquare.be/api/combinations/OLI406/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 7 } }