Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/643/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CHD7", "attributes": { "go_molecular_function": [ "['chromatin binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'protein binding', 'ATP hydrolysis activity', 'DNA helicase activity', 'promoter-specific chromatin binding', 'ATP binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9P2D1", "ensembl_id": "None", "entrez_id": "ENSG00000171316", "chromosome_number": "8", "lastmodified": "2021-10-18T11:00:44.704701" }, "relationships": { "variant_set": { "meta": { "count": 70 }, "data": [ { "type": "SmallVariant", "id": "39" }, { "type": "SmallVariant", "id": "275" }, { "type": "SmallVariant", "id": "708" }, { "type": "SmallVariant", "id": "771" }, { "type": "SmallVariant", "id": "772" }, { "type": "SmallVariant", "id": "974" }, { "type": "SmallVariant", "id": "1158" }, { "type": "SmallVariant", "id": "1215" }, { "type": "SmallVariant", "id": "1495" }, { "type": "SmallVariant", "id": "1830" }, { "type": "SmallVariant", "id": "1853" }, { "type": "SmallVariant", "id": "1860" }, { "type": "SmallVariant", "id": "1882" }, { "type": "SmallVariant", "id": "1899" }, { "type": "SmallVariant", "id": "1905" }, { "type": "SmallVariant", "id": "1911" }, { "type": "SmallVariant", "id": "1912" }, { "type": "SmallVariant", "id": "1954" }, { "type": "SmallVariant", "id": "1968" }, { "type": "SmallVariant", "id": "2078" }, { "type": "SmallVariant", "id": "2401" }, { "type": "SmallVariant", "id": "2403" }, { "type": "SmallVariant", "id": "2494" }, { "type": "SmallVariant", "id": "2496" }, { "type": "SmallVariant", "id": "2500" }, { "type": "SmallVariant", "id": "2509" }, { "type": "SmallVariant", "id": "2518" }, { "type": "SmallVariant", "id": "2659" }, { "type": "SmallVariant", "id": "2661" }, { "type": "SmallVariant", "id": "2668" }, { "type": "SmallVariant", "id": "2674" }, { "type": "SmallVariant", "id": "2679" }, { "type": "SmallVariant", "id": "2702" }, { "type": "SmallVariant", "id": "2704" }, { "type": "SmallVariant", "id": "2706" }, { "type": "SmallVariant", "id": "2716" }, { "type": "SmallVariant", "id": "2720" }, { "type": "SmallVariant", "id": "2772" }, { "type": "SmallVariant", "id": "2818" }, { "type": "SmallVariant", "id": "2822" }, { "type": "SmallVariant", "id": "2823" }, { "type": "SmallVariant", "id": "2828" }, { "type": "SmallVariant", "id": "2837" }, { "type": "SmallVariant", "id": "2838" }, { "type": "SmallVariant", "id": "2841" }, { "type": "SmallVariant", "id": "2887" }, { "type": "SmallVariant", "id": "2932" }, { "type": "SmallVariant", "id": "2941" }, { "type": "SmallVariant", "id": "2945" }, { "type": "SmallVariant", "id": "2951" }, { "type": "SmallVariant", "id": "2952" }, { "type": "SmallVariant", "id": "2973" }, { "type": "SmallVariant", "id": "2986" }, { "type": "SmallVariant", "id": "3001" }, { "type": "SmallVariant", "id": "3005" }, { "type": "SmallVariant", "id": "3197" }, { "type": "SmallVariant", "id": "3223" }, { "type": "SmallVariant", "id": "3264" }, { "type": "SmallVariant", "id": "3321" }, { "type": "SmallVariant", "id": "3358" }, { "type": "SmallVariant", "id": "3359" }, { "type": "SmallVariant", "id": "3363" }, { "type": "SmallVariant", "id": "3376" }, { "type": "SmallVariant", "id": "3381" }, { "type": "SmallVariant", "id": "3384" }, { "type": "SmallVariant", "id": "3386" }, { "type": "SmallVariant", "id": "3472" }, { "type": "SmallVariant", "id": "3473" }, { "type": "SmallVariant", "id": "3475" }, { "type": "SmallVariant", "id": "3703" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHD7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 52 }, "data": [ { "type": "GeneCombination", "id": "16" }, { "type": "GeneCombination", "id": "98" }, { "type": "GeneCombination", "id": "227" }, { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "371" }, { "type": "GeneCombination", "id": "387" }, { "type": "GeneCombination", "id": "478" }, { "type": "GeneCombination", "id": "618" }, { "type": "GeneCombination", "id": "627" }, { "type": "GeneCombination", "id": "634" }, { "type": "GeneCombination", "id": "636" }, { "type": "GeneCombination", "id": "639" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "661" }, { "type": "GeneCombination", "id": "666" }, { "type": "GeneCombination", "id": "675" }, { "type": "GeneCombination", "id": "891" }, { "type": "GeneCombination", "id": "718" }, { "type": "GeneCombination", "id": "819" }, { "type": "GeneCombination", "id": "845" }, { "type": "GeneCombination", "id": "847" }, { "type": "GeneCombination", "id": "818" }, { "type": "GeneCombination", "id": "885" }, { "type": "GeneCombination", "id": "606" }, { "type": "GeneCombination", "id": "888" }, { "type": "GeneCombination", "id": "892" }, { "type": "GeneCombination", "id": "899" }, { "type": "GeneCombination", "id": "312" }, { "type": "GeneCombination", "id": "846" }, { "type": "GeneCombination", "id": "939" }, { "type": "GeneCombination", "id": "941" }, { "type": "GeneCombination", "id": "944" }, { "type": "GeneCombination", "id": "945" }, { "type": "GeneCombination", "id": "949" }, { "type": "GeneCombination", "id": "956" }, { "type": "GeneCombination", "id": "974" }, { "type": "GeneCombination", "id": "978" }, { "type": "GeneCombination", "id": "980" }, { "type": "GeneCombination", "id": "982" }, { "type": "GeneCombination", "id": "990" }, { "type": "GeneCombination", "id": "1002" }, { "type": "GeneCombination", "id": "1003" }, { "type": "GeneCombination", "id": "1078" }, { "type": "GeneCombination", "id": "1080" }, { "type": "GeneCombination", "id": "1088" }, { "type": "GeneCombination", "id": "1097" }, { "type": "GeneCombination", "id": "1117" }, { "type": "GeneCombination", "id": "850" }, { "type": "GeneCombination", "id": "1165" }, { "type": "GeneCombination", "id": "1166" }, { "type": "GeneCombination", "id": "1167" }, { "type": "GeneCombination", "id": "1253" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CHD7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CHD7/?format=api" } }, { "type": "Gene", "id": "MTOR", "attributes": { "go_molecular_function": [ "['protein kinase activity', 'RNA polymerase III type 1 promoter sequence-specific DNA binding', 'identical protein binding', 'protein serine/threonine kinase activity', 'TFIIIC-class transcription factor complex binding', 'ATP binding', 'protein serine kinase activity', 'phosphoprotein binding', 'kinase activity', 'RNA polymerase III type 2 promoter sequence-specific DNA binding', 'protein binding', 'ribosome binding', 'RNA polymerase III type 3 promoter sequence-specific DNA binding', 'protein serine/threonine/tyrosine kinase activity']" ], "pathway_id": [ "kegg_path:hsa01521", "kegg_path:hsa01522", "kegg_path:hsa04012", "kegg_path:hsa04066", "kegg_path:hsa04072", "kegg_path:hsa04136", "kegg_path:hsa04140", "kegg_path:hsa04150", "kegg_path:hsa04151", "kegg_path:hsa04152", "kegg_path:hsa04211", "kegg_path:hsa04213", "kegg_path:hsa04218", "kegg_path:hsa04371", "kegg_path:hsa04613", "kegg_path:hsa04630", "kegg_path:hsa04659", "kegg_path:hsa04714", "kegg_path:hsa04910", "kegg_path:hsa04919", "kegg_path:hsa04920", "kegg_path:hsa04930", "kegg_path:hsa04931", "kegg_path:hsa04935", "kegg_path:hsa05010", "kegg_path:hsa05014", "kegg_path:hsa05016", "kegg_path:hsa05017", "kegg_path:hsa05022", "kegg_path:hsa05131", "kegg_path:hsa05163", "kegg_path:hsa05165", "kegg_path:hsa05167", "kegg_path:hsa05168", "kegg_path:hsa05170", "kegg_path:hsa05200", "kegg_path:hsa05205", "kegg_path:hsa05206", "kegg_path:hsa05210", "kegg_path:hsa05212", "kegg_path:hsa05214", "kegg_path:hsa05215", "kegg_path:hsa05221", "kegg_path:hsa05224", "kegg_path:hsa05225", "kegg_path:hsa05226", "kegg_path:hsa05230", "kegg_path:hsa05231", "kegg_path:hsa05235", "R-HSA-1257604", "R-HSA-1280218", "R-HSA-162582", "R-HSA-1632852", "R-HSA-1643685", "R-HSA-165159", "R-HSA-166208", "R-HSA-168256", "R-HSA-194138", "R-HSA-212436", "R-HSA-2219528", "R-HSA-2262752", "R-HSA-3371556", "R-HSA-3371571", "R-HSA-3700989", "R-HSA-380972", "R-HSA-388841", "R-HSA-389356", "R-HSA-389357", "R-HSA-4420097", "R-HSA-5218920", "R-HSA-5628897", "R-HSA-5633007", "R-HSA-5663202", "R-HSA-5674400", "R-HSA-6804757", "R-HSA-6806003", "R-HSA-6807070", "R-HSA-73857", "R-HSA-74160", "R-HSA-8943724", "R-HSA-8953897", "R-HSA-9006925", "R-HSA-9006934", "R-HSA-9612973", "R-HSA-9639288" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P42345", "ensembl_id": "None", "entrez_id": "ENSG00000198793", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.474959" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "1881" }, { "type": "SmallVariant", "id": "1913" }, { "type": "SmallVariant", "id": "1959" }, { "type": "SmallVariant", "id": "2621" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTOR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 4 }, "data": [ { "type": "GeneCombination", "id": "626" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "871" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MTOR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MTOR/?format=api" } }, { "type": "Gene", "id": "RELN", "attributes": { "go_molecular_function": [ "['lipoprotein particle receptor binding', 'serine-type peptidase activity', 'very-low-density lipoprotein particle receptor binding', 'metal ion binding']" ], "pathway_id": [ "kegg_path:hsa04151", "kegg_path:hsa04510", "kegg_path:hsa04512", "kegg_path:hsa05017", "kegg_path:hsa05165", "R-HSA-1266738", "R-HSA-422475", "R-HSA-8866376", "R-HSA-9675108" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P78509", "ensembl_id": "None", "entrez_id": "ENSG00000189056", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.519444" }, "relationships": { "variant_set": { "meta": { "count": 24 }, "data": [ { "type": "SmallVariant", "id": "1852" }, { "type": "SmallVariant", "id": "1871" }, { "type": "SmallVariant", "id": "1891" }, { "type": "SmallVariant", "id": "1906" }, { "type": "SmallVariant", "id": "1930" }, { "type": "SmallVariant", "id": "1934" }, { "type": "SmallVariant", "id": "1936" }, { "type": "SmallVariant", "id": "1970" }, { "type": "SmallVariant", "id": "2332" }, { "type": "SmallVariant", "id": "2343" }, { "type": "SmallVariant", "id": "3063" }, { "type": "SmallVariant", "id": "3064" }, { "type": "SmallVariant", "id": "3069" }, { "type": "SmallVariant", "id": "3070" }, { "type": "SmallVariant", "id": "3072" }, { "type": "SmallVariant", "id": "3073" }, { "type": "SmallVariant", "id": "3075" }, { "type": "SmallVariant", "id": "3076" }, { "type": "SmallVariant", "id": "3079" }, { "type": "SmallVariant", "id": "3085" }, { "type": "SmallVariant", "id": "3088" }, { "type": "SmallVariant", "id": "3089" }, { "type": "SmallVariant", "id": "3092" }, { "type": "SmallVariant", "id": "3093" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RELN/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 25 }, "data": [ { "type": "GeneCombination", "id": "644" }, { "type": "GeneCombination", "id": "615" }, { "type": "GeneCombination", "id": "621" }, { "type": "GeneCombination", "id": "630" }, { "type": "GeneCombination", "id": "639" }, { "type": "GeneCombination", "id": "642" }, { "type": "GeneCombination", "id": "643" }, { "type": "GeneCombination", "id": "652" }, { "type": "GeneCombination", "id": "653" }, { "type": "GeneCombination", "id": "654" }, { "type": "GeneCombination", "id": "663" }, { "type": "GeneCombination", "id": "664" }, { "type": "GeneCombination", "id": "668" }, { "type": "GeneCombination", "id": "670" }, { "type": "GeneCombination", "id": "676" }, { "type": "GeneCombination", "id": "785" }, { "type": "GeneCombination", "id": "791" }, { "type": "GeneCombination", "id": "1030" }, { "type": "GeneCombination", "id": "1031" }, { "type": "GeneCombination", "id": "1032" }, { "type": "GeneCombination", "id": "1033" }, { "type": "GeneCombination", "id": "1035" }, { "type": "GeneCombination", "id": "1036" }, { "type": "GeneCombination", "id": "1037" }, { "type": "GeneCombination", "id": "1028" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RELN/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RELN/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }