Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/454/genes/?format=api
{ "data": [ { "type": "Gene", "id": "MAPT", "attributes": { "go_molecular_function": [ "['enzyme binding', 'single-stranded DNA binding', 'histone-dependent DNA binding', 'double-stranded DNA binding', 'sequence-specific DNA binding', 'minor groove of adenine-thymine-rich DNA binding', 'SH3 domain binding', 'Hsp90 protein binding', 'protein kinase binding', 'lipoprotein particle binding', 'RNA binding', 'dynactin binding', 'protein phosphatase 2A binding', 'identical protein binding', 'microtubule binding', 'phosphatidylinositol binding', 'chaperone binding', 'phosphatidylinositol bisphosphate binding', 'DNA binding', 'protein-macromolecule adaptor activity', 'apolipoprotein binding', 'protein binding', 'microtubule lateral binding', 'actin binding']" ], "pathway_id": [ "kegg_path:hsa04010", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05022", "kegg_path:hsa04010", "kegg_path:hsa05010", "kegg_path:hsa05012", "kegg_path:hsa05022", "R-HSA-109581", "R-HSA-111465", "R-HSA-264870", "R-HSA-5357801", "R-HSA-75153" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P10636", "ensembl_id": "None", "entrez_id": "ENSG00000186868", "chromosome_number": "17", "lastmodified": "2021-10-18T11:00:44.827622" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1435" }, { "type": "SmallVariant", "id": "1441" }, { "type": "SmallVariant", "id": "3098" }, { "type": "SmallVariant", "id": "3423" }, { "type": "SmallVariant", "id": "3438" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAPT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAPT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "457" }, { "type": "GeneCombination", "id": "1038" }, { "type": "GeneCombination", "id": "1039" }, { "type": "GeneCombination", "id": "1149" }, { "type": "GeneCombination", "id": "1153" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAPT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAPT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAPT/?format=api" } }, { "type": "Gene", "id": "MATR3", "attributes": { "go_molecular_function": [ "['zinc ion binding', 'protein binding', 'RNA binding', 'structural molecule activity', 'miRNA binding', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa05014", "kegg_path:hsa05014" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P43243", "ensembl_id": "None", "entrez_id": "ENSG00000015479", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.276575" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1429" }, { "type": "SmallVariant", "id": "1434" }, { "type": "SmallVariant", "id": "3441" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MATR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MATR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "451" }, { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "1155" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MATR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MATR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MATR3/?format=api" } }, { "type": "Gene", "id": "SETX", "attributes": { "go_molecular_function": [ "['DNA binding', 'hydrolase activity', 'protein binding', 'RNA binding', 'DNA helicase activity', 'transcription termination site sequence-specific DNA binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa05014" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q7Z333", "ensembl_id": "None", "entrez_id": "ENSG00000107290", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.749548" }, "relationships": { "variant_set": { "meta": { "count": 23 }, "data": [ { "type": "SmallVariant", "id": "528" }, { "type": "SmallVariant", "id": "538" }, { "type": "SmallVariant", "id": "544" }, { "type": "SmallVariant", "id": "546" }, { "type": "SmallVariant", "id": "547" }, { "type": "SmallVariant", "id": "921" }, { "type": "SmallVariant", "id": "929" }, { "type": "SmallVariant", "id": "1381" }, { "type": "SmallVariant", "id": "1425" }, { "type": "SmallVariant", "id": "1431" }, { "type": "SmallVariant", "id": "1439" }, { "type": "SmallVariant", "id": "1726" }, { "type": "SmallVariant", "id": "1727" }, { "type": "SmallVariant", "id": "2041" }, { "type": "SmallVariant", "id": "2044" }, { "type": "SmallVariant", "id": "2054" }, { "type": "SmallVariant", "id": "2099" }, { "type": "SmallVariant", "id": "2100" }, { "type": "SmallVariant", "id": "2637" }, { "type": "SmallVariant", "id": "3435" }, { "type": "SmallVariant", "id": "3443" }, { "type": "SmallVariant", "id": "3608" }, { "type": "SmallVariant", "id": "3609" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "177" }, { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "181" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "186" }, { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "290" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "456" }, { "type": "GeneCombination", "id": "458" }, { "type": "GeneCombination", "id": "568" }, { "type": "GeneCombination", "id": "703" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1156" }, { "type": "GeneCombination", "id": "1213" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }