Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/579/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ABCA7", "attributes": { "go_molecular_function": [ "apolipoprotein A-I receptor activity", "phosphatidylserine floppase activity", "phosphatidylcholine floppase activity" ], "pathway_id": [ "kegg_path:hsa02010", "R-HSA-1369062", "R-HSA-382556", "R-HSA-382551" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q8IZY2", "ensembl_id": "ENSG00000064687", "entrez_id": "10347", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.582549" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "1729" }, { "type": "SmallVariant", "id": "1757" }, { "type": "SmallVariant", "id": "1758" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ABCA7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ABCA7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "569" }, { "type": "GeneCombination", "id": "579" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ABCA7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ABCA7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ABCA7/?format=api" } }, { "type": "Gene", "id": "SPEG", "attributes": { "go_molecular_function": [ "protein binding", "transferase activity", "kinase activity", "protein serine/threonine kinase activity", "ATP binding", "nucleotide binding", "protein kinase activity", "protein serine kinase activity" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q15772", "ensembl_id": "ENSG00000072195", "entrez_id": "10290", "chromosome_number": "2", "lastmodified": "2021-10-18T11:00:44.447973" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1741" }, { "type": "SmallVariant", "id": "1755" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SPEG/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SPEG/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "574" }, { "type": "GeneCombination", "id": "579" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SPEG/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SPEG/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SPEG/?format=api" } }, { "type": "Gene", "id": "TPM2", "attributes": { "go_molecular_function": [ "actin binding", "actin filament binding", "protein heterodimerization activity", "protein homodimerization activity", "structural constituent of muscle", "identical protein binding" ], "pathway_id": [ "kegg_path:hsa05410", "kegg_path:hsa04260", "R-HSA-397014", "R-HSA-390522", "R-HSA-445355", "kegg_path:hsa04261", "kegg_path:hsa05414" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P07951", "ensembl_id": "ENSG00000198467", "entrez_id": "7169", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.430078" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1756" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TPM2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TPM2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "579" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/TPM2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/TPM2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/TPM2/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }