Gene Combination Instance – Django REST framework

This API endpoint handles listing (/references) and retrieval (/references/<ID>/) of References from the database
that support the inclusion of at least one oligogenic combination in OLIDA.

GET /api/genecombinations/1246/?format=api

HTTP 200 OK
Allow: GET, HEAD, OPTIONS
Content-Type: application/vnd.api+json
Vary: Accept

{
    "data": {
        "type": "GeneCombination",
        "id": "1246",
        "attributes": {
            "gene_relationship": [
                "Involved in the same disease",
                "Indirectly interacting",
                "Same protein complex"
            ],
            "protein_interactions": [
                "(RPL27, RPS19)"
            ],
            "common_pathways": [
                "Eukaryotic Translation Termination",
                "Influenza Viral RNA Transcription and Replication",
                "Nonsense-Mediated Decay (NMD)",
                "rRNA processing",
                "Viral mRNA Translation",
                "Cellular responses to stress",
                "Metabolism of RNA",
                "Major pathway of rRNA processing in the nucleolus and cytosol",
                "Signaling by ROBO receptors",
                "Infectious disease",
                "Regulation of expression of SLITs and ROBOs",
                "Coronavirus disease - COVID-19",
                "Formation of a pool of free 40S subunits",
                "Peptide chain elongation",
                "Selenoamino acid metabolism",
                "Metabolism of proteins",
                "Eukaryotic Translation Initiation",
                "Response of EIF2AK4 (GCN2) to amino acid deficiency",
                "Developmental Biology",
                "Disease",
                "Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)",
                "Eukaryotic Translation Elongation",
                "Metabolism",
                "Nervous system development",
                "Metabolism of amino acids and derivatives",
                "Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)",
                "Influenza Infection",
                "L13a-mediated translational silencing of Ceruloplasmin expression",
                "Axon guidance",
                "GTP hydrolysis and joining of the 60S ribosomal subunit",
                "Translation",
                "Selenocysteine synthesis",
                "SRP-dependent cotranslational protein targeting to membrane",
                "Cap-dependent Translation Initiation",
                "Cellular responses to external stimuli",
                "Ribosome",
                "rRNA processing in the nucleus and cytosol"
            ],
            "genecomb_metascore": 2,
            "lastmodified": "2024-02-29T15:02:23.302105"
        },
        "relationships": {
            "combination_set": {
                "meta": {
                    "count": 1
                },
                "data": [
                    {
                        "type": "Combination",
                        "id": "OLI1739"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/1246/relationships/combination_set?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/1246/combinations/?format=api"
                }
            },
            "genes": {
                "meta": {
                    "count": 2
                },
                "data": [
                    {
                        "type": "Gene",
                        "id": "RPL27"
                    },
                    {
                        "type": "Gene",
                        "id": "RPS19"
                    }
                ],
                "links": {
                    "self": "https://olida.ibsquare.be/api/genecombinations/1246/relationships/genes?format=api",
                    "related": "https://olida.ibsquare.be/api/genecombinations/1246/genes/?format=api"
                }
            }
        },
        "links": {
            "self": "https://olida.ibsquare.be/api/genecombinations/1246/?format=api"
        }
    }
}