Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1085/genes/?format=api
{ "data": [ { "type": "Gene", "id": "GHR", "attributes": { "go_molecular_function": [ "['peptide hormone binding', 'proline-rich region binding', 'SH2 domain binding', 'growth hormone receptor activity', 'protein kinase binding', 'cytokine binding', 'protein phosphatase binding', 'protein binding', 'growth factor binding', 'protein homodimerization activity', 'cytokine receptor activity', 'identical protein binding']" ], "pathway_id": [ "kegg_path:hsa04060", "kegg_path:hsa04080", "kegg_path:hsa04151", "kegg_path:hsa04630", "kegg_path:hsa04935", "R-HSA-1170546", "R-HSA-1280215", "R-HSA-168256", "R-HSA-982772" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P10912", "ensembl_id": "None", "entrez_id": "ENSG00000112964", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.556257" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "1957" }, { "type": "SmallVariant", "id": "1967" }, { "type": "SmallVariant", "id": "3219" }, { "type": "SmallVariant", "id": "3222" }, { "type": "SmallVariant", "id": "3232" }, { "type": "SmallVariant", "id": "3249" }, { "type": "SmallVariant", "id": "3269" }, { "type": "SmallVariant", "id": "3279" }, { "type": "SmallVariant", "id": "3330" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 10 }, "data": [ { "type": "GeneCombination", "id": "669" }, { "type": "GeneCombination", "id": "674" }, { "type": "GeneCombination", "id": "1076" }, { "type": "GeneCombination", "id": "1077" }, { "type": "GeneCombination", "id": "1082" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1089" }, { "type": "GeneCombination", "id": "1099" }, { "type": "GeneCombination", "id": "1103" }, { "type": "GeneCombination", "id": "1123" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GHR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GHR/?format=api" } }, { "type": "Gene", "id": "GPRC6A", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity']" ], "pathway_id": [ "kegg_path:hsa04621", "R-HSA-162582", "R-HSA-372790", "R-HSA-388396", "R-HSA-416476", "R-HSA-420499", "R-HSA-500792" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q5T6X5", "ensembl_id": "None", "entrez_id": "ENSG00000173612", "chromosome_number": "6", "lastmodified": "2023-05-16T12:02:33.486621" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "3157" }, { "type": "SmallVariant", "id": "3183" }, { "type": "SmallVariant", "id": "3186" }, { "type": "SmallVariant", "id": "3202" }, { "type": "SmallVariant", "id": "3204" }, { "type": "SmallVariant", "id": "3239" }, { "type": "SmallVariant", "id": "3312" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "1053" }, { "type": "GeneCombination", "id": "1063" }, { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1069" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1102" }, { "type": "GeneCombination", "id": "1105" }, { "type": "GeneCombination", "id": "1107" }, { "type": "GeneCombination", "id": "1111" }, { "type": "GeneCombination", "id": "1114" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/GPRC6A/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/GPRC6A/?format=api" } }, { "type": "Gene", "id": "HSD17B3", "attributes": { "go_molecular_function": [ "['17-beta-hydroxysteroid dehydrogenase (NADP+) activity', 'oxidoreductase activity', 'testosterone dehydrogenase [NAD(P)] activity', 'testosterone 17-beta-dehydrogenase (NADP+) activity']" ], "pathway_id": [ "kegg_path:hsa00140", "kegg_path:hsa01100", "R-HSA-1430728", "R-HSA-193048", "R-HSA-196071", "R-HSA-556833", "R-HSA-75105", "R-HSA-75876", "R-HSA-8957322", "R-HSA-8978868", "kegg_path:hsa00140", "kegg_path:hsa01100" ], "essential_gene": null, "status": "CU", "uniprot_acc": "P37058", "ensembl_id": "None", "entrez_id": "ENSG00000130948", "chromosome_number": "9", "lastmodified": "2023-05-16T12:02:33.563033" }, "relationships": { "variant_set": { "meta": { "count": 4 }, "data": [ { "type": "SmallVariant", "id": "3185" }, { "type": "SmallVariant", "id": "3215" }, { "type": "SmallVariant", "id": "3237" }, { "type": "SmallVariant", "id": "3283" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "1064" }, { "type": "GeneCombination", "id": "1066" }, { "type": "GeneCombination", "id": "1075" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1106" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/HSD17B3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/HSD17B3/?format=api" } }, { "type": "Gene", "id": "RNF216", "attributes": { "go_molecular_function": [ "['ubiquitin protein ligase activity', 'protein binding', 'metal ion binding']" ], "pathway_id": [ "R-HSA-168249", "R-HSA-168256", "R-HSA-168928", "R-HSA-936440" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9NWF9", "ensembl_id": "None", "entrez_id": "ENSG00000011275", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.917313" }, "relationships": { "variant_set": { "meta": { "count": 9 }, "data": [ { "type": "SmallVariant", "id": "36" }, { "type": "SmallVariant", "id": "586" }, { "type": "SmallVariant", "id": "773" }, { "type": "SmallVariant", "id": "1799" }, { "type": "SmallVariant", "id": "2933" }, { "type": "SmallVariant", "id": "2978" }, { "type": "SmallVariant", "id": "3198" }, { "type": "SmallVariant", "id": "3238" }, { "type": "SmallVariant", "id": "3246" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNF216/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 9 }, "data": [ { "type": "GeneCombination", "id": "14" }, { "type": "GeneCombination", "id": "203" }, { "type": "GeneCombination", "id": "242" }, { "type": "GeneCombination", "id": "596" }, { "type": "GeneCombination", "id": "974" }, { "type": "GeneCombination", "id": "993" }, { "type": "GeneCombination", "id": "1068" }, { "type": "GeneCombination", "id": "1085" }, { "type": "GeneCombination", "id": "1087" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RNF216/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RNF216/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }