Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/124/genes/?format=api
{ "data": [ { "type": "Gene", "id": "NKX2-1", "attributes": { "go_molecular_function": [ "['RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'enzyme binding', 'transcription cis-regulatory region binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'intronic transcription regulatory region sequence-specific DNA binding', 'DNA binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein binding', 'RNA polymerase II transcription regulatory region sequence-specific DNA binding', 'DNA-binding transcription factor activity']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P43699", "ensembl_id": "None", "entrez_id": "ENSG00000136352", "chromosome_number": "14", "lastmodified": "2021-10-18T11:00:44.402904" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "1227" }, { "type": "SmallVariant", "id": "1231" }, { "type": "SmallVariant", "id": "1249" }, { "type": "SmallVariant", "id": "359" }, { "type": "SmallVariant", "id": "2358" }, { "type": "SmallVariant", "id": "2364" }, { "type": "SmallVariant", "id": "3148" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NKX2-1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NKX2-1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "124" }, { "type": "GeneCombination", "id": "391" }, { "type": "GeneCombination", "id": "393" }, { "type": "GeneCombination", "id": "398" }, { "type": "GeneCombination", "id": "798" }, { "type": "GeneCombination", "id": "799" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NKX2-1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NKX2-1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NKX2-1/?format=api" } }, { "type": "Gene", "id": "RET", "attributes": { "go_molecular_function": [ "protein binding", "transmembrane receptor protein tyrosine kinase activity" ], "pathway_id": [ "kegg_path:hsa05230", "R-HSA-5673001", "R-HSA-162582", "R-HSA-8853659", "kegg_path:hsa04020", "kegg_path:hsa05223", "R-HSA-5684996", "kegg_path:hsa05216", "kegg_path:hsa05223", "kegg_path:hsa05216", "R-HSA-1266738", "kegg_path:hsa04020", "R-HSA-422475", "R-HSA-5683057", "R-HSA-9675108", "kegg_path:hsa05230", "kegg_path:hsa05200", "kegg_path:hsa05200" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P07949", "ensembl_id": "ENSG00000165731", "entrez_id": "5979", "chromosome_number": "10", "lastmodified": "2021-10-18T11:00:44.700530" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "42" }, { "type": "SmallVariant", "id": "75" }, { "type": "SmallVariant", "id": "360" }, { "type": "SmallVariant", "id": "718" }, { "type": "SmallVariant", "id": "734" }, { "type": "SmallVariant", "id": "1273" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RET/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RET/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "17" }, { "type": "GeneCombination", "id": "30" }, { "type": "GeneCombination", "id": "124" }, { "type": "GeneCombination", "id": "231" }, { "type": "GeneCombination", "id": "235" }, { "type": "GeneCombination", "id": "405" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/RET/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/RET/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/RET/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }