Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/226/genes/?format=api
{ "data": [ { "type": "Gene", "id": "FUZ", "attributes": { "go_molecular_function": [ "protein binding" ], "pathway_id": [ "R-HSA-5358351", "R-HSA-162582", "R-HSA-5610787" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9BT04", "ensembl_id": "ENSG00000010361", "entrez_id": "80199", "chromosome_number": "19", "lastmodified": "2021-10-18T11:00:44.309933" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "705" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUZ/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUZ/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "226" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FUZ/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FUZ/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FUZ/?format=api" } }, { "type": "Gene", "id": "MAP3K7", "attributes": { "go_molecular_function": [ "MAP kinase kinase kinase activity", "protein binding", "ATP binding", "magnesium ion binding", "protein kinase activity", "identical protein binding" ], "pathway_id": [ "R-HSA-168179", "R-HSA-1280215", "R-HSA-202424", "kegg_path:hsa04620", "kegg_path:hsa04660", "R-HSA-1169091", "R-HSA-75893", "R-HSA-1280218", "R-HSA-168138", "R-HSA-446652", "kegg_path:hsa04622", "R-HSA-5689880", "R-HSA-168181", "R-HSA-2871837", "R-HSA-450321", "R-HSA-9014325", "kegg_path:hsa05132", "R-HSA-168643", "R-HSA-168898", "kegg_path:hsa05131", "R-HSA-937042", "R-HSA-9645460", "kegg_path:hsa04152", "R-HSA-168638", "R-HSA-448424", "R-HSA-975163", "kegg_path:hsa05171", "R-HSA-168176", "R-HSA-162582", "R-HSA-166166", "R-HSA-168142", "kegg_path:hsa04010", "kegg_path:hsa05418", "kegg_path:hsa05135", "R-HSA-5688426", "kegg_path:hsa05170", "kegg_path:hsa05145", "kegg_path:hsa04668", "R-HSA-166016", "R-HSA-168164", "R-HSA-73887", "kegg_path:hsa04520", "kegg_path:hsa04064", "R-HSA-5607764", "R-HSA-975871", "R-HSA-392499", "kegg_path:hsa04140", "kegg_path:hsa04380", "R-HSA-1168372", "R-HSA-202403", "R-HSA-168256", "R-HSA-450302", "R-HSA-937072", "kegg_path:hsa05168", "R-HSA-166058", "R-HSA-445989", "kegg_path:hsa05162", "R-HSA-4086398", "R-HSA-3858494", "R-HSA-975138", "kegg_path:hsa05140", "R-HSA-449147", "R-HSA-597592", "kegg_path:hsa04310", "R-HSA-195721", "R-HSA-2454202", "kegg_path:hsa04613", "R-HSA-168188", "R-HSA-975155", "kegg_path:hsa05130", "kegg_path:hsa04621", "R-HSA-181438", "R-HSA-983705", "R-HSA-5357956", "R-HSA-937061", "R-HSA-450294", "R-HSA-9020702", "kegg_path:hsa05161", "kegg_path:hsa05169", "R-HSA-168249", "R-HSA-5621481", "kegg_path:hsa04657" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O43318", "ensembl_id": "ENSG00000135341", "entrez_id": "6885", "chromosome_number": "6", "lastmodified": "2021-10-18T11:00:44.502903" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "706" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAP3K7/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAP3K7/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "226" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/MAP3K7/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/MAP3K7/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/MAP3K7/?format=api" } }, { "type": "Gene", "id": "POR", "attributes": { "go_molecular_function": [ "['NADPH-hemoprotein reductase activity', 'nitric oxide dioxygenase activity', 'hydrolase activity', 'enzyme binding', 'oxidoreductase activity', 'NADP binding', 'flavin adenine dinucleotide binding', 'electron transfer activity', 'protein binding', 'cytochrome-b5 reductase activity, acting on NAD(P)H', 'iron-cytochrome-c reductase activity', 'FMN binding']" ], "pathway_id": [ "R-HSA-1430728", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945", "R-HSA-1430728", "R-HSA-211859", "R-HSA-211897", "R-HSA-211945" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P16435", "ensembl_id": "None", "entrez_id": "ENSG00000127948", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.656385" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "707" }, { "type": "SmallVariant", "id": "1205" }, { "type": "SmallVariant", "id": "2166" }, { "type": "SmallVariant", "id": "2178" }, { "type": "SmallVariant", "id": "3205" }, { "type": "SmallVariant", "id": "3315" }, { "type": "SmallVariant", "id": "3708" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POR/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POR/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 7 }, "data": [ { "type": "GeneCombination", "id": "226" }, { "type": "GeneCombination", "id": "385" }, { "type": "GeneCombination", "id": "737" }, { "type": "GeneCombination", "id": "742" }, { "type": "GeneCombination", "id": "1070" }, { "type": "GeneCombination", "id": "1115" }, { "type": "GeneCombination", "id": "1255" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/POR/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/POR/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/POR/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }