Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/548/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CBS", "attributes": { "go_molecular_function": [ "pyridoxal phosphate binding", "ubiquitin protein ligase binding", "protein binding", "cystathionine beta-synthase activity", "protein homodimerization activity", "modified amino acid binding", "heme binding", "enzyme binding" ], "pathway_id": [ "kegg_path:hsa00260", "R-HSA-1614603", "R-HSA-2408522", "kegg_path:hsa00270", "R-HSA-71291", "kegg_path:hsa01100", "R-HSA-2408508", "kegg_path:hsa01230", "R-HSA-1430728", "R-HSA-1614635" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35520", "ensembl_id": "ENSG00000160200", "entrez_id": "875", "chromosome_number": "21", "lastmodified": "2021-10-18T11:00:44.877437" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1683" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CBS/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CBS/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "548" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CBS/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CBS/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CBS/?format=api" } }, { "type": "Gene", "id": "ZIC3", "attributes": { "go_molecular_function": [ "RNA polymerase II transcription regulatory region sequence-specific DNA binding", "protein binding", "DNA-binding transcription activator activity, RNA polymerase II-specific", "RNA polymerase II cis-regulatory region sequence-specific DNA binding", "sequence-specific double-stranded DNA binding", "DNA-binding transcription factor activity" ], "pathway_id": [ "R-HSA-2892247", "R-HSA-452723", "R-HSA-1266738", "kegg_path:hsa04550" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "O60481", "ensembl_id": "ENSG00000156925", "entrez_id": "7547", "chromosome_number": "X", "lastmodified": "2021-10-18T11:00:44.879577" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZIC3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "110" }, { "type": "GeneCombination", "id": "112" }, { "type": "GeneCombination", "id": "485" }, { "type": "GeneCombination", "id": "502" }, { "type": "GeneCombination", "id": "511" }, { "type": "GeneCombination", "id": "548" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ZIC3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ZIC3/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 2 } }