Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/490/genes/?format=api
{ "data": [ { "type": "Gene", "id": "CAT", "attributes": { "go_molecular_function": [ "catalase activity", "identical protein binding" ], "pathway_id": [ "kegg_path:hsa00630", "R-HSA-168249", "R-HSA-9614085", "kegg_path:hsa04211", "kegg_path:hsa04068", "R-HSA-168256", "kegg_path:hsa01200", "R-HSA-9033241", "R-HSA-73857", "kegg_path:hsa04213", "R-HSA-9609507", "kegg_path:hsa00380", "R-HSA-212436", "R-HSA-6798695", "kegg_path:hsa01100", "R-HSA-9615017", "kegg_path:hsa05022", "R-HSA-74160", "R-HSA-2262752", "kegg_path:hsa04146", "kegg_path:hsa05014", "R-HSA-8953897", "R-HSA-3299685" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P04040", "ensembl_id": "ENSG00000121691", "entrez_id": "847", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.969770" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "1526" }, { "type": "SmallVariant", "id": "1646" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CAT/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CAT/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "534" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CAT/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CAT/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CAT/?format=api" } }, { "type": "Gene", "id": "CELSR2", "attributes": { "go_molecular_function": [ "G protein-coupled receptor activity", "transmembrane signaling receptor activity", "calcium ion binding" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HCU4", "ensembl_id": "ENSG00000143126", "entrez_id": "1952", "chromosome_number": "1", "lastmodified": "2021-10-18T11:00:44.972153" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "1519" }, { "type": "SmallVariant", "id": "1536" }, { "type": "SmallVariant", "id": "1617" }, { "type": "SmallVariant", "id": "1623" }, { "type": "SmallVariant", "id": "1650" }, { "type": "SmallVariant", "id": "1665" }, { "type": "SmallVariant", "id": "1691" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 11 }, "data": [ { "type": "GeneCombination", "id": "488" }, { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "493" }, { "type": "GeneCombination", "id": "509" }, { "type": "GeneCombination", "id": "520" }, { "type": "GeneCombination", "id": "523" }, { "type": "GeneCombination", "id": "525" }, { "type": "GeneCombination", "id": "535" }, { "type": "GeneCombination", "id": "536" }, { "type": "GeneCombination", "id": "542" }, { "type": "GeneCombination", "id": "551" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR2/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR2/?format=api" } }, { "type": "Gene", "id": "CELSR3", "attributes": { "go_molecular_function": [ "['G protein-coupled receptor activity', 'calcium ion binding', 'protein binding']" ], "pathway_id": [], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q9NYQ7", "ensembl_id": "None", "entrez_id": "ENSG00000008300", "chromosome_number": "3", "lastmodified": "2021-10-18T11:00:44.329047" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1528" }, { "type": "SmallVariant", "id": "1566" }, { "type": "SmallVariant", "id": "1611" }, { "type": "SmallVariant", "id": "1612" }, { "type": "SmallVariant", "id": "3115" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR3/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR3/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "503" }, { "type": "GeneCombination", "id": "518" }, { "type": "GeneCombination", "id": "526" }, { "type": "GeneCombination", "id": "1043" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR3/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/CELSR3/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/CELSR3/?format=api" } }, { "type": "Gene", "id": "DCHS1", "attributes": { "go_molecular_function": [ "cadherin binding", "calcium ion binding" ], "pathway_id": [ "kegg_path:hsa04392" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "Q96JQ0", "ensembl_id": "ENSG00000166341", "entrez_id": "8642", "chromosome_number": "11", "lastmodified": "2021-10-18T11:00:44.372944" }, "relationships": { "variant_set": { "meta": { "count": 5 }, "data": [ { "type": "SmallVariant", "id": "1501" }, { "type": "SmallVariant", "id": "1513" }, { "type": "SmallVariant", "id": "1527" }, { "type": "SmallVariant", "id": "1545" }, { "type": "SmallVariant", "id": "1634" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCHS1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCHS1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 5 }, "data": [ { "type": "GeneCombination", "id": "481" }, { "type": "GeneCombination", "id": "486" }, { "type": "GeneCombination", "id": "490" }, { "type": "GeneCombination", "id": "496" }, { "type": "GeneCombination", "id": "529" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/DCHS1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/DCHS1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/DCHS1/?format=api" } }, { "type": "Gene", "id": "SMURF1", "attributes": { "go_molecular_function": [ "phospholipid binding", "ubiquitin-protein transferase activity", "ubiquitin protein ligase activity", "protein binding" ], "pathway_id": [ "R-HSA-168256", "R-HSA-983168", "R-HSA-5358351", "kegg_path:hsa04350", "kegg_path:hsa04120", "R-HSA-1280218", "R-HSA-2173788", "kegg_path:hsa04144", "R-HSA-2173791", "R-HSA-5632684", "R-HSA-170834", "kegg_path:hsa04340", "R-HSA-201451", "R-HSA-73857", "R-HSA-8941858", "R-HSA-4086400", "R-HSA-983169", "R-HSA-8878159", "R-HSA-195721", "R-HSA-162582", "R-HSA-8939902", "R-HSA-2173789", "R-HSA-8878166", "R-HSA-74160", "R-HSA-9006936", "R-HSA-3858494", "R-HSA-212436", "R-HSA-4608870" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q9HCE7", "ensembl_id": "ENSG00000198742", "entrez_id": "57154", "chromosome_number": "7", "lastmodified": "2021-10-18T11:00:44.793178" }, "relationships": { "variant_set": { "meta": { "count": 1 }, "data": [ { "type": "SmallVariant", "id": "1529" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMURF1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMURF1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 1 }, "data": [ { "type": "GeneCombination", "id": "490" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SMURF1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SMURF1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SMURF1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 5 } }