Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/1112/genes/?format=api
{ "data": [ { "type": "Gene", "id": "NR0B1", "attributes": { "go_molecular_function": [ "['RNA binding', 'transcription factor binding', 'DNA hairpin binding', 'RNA polymerase II-specific DNA-binding transcription factor binding', 'protein domain specific binding', 'nuclear receptor binding', 'protein binding', 'transcription corepressor activity', 'protein homodimerization activity']" ], "pathway_id": [ "kegg_path:hsa04927", "kegg_path:hsa04927" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P51843", "ensembl_id": "None", "entrez_id": "ENSG00000169297", "chromosome_number": "X", "lastmodified": "2022-08-04T14:14:58.385768" }, "relationships": { "variant_set": { "meta": { "count": 6 }, "data": [ { "type": "SmallVariant", "id": "2397" }, { "type": "SmallVariant", "id": "2516" }, { "type": "SmallVariant", "id": "2852" }, { "type": "SmallVariant", "id": "2981" }, { "type": "SmallVariant", "id": "3263" }, { "type": "SmallVariant", "id": "3304" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR0B1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR0B1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 6 }, "data": [ { "type": "GeneCombination", "id": "816" }, { "type": "GeneCombination", "id": "854" }, { "type": "GeneCombination", "id": "950" }, { "type": "GeneCombination", "id": "995" }, { "type": "GeneCombination", "id": "1097" }, { "type": "GeneCombination", "id": "1112" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/NR0B1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/NR0B1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/NR0B1/?format=api" } }, { "type": "Gene", "id": "SOX8", "attributes": { "go_molecular_function": [ "['DNA binding', 'DNA-binding transcription factor binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'sequence-specific double-stranded DNA binding', 'DNA-binding transcription factor activity, RNA polymerase II-specific']" ], "pathway_id": [], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "P57073", "ensembl_id": "None", "entrez_id": "ENSG00000005513", "chromosome_number": "16", "lastmodified": "2023-05-16T12:02:33.537424" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3174" }, { "type": "SmallVariant", "id": "3306" }, { "type": "SmallVariant", "id": "3713" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX8/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX8/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "1061" }, { "type": "GeneCombination", "id": "1112" }, { "type": "GeneCombination", "id": "1256" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SOX8/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SOX8/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SOX8/?format=api" } }, { "type": "Gene", "id": "SRA1", "attributes": { "go_molecular_function": [ "['steroid receptor RNA activator RNA binding', 'nuclear receptor coactivator activity', 'transcription coactivator activity', 'DNA binding', 'protein binding']" ], "pathway_id": [], "essential_gene": null, "status": "CU", "uniprot_acc": "Q9HD15", "ensembl_id": "None", "entrez_id": "ENSG00000213523", "chromosome_number": "5", "lastmodified": "2021-10-18T11:00:44.268998" }, "relationships": { "variant_set": { "meta": { "count": 7 }, "data": [ { "type": "SmallVariant", "id": "35" }, { "type": "SmallVariant", "id": "1211" }, { "type": "SmallVariant", "id": "1424" }, { "type": "SmallVariant", "id": "2777" }, { "type": "SmallVariant", "id": "3299" }, { "type": "SmallVariant", "id": "3301" }, { "type": "SmallVariant", "id": "3305" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRA1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 8 }, "data": [ { "type": "GeneCombination", "id": "14" }, { "type": "GeneCombination", "id": "386" }, { "type": "GeneCombination", "id": "448" }, { "type": "GeneCombination", "id": "928" }, { "type": "GeneCombination", "id": "1109" }, { "type": "GeneCombination", "id": "1110" }, { "type": "GeneCombination", "id": "1112" }, { "type": "GeneCombination", "id": "1124" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SRA1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SRA1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 3 } }