Gene List
This API endpoint handles listing (/genes) and retrieval (/genes/<ID>/) of genes that are contained in the database due to their association to
genetic variants that are involved in at least one oligogenic combination in OLIDA.
GET /api/genecombinations/879/genes/?format=api
{ "data": [ { "type": "Gene", "id": "ATP7B", "attributes": { "go_molecular_function": [ "['P-type monovalent copper transporter activity', 'copper ion transmembrane transporter activity', 'P-type divalent copper transporter activity', 'ATP binding', 'copper ion binding', 'protein binding']" ], "pathway_id": [ "kegg_path:hsa01524", "kegg_path:hsa04978", "kegg_path:hsa01524", "kegg_path:hsa04978", "kegg_path:hsa01524", "kegg_path:hsa04978", "R-HSA-382551", "R-HSA-936837", "R-HSA-983712" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "P35670", "ensembl_id": "None", "entrez_id": "ENSG00000123191", "chromosome_number": "13", "lastmodified": "2023-05-16T12:02:32.481279" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "2636" }, { "type": "SmallVariant", "id": "3119" }, { "type": "SmallVariant", "id": "3285" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7B/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATP7B/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1044" }, { "type": "GeneCombination", "id": "1106" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7B/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/ATP7B/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/ATP7B/?format=api" } }, { "type": "Gene", "id": "FOXP1", "attributes": { "go_molecular_function": [ "['core promoter sequence-specific DNA binding', 'RNA polymerase II cis-regulatory region sequence-specific DNA binding', 'DNA-binding transcription repressor activity, RNA polymerase II-specific', 'protein self-association', 'DNA-binding transcription factor activity, RNA polymerase II-specific', 'sequence-specific double-stranded DNA binding', 'protein binding', 'metal ion binding', 'identical protein binding', 'androgen receptor binding']" ], "pathway_id": [ "kegg_path:hsa05206", "kegg_path:hsa05206" ], "essential_gene": "Essential", "status": "CU", "uniprot_acc": "A0A0B4J2F3", "ensembl_id": "None", "entrez_id": "ENSG00000114861", "chromosome_number": "3", "lastmodified": "2023-05-16T12:02:32.502054" }, "relationships": { "variant_set": { "meta": { "count": 3 }, "data": [ { "type": "SmallVariant", "id": "3208" }, { "type": "SmallVariant", "id": "2639" }, { "type": "SmallVariant", "id": "3266" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FOXP1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FOXP1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 3 }, "data": [ { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1072" }, { "type": "GeneCombination", "id": "1098" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/FOXP1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/FOXP1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/FOXP1/?format=api" } }, { "type": "Gene", "id": "SETX", "attributes": { "go_molecular_function": [ "['DNA binding', 'hydrolase activity', 'protein binding', 'RNA binding', 'DNA helicase activity', 'transcription termination site sequence-specific DNA binding', 'identical protein binding', 'ATP binding']" ], "pathway_id": [ "kegg_path:hsa05014" ], "essential_gene": null, "status": "CU", "uniprot_acc": "Q7Z333", "ensembl_id": "None", "entrez_id": "ENSG00000107290", "chromosome_number": "9", "lastmodified": "2021-10-18T11:00:44.749548" }, "relationships": { "variant_set": { "meta": { "count": 23 }, "data": [ { "type": "SmallVariant", "id": "528" }, { "type": "SmallVariant", "id": "538" }, { "type": "SmallVariant", "id": "544" }, { "type": "SmallVariant", "id": "546" }, { "type": "SmallVariant", "id": "547" }, { "type": "SmallVariant", "id": "921" }, { "type": "SmallVariant", "id": "929" }, { "type": "SmallVariant", "id": "1381" }, { "type": "SmallVariant", "id": "1425" }, { "type": "SmallVariant", "id": "1431" }, { "type": "SmallVariant", "id": "1439" }, { "type": "SmallVariant", "id": "1726" }, { "type": "SmallVariant", "id": "1727" }, { "type": "SmallVariant", "id": "2041" }, { "type": "SmallVariant", "id": "2044" }, { "type": "SmallVariant", "id": "2054" }, { "type": "SmallVariant", "id": "2099" }, { "type": "SmallVariant", "id": "2100" }, { "type": "SmallVariant", "id": "2637" }, { "type": "SmallVariant", "id": "3435" }, { "type": "SmallVariant", "id": "3443" }, { "type": "SmallVariant", "id": "3608" }, { "type": "SmallVariant", "id": "3609" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 18 }, "data": [ { "type": "GeneCombination", "id": "174" }, { "type": "GeneCombination", "id": "177" }, { "type": "GeneCombination", "id": "180" }, { "type": "GeneCombination", "id": "181" }, { "type": "GeneCombination", "id": "185" }, { "type": "GeneCombination", "id": "186" }, { "type": "GeneCombination", "id": "187" }, { "type": "GeneCombination", "id": "290" }, { "type": "GeneCombination", "id": "452" }, { "type": "GeneCombination", "id": "454" }, { "type": "GeneCombination", "id": "456" }, { "type": "GeneCombination", "id": "458" }, { "type": "GeneCombination", "id": "568" }, { "type": "GeneCombination", "id": "703" }, { "type": "GeneCombination", "id": "727" }, { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1156" }, { "type": "GeneCombination", "id": "1213" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SETX/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SETX/?format=api" } }, { "type": "Gene", "id": "SORL1", "attributes": { "go_molecular_function": [ "['amyloid-beta binding', 'small GTPase binding', 'neuropeptide binding', 'transmembrane signaling receptor activity', 'protein binding', 'low-density lipoprotein particle binding', 'low-density lipoprotein particle receptor activity']" ], "pathway_id": [ "R-HSA-392499", "R-HSA-977225" ], "essential_gene": "Non-essential", "status": "CU", "uniprot_acc": "Q92673", "ensembl_id": "None", "entrez_id": "ENSG00000137642", "chromosome_number": "11", "lastmodified": "2023-05-16T12:02:32.497689" }, "relationships": { "variant_set": { "meta": { "count": 2 }, "data": [ { "type": "SmallVariant", "id": "2638" }, { "type": "SmallVariant", "id": "3097" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SORL1/relationships/variant_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SORL1/variants/?format=api" } }, "genecombination_set": { "meta": { "count": 2 }, "data": [ { "type": "GeneCombination", "id": "879" }, { "type": "GeneCombination", "id": "1038" } ], "links": { "self": "https://olida.ibsquare.be/api/genes/SORL1/relationships/genecombination_set?format=api", "related": "https://olida.ibsquare.be/api/genes/SORL1/genecombinations/?format=api" } } }, "links": { "self": "https://olida.ibsquare.be/api/genes/SORL1/?format=api" } } ], "meta": { "database_name": "OLIgogenic diseases DAtabase (OLIDA)", "resource_url": "olida.ibsquare.be", "api_release_year": "2021", "api_developer": [ [ "Arnau Dillen", "arnau.dillen@ulb.ac.be" ], [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_version": "0.3", "api_maintainers": [ [ "Charlotte Nachtegael", "charlotte.nachtegael@ulb.be" ] ], "api_documentation": [ "olida.ibsquare.be/api/swagger", "olida.ibsquare.be/api/redoc" ], "copyright": "Copyright (c) 2025 · OLIDA All Rights Reserved.", "license": "CC Attribution-NonCommercial 4.0 International License", "ontologies": { "ORDO": "http://bioportal.bioontology.org/ontologies/ORDO", "GENO": "http://purl.obolibrary.org/obo/geno.owl", "MI": "http://purl.obolibrary.org/obo/mi.owl", "NCIT": "http://purl.obolibrary.org/obo/ncit.owl", "OGI": "http://purl.obolibrary.org/obo/ogi.owl", "OGG": "http://purl.obolibrary.org/obo/ogg.owl" }, "relevant_publications_doi": [ "10.1093/nar/gkv1068", "10.1093/database/baac023" ], "size": 4 } }